Amlopin – Medicine used in hypertension treatment

Amlopin contains an active substance called Amlodipine. It belongs to the group of medicines called calcium channel blockers. This medicine works by expanding the blood vessels thereby lowering blood pressure and improving blood flow to your heart. Because of these effects, it is used to treat hypertension (high blood pressure) and Prinzmetal’s angina.


It should be avoided in patients allergic to the active substance Amlodipine or other similar medicines such as:

  • nicardipine,
  • nimodipine,
  • nifedipine (Nifelat) and others. If you are experiencing symptoms of an allergy such as:
    • rash,
    • itching,
    • redness,
    • swelling,
    • difficulty breathing, contact your doctor immediately.

This drug should be avoided in patients with aortic stenosis (narrowing of the aortic valve in the heart) or damaged heart valves as well as in patients with low blood pressure (hypotension).

Amlopin may be used only with extra precautions in patients with liver disorders. It is necessary to reduce the dose in patients with liver disorders as well as in the elderly patients (above the age of 65).

It should not be used in combination with alcoholic beverages and grapefruit juice. Both, alcohol and grapefruit juice may increase the level of Amlopin in your blood, therefore increasing the risk of side effects.

Use during pregnancy and breastfeeding

Amlopin is classified in group C (FDA: Group C), which means that animal studies have shown adverse effects on fetus, but there are no studies on humans. This medicament should be used during pregnancy only if the benefit to the mother outweighs the risk to the child.

There are no data whether if Amlopin passes into breast milk. Avoid breastfeeding while using Amlopin. If, however, you are using this drug, as a substitute for breast milk, you can give your baby formula milk.


How to use

It is usual to start treatment on a low dose (usually 5 mg) and then gradually increase the dose until the desired effect is achieved. After an initial dose of 5 mg, the dose is usually increased up to 10 mg per day.

Amlopin can be taken regardless of food, because food does not change efficacy of Amlopin.

Avoid alcoholic beverages and grapefruit while using this medicine. Alcohol and grapefruit juice may increase the level of Amlopin in your blood and cause side effects.

In elderly and patients aged 8-17 years, the recommended dose is 2.5 mg once a day. In patients with liver disorders, the dose should be reduced.


Symptoms of an overdose include:

  1. fatigue,
  2. dizziness,
  3. headache.

Immediately tell your doctor if you are experiencing any of the above symptoms.

Use with other medicines (Interactions)

Amlopin should be avoided in combination with the following medicines:

  • rosuvastatin,
  • simvastatin,
  • pravastatin,
  • lovastatin,
  • atorvastatin, and other statins used in the treatment of high cholesterol. Red yeast rice, also contains a substance similar to lovastatin, so the red rice should not be used in combination with Amlopin.
  • Ketoconazole, itraconazole, fluconazole, clotrimazole and other medicines used in the treatment of fungal infections.
  • Nelfinavir, saquinavir, ritonavir, efavirenz, lopinavir and other medicines used for the HIV treatment.
  • Medicines used to treat bacterial infections such as:
    • erythromycin,
    • clarithromycin,
    • telithromycin,
    • azithromycin,
    • rifampicin,
    • isoniazid, and others.
  • Verapamil, diltiazem, nifedipine, nicardipine, nimodipine and other calcium channel blockers.
  • St. John’s Wort.

Tell your doctor about all medications and herbal medicines you are taking.

Amlopin side effects

Amlopin may cause the following side effects:

  1. redness,
  2. headache,
  3. dizziness,
  4. drowsiness,
  5. palpitations (feeling that your heart is beating too fast),
  6. nausea,
  7. vomiting,
  8. fatigue,
  9. stomach pain,
  10. low blood pressure (hypotension),
  11. muscle pain,
  12. joint pain,
  13. hair loss (alopecia),
  14. gynecomastia (breast enlargement in men),
  15. trouble urinating,
  16. mood disorders (depression, anxiety),
  17. blurred vision,
  18. photosensitivity (increased sensitivity to sunlight),
  19. chest pain,
  20. heart attack,
  21. allergy and others.

Immediately tell your doctor if you are experiencing any side effects.


Comments are closed.