Cephradine – How to use | Dosage | Side effects

Cephradine is medicine that belongs to the group of medicines called cephalosporins. Cephalosporins are antibiotics that kill bacteria.

This medicine is used in the treatment of the following infections:

  • Urinary tract infections
  • Respiratory tract infections
  • Skin and soft tissue infections
  • Middle ear infections


It should be avoided in patients who are allergic to Cephradine or other similar medicines, including penicillin. If you are experiencing symptoms of an allergy (hives, itching, swelling, difficulty breathing) contact your physician immediately.

Cephradine should be avoided in patients who have or have ever had colitis (intestinal infection) or in patients with renal failure.

It may affect the results of certain lab tests.

Use of Cephradine during pregnancy and breastfeeding

Cephradine should be used during pregnancy only if the benefit to the mother outweighs the risk to the child.

Avoid breastfeeding while using this medicine. Instead of breastfeeding your baby, you can give your baby formula milk.


How to use

The usual dose is 250 mg every 6 hours (4 times a day) or 500 mg every 12 hours (twice a day). The dose may be increased according to the severity of infection.

It can be taken regardless of food, because food does not change efficacy of Cephradine tablets.

In children, the dose should be calculated on the basis of body weight.

The maximum daily dose is 4000 mg.

Use with other medicines (Interactions)

Cephradine should be avoided in combination with the following medicines:

  • Probenecid, medicine used in the treatment of gout.
  • Furosemide, medicine used to treat high blood pressure (also known as water pill).
  • Warfarin (Farin), a blood-thinning medicine
  • If you are using other antibiotics such as:
    • gentamycin,
    • amikacin,
    • streptomycin,
    • vancomycin and others.

Tell your doctor about all medications and herbal medicines you are taking.

Side effects

Cephradine may cause the following side effects:

  1. nausea,
  2. vomiting,
  3. diarrhea (sometimes accompanied by blood in the stool),
  4. liver damage accompanied with jaundice – yellowing of the skin and eyes,
  5. dark color of the urine which is also a sign of liver damage,
  6. confusion,
  7. headache,
  8. dizziness,
  9. decrease in the number of white blood cells (leucopenia),
  10. joint pain,
  11. flu-like symptoms (fever, sore throat),
  12. allergy and others.

Tell your doctor if you are experiencing any side effects.


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