Cifran – How to use, dosage and side effects

Cifran is a medicine that contains an active substance called ciprofloxacin. It belongs to a group of medicines called fluoroquinolone antibiotics. It has bactericidal effect (kills the bacteria that are causing an infection). Because of such effect it is used in the treatment of infections caused by bacteria sensitive to this drug. It is used in the treatment of the following infections:

  • Respiratory tract infections
  • Urinary tract infections
  • Genital infections in both men and women
  • Skin and soft tissue infections
  • Bone in joint infections
  • Gastrointestinal tract infection
  • Infections due to low leukocyte count (agranulocytosis)

Cifran can also be used in the treatment of anthrax.


Cifran should be avoided in the following conditions:

  • In patients allergic to ciprofloxacin or other similar drugs, such as:
    • oflksacin (Visiren),
    • norfloxacin,
    • levofloxacin, and others. If you are experiencing symptoms of an allergy, such as:
      • itchy skin,
      • swelling of the face,
      • swelling of the tognue or difficulty breathing contact your doctor immediately.
  • Patients with myasthenia gravis (autoimmune neuromuscular disease).
  • In patients suffering from epilepsy.
  • Heart disease
  • In patients with kidney or liver diseases.

It can cause swelling of tendons, especially in women above the age of 60. If you are experiencing swelling of the tendons (or swelling of the muscles), discontinue use and contact your doctor immediately. Tendons connect muscle to bone.

Resting the swollen and painful tendons is necessary, because physical activity increase the chance of tendon rupture. Bear in mind that swelling of the tendons can occur several months after you have discontinued the use of Cifran.

This medicine can, like all other antibiotics, cause diarrhea. Inform your doctor if you are experiencing frequent, severe, and bloody diarrhea as this may be a sign that another infection occurred in your bowels, and such infections can be dangerous.

This medicine may cause liver damage, which is manifested by the following symptoms: jaundice (yellowing of the skin and eyes), dark urine color, nausea, vomiting, loss of appetite, pain in the right upper abdomen and others. If you are experiencing any of these symptoms, discontinue use and contact your doctor immediately.


Although Cifran is used to treat infections that occur due to the low white blood cells count (agranulocytosis), it also can by itself to decrease the number of white blood cells. Decrease in the number of white blood cells, lower the immune system, and increases your susceptibility to infections. If you are experiencing flu-like symptoms, such as: cough, sore throat, fever, contact your doctor immediately.

This medication can cause photosensitivity (abnormally high sensitivity to sunlight). Avoid increased exposure to sunlight and cover up the body as much as possible when you are out in the sunshine.

Cifran can worsen the symptoms of patients of psychiatric disorders. It can cause suicidal ideation. If you are experiencing any suicidal thoughts, contact your doctor immediately.

Use during pregnancy and breastfeeding

CIFRAN should be avoided during pregnancy unless the benefit to the mother outweighs the risk to the child. Consult your doctor about the drug safety during the pregnancy.

Avoid breastfeeding while using this medicine. This medication passes into breast milk and may harm your baby.

How to use

Dosage in adults:

Condition (Indication) Dose


Acute uncomplicated cystitis in women 250 mg or 500 mg twice a day (every 12 hours) for three days.
Complicated cystitis and complicated pyelonephritis 500 mg twice a day (every 12 hours), for one week.
Chronic prostatitis 500 mg twice a day (every 12 hours) for 4 weeks (28 days).
Respiratory tract infections 500 mg (for severe infections dose can be increased to 750 mg) twice a day during 7 to 14 days.
Gonorrhea 500 mg once a day, for just one day.


Antibiotic prophylaxis in surgery 750 mg, an hour before the surgery.
Gastrointestinal tract infections 500 mg twice a day (every 12 hours) for 3-7 days.
Bone and joint infections 500 or 750 mg twice a day (every 12 hours), up to 3 months.


Use of Cifran in children is not recommended! If necessary to use this medication in children, then the dose should be calculated based on the child’s body weight. The usual dose is 20 mg / kg of body weight.

Take your tablet whole, with a glass of water. Do not crush or chew the tablet as this may affect its activity. It should be taken after a meal. Avoid dairy products while using this medicine, because milk and dairy products may decrease the level of Cifran in the blood due to the high calcium content.

Use with other medicines (Interactions)

Cifran should be avoided in combination with the following drugs:

  • Tizanidine (muscle relaxants), a drug used in the treatment of muscle stiffness. Do not use Cifran and tizanidine concomitant because of the risk of serious side effects!
  • Warfarin, a drug used in the treatment of blood clotting disorders (so-called blood thinner). Concomitant use of Cifran with this drug increases the risk of bleeding.
  • Sildenafil (Viagra), a drug used in the treatment of erectile dysfunction. This medicine increases the level of sildenafil in the blood, increasing the risk of side effects.
  • Pentoxifylline (Trental, Damaton), a drug used to improve peripheral circulation. Cifran increases the level of this drug in the blood and increases the risk of side effects.
  • Phenytoin, a drug used in the treatment of epilepsy.
  • Methotrexate, a drug used in the treatment of cancer.
  • Cyclosporin, a drug used in the treatment of autoimmune diseases.
  • Probenecid, a drug used for gout treatment.
  • Drugs used in the treatment of diabetes.
  • Drugs used in the treatment of cardiac arrhythmias (antiarrhythmics).
  • Drugs used in the treatment of depression and other mental diseases.
  • Omeprazole (Omeprol), a drug used for eradication of Helicobacter pylori and to treat gastroesophageal reflux disease. This medicine decreases the level of Cifran in the blood, thus reducing the efficacy of this drug.
  • Calcium, magnesium or iron preparations (including effervescent tablets). These drugs reduce the efficacy of Cifran.
  • Antacids, drugs that neutralize stomach acid. These drugs reduce the effect of Cifran.

Tell your doctor about all medications and herbal products you are taking.

Side effects

Cifran may cause the following side effects:

  1. nausea,
  2. vomiting,
  3. abdominal pain,
  4. diarrhea (can be accompanied by blood in the stool),
  5. indigestion,
  6. flatulence,
  7. impaired taste,
  8. loss of appetite,
  9. headache,
  10. dizziness,
  11. decrease in the number of white blood cells (agranulocytosis),
  12. flu-like symptoms (cough, fever, sore throat),
  13. liver damage (jaundice, loss of appetite, itching, nausea, vomiting, pain in the right upper abdomen, dark urine color),
  14. suicidal ideation (suicidal thoughts),
  15. mood swings,
  16. nightmares,
  17. hallucinations,
  18. photosensitivity (increased sensitivity to the sunlight),
  19. rapid heartbeat,
  20. Stevens-Johnson syndrome (a severe skin disorders that is manifested by blisters on the skin that can spread),
  21. muscle pain,
  22. joint pain,
  23. tendon rupture,
  24. excessive sweating,
  25. allergy and others.

Tell your doctor if you are experiencing any side effects.


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