Information about Clexane, how to use, dosage and side effects

Clexane is a medicine that contains an active substance known as enoxaparin. It belongs to the group of anticoagulants (drugs used to prevent the blood clots from forming). It is used in all conditions when it is necessary to prevent the blood clots from forming. It is used in the following conditions:

  • Treatment of deep vein thrombosis
  • Treatment of unstable angina pectoris
  • Treatment of some types of heart attack
  • Venous thromboembolism


Clexane should be avoided in people allergic to enoxaparin or other similar drugs.

It should be avoided in patients with active bleeding or are at risk of bleeding, because such patients are at increased risk from bleeding.

It should be avoided in patients with a low platelet count (thrombocytopenia).

Clexane should be used only with extra precautions in patients with high blood pressure.

It should be used only with extra precautions in the following conditions:

  • In patients with liver or kidney damage
  • Patients with von Wilebrand’s disease (a genetic disease manifested by prolonged and excessive bleeding)
  • In patients who have recently undergone surgery
  • In patients with gastric or duodenal ulcer
  • Patients who have suffered a stroke
  • In patients who are taking acetylsalicylic acid (also known as Aspirin, Andol, Cardiopirin) and other drugs that affect platelet function
  • In patients with diabetic retinopathy

This medicine can be used by trained health staff in health facilities, but the medical staff can teach you to use Clexane injections at home. Patients who are using this drug themselves must know that this drug should be used under the skin. Clexane injection should be never injected into muscle! If you notice that the solution has changed color or vial is damaged, do not use an injection.


Use during pregnancy and breastfeeding

Clexane can be used during pregnancy only if the benefit to the mother outweighs the risk to the child. Talk with your doctor about the benefits and risks of using Clexane drug during pregnancy.

Avoid breastfeeding while using this drug.

How to use

Dosage forms include: (Clexane 2000 international units-IU), Clexane 4000 IU, Clexane 6000 IU, Clexane 8000 IU and Clexane 10 000 IU. Clexane should be injected under the skin (cannot be injected into muscle). Do not use Clexane injections by yourself if health staff didnot teach you how you should apply Clexane.


Condition Dosage
Prophylaxis of venous thromboembolism


2000 IU to 4000 IU once daily


The treatment of deep vein thrombosis


100 IU per kg of body weight twice a day or 150 IU per kg of body weight once a day. The dose should be calculated based on body weight (patient’s body weight should be multiplied by 100 or 150). Example: For a patient whose body weight is 80 kg, a dose should be calculated as follows:

100 IU x 80 = 8000 IU twice a day or

150 x 8 = 12,000 IU once a day

The treatment of unstable angina pectoris


100 IU per kg of body weight, twice a day


Treatment of heart attack


100 IU per kg of body weight, twice a day


Prevention of blood clot formation in  thehemodialysis


50 IU per kg of body weight, twice a day


Your doctor will determine which dose is suitable for you.

It is necessary to reduce the dose in patients with renal disorders.

Use with other medicines (Interactions)

Clexane should be used with extra precautions in combination with the following drugs:

Tell your doctor about all medications and herbal products you are taking.

Side effects

Clexane may cause the following side effects:

  1. low platelet count (thrombocytopenia),
  2. bleeding,
  3. pain at the site of injection,
  4. irritation at the site of injection,
  5. dizziness,
  6. confusion,
  7. fatigue,
  8. diarrhea,
  9. allergy and others.

Tell your doctor if you are experiencing any side effects.


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