Coaxil – Depression medication

Coaxil is a medicine that contains an active substance called tianeptine. It belongs to a group of depression medications and it is used to treat major depression.


Coaxil should be avoided in the following conditions:

  • In patients allergic to the active substance tianeptine or other similar medicines. If you are experiencing symptoms of an allergy, such as:
    • rash,
    • itching,
    • swelling of the face,
    • swelling of the tongue,
    • difficulty breathing, contact your doctor.
  • Patients under the age of 18.
  • In patients taking other antidepressants, known as MAO inhibitors, scuh as:
    • moclobemide,
    • selegiline,
    • isocarboxazid, and others. If you are using this medicines, you should discontinue using them at least two weeks before you start using this medicine.

If you are planning an surgery, tell your surgeon that you are taking this medicine.

This medicine can cause suicidal thoughts and behaviors, therefore patients and their relatives must be informed to contact doctor if they notice any changes in patients behavior. Such thoughts more often occur in young adults.

Use of Coaxil during pregnancy and breastfeeding

It should not be used during pregnancy, although there is not enough clinical data on the use of this medicine during pregnancy.

Coaxil passes into breast milk, therefore breastfeeding should be avoided while using this medicine.

How to use

The usual dose is 12.5 mg (one tablet of Coaxil) three times a day. In patients above the age of 65, the dose can be reduced to 12.5 mg twice a day (in the morning and evening).


The tablet should be taken before meals. Do not chew the tablet, but swallow it whole with a glass of water.

Use with other medicines (Interactions)

It should be avoided in combination with the following medicines:

  • MAO inhibitors, medicines that are also used to treat depression. The concomitant use of these medicines with Coaxil, can lead to serious cardiovascular (heart) problems and even to possible fatal outcome! If you stop taking any of the MAO inhibitors, tou should wait at least two weeks before you start to take Coaxil.
  • Mianserin, a medicine that is also used to treat depression.

Coaxil should never be used in combination with alcoholic beverages, due to an increased risk of side effects.

Tell your doctor about all medications and herbal products you are taking.

Side effects

Coax may cause the following side effects:

  1. nausea,
  2. vomiting,
  3. constipation,
  4. abdominal pain,
  5. loss of appetite,
  6. headache,
  7. dizziness,
  8. loss of consciousness,
  9. insomnia,
  10. nightmares,
  11. involuntary movements,
  12. tremors,
  13. rapid heartbeat (tachycardia),
  14. chest pain,
  15. confusion,
  16. hallucinations,
  17. muscle pain,
  18. liver damage,
  19. suicidal thoughts,
  20. addiction,
  21. allergy and others.

Tell your doctor if you are experiencing any side effects.


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