Cefapan – Use | Dose | Side effects

Cefapan is a medicine that contains an active ingredient called cefixime. It belongs to a group of medicines called cephalosporin antibiotics (third generation cephalosporins). It works by killing a wide range of Gram positive and Gram negative bacteria, therefore it is used to treat following infections:

  • Respiratory tract infections, such as: bacterial brocnhitis, pneumonia and pharyngitis.
  • Middle ear infections (Otitis media).
  • Urinary tract infections (cystitis, pyelonephritis)

It is one of the most effective antibiotics, but as all other antibiotics, it should be used with extra precautions in order to avoid antibiotic resistance. It is available by prescription only.


Cefapan should be avoided in following conditions:

  • In patients allergic to active substance (cefixime) or any other similar medicines, such as:
    • penicillin,
    • cefalexin,
    • cefaclor,
    • cefepim,
    • cefpodoxime,
    • cefuroxime,
    • ceftazidime and others. If you are experiencing symptoms of an allergy, such as:
      • itchy skin,
      • hives,
      • swelling of the face,
      • swelling of the lips or difficulty breathing call your doctor immediately.
  • Patients who have had colitis.
  • In patients with renal impairment.

Cefapan may lead to Stevens-Johnson syndrome (serious adverse reaction of the skin – painful red rash that spreads and blisters). Fortunately, this risk of Stevens-Johnson syndrome is very rare. If you are experiencing any skin changes, call your doctor immediately.

This medicine, as all other cephalosporin antibiotics, may lead to acute renail failure. If you are experiencing symptoms of renal failure, such as:

  • painful urination,
  • difficult urination,
  • dark-colored urine, call your doctor immediately.

This medicine should be avoided in children under the age of 6 months, unless recommended by doctor. In children above the age of 6 months, Cefapan syrup may be used.

Use of Cefapan during pregnancy and breastfeeding

Cefapan can be used during pregnancy only if the benefit to the mother outweighs risk to the child. Animal studies have shown that Cefapan is not harmful, but there are no human studies to support this.


Cefapan passes into breast milk, therefore breastfeeding should be avoided while using this medicine.

How to use

Recommended dosage:

Age and body weight


Patients above the age of 10 (body weight more than 50 kg) 200 mg twice a day or 400 mg once a day
Children aged 5-10 years 10 ml of syrup per day
Children aged 1-4 years 5 ml of syrup per day


Children aged 6 motnhs-1 year 3,75 ml of syrup per day



Treatment usually lasts for 7-14 days, depending on severity of infections. You should take this medicine until you finish prescription, even if you feel beter. If you stop taking this medicine early, it probably won’t kill all bacteria.

You should take this medicine 1 hour before or 2 hours after a meal.

Use of Cefapan with other medicines (Interactions)

Cefapan should be avoided in combination with following medicines:

  • Medicines used to treat thrombosis (so-called blood thinners), such as:
    • warfarin,
    • acenocoumarol and others. Concomitant use of Cefapan with these medicines, increases the risk of bleeding.

Tell your doctor about all medicines or hearbal products you are using.

Side effects

Cefapan may cause following side effects:

  1. nausea,
  2. vomiting,
  3. abdominal pain,
  4. diarrhea,
  5. flatulence,
  6. pseudomembranous colitis (an inflammatory disease of the colon),
  7. headaches,
  8. dizziness,
  9. kidney damage (decrase in the amount of urine, painful urination, difficult urination),
  10. liver damage,
  11. jaundice – yellow eyes and skin,
  12. Stevens-Johnson syndrome,
  13. anorexia,
  14. loss of appetite,
  15. low white blood cell count (agranulocytosis),
  16. anemia,
  17. mucous membrane inflammation,
  18. low blood platelet count (thrombocytopenia),
  19. depression,
  20. confusion,
  21. allergy and others.

Call your doctor if you are experiencing any of abovementioned side effects.


Comments are closed.