Detrusitol – Use | Dose | Side Effects

Detrusitol is a medicine that contains an active substance called tolterodine. It belongs to a group of medicines called urinary antispasmodics. It works by reducing spasms of bladder muscles. It is used to treat following conditions:

  • Urinary incontinence (loss of bladder control-unintentional passing of urine)
  • Overactive bladder (urinary frequency, urgency)

Urinary incontinence is a common and embarrassing problem, and need to be treat.


Detrusitol should be avoided in the following conditions:

  • Patients with myasthenia gravis (autoimmune disorder characterized by muscle weakness).
  • In patients with ulcerative colitis (disorder characterized by of ulcers and inflammation in the colon).
  • In patients with toxic megacolon (acute, toxic inflammatory bowel disease characterized by dilatation of the bowels).
  • In patients who are allergic to the active substance tolterodine or other similar medicines.
  • Patients who have increased eye pressure (glaucoma).
  • In patients with urinary retention (inability to urinate).
  • In patients with renal impairment.
  • In patients who have heart diseases.

This medicine should be used only with extra precautions in the following conditions:

  • In patients who have gastrointestinal diseases.
  • In patients with hepatic impairment.
  • In patients with hiatus hernia (a protrusion of a portion of the stomach into the thorax).
  • In patients with hypokalemia (low potassium levels), hypocalcemia (low calcium levels in the blood), hypomagnesemia (low level of magnesium in the blood). This medicine can cause arrhythmias (irregular heartbeat) in such patients.

This medicine may cause dizziness, therefore if you are experiencing dizziness, you should avoid driving a motor vehicle or operating machinery.

Use of Detrusitol during pregnancy and breastfeeding

This medicine should not be used during pregnancy, due to insufficient data on its use during pregnancy.

It is not known whether this medicine passes into breast milk, therefore breastfeeding should be avoided in patients taking this medicine.


How to use

The usual dose is 2 mg twice a day (in the morning and in the evening). If you are experiencing side effects (dry mouth, dizziness), the dose can be reduced to 1 mg twice a day.

The usual duration of treatment is 3 months. After that, your doctor should decide whether you can keep taking this medicine.

This medicine can be taken with or without food, because food does not affect the effectiveness of this medicine.

Use with other medicines (Interactions)

Detrusitol should be avoided in combination with the following medicines:

  • Antibiotics, medicines used in the treatment of bacterial infections, such as:
  • Medicines used in the treatment of irregular heartbeat (antiarrhythmic medicines), such as:
  • Medicines used to treat Parkinson’s disease.
  • Medicines used to treat allergic conditions (antihistamines), such as:
    • diphenhydramine,
    • astemizole,
    • terfenadine, and others.
  • Tranquilizers from the group of benzodiazepines, such as:
  • Potassium supplements.
  • Medicines used in the treatment of fungal infections, such as:
  • Medicines used to treat AIDS (HIV).
  • Medicines used to treat nausea, such as:
    • metoclopramide (Reglan). Concomitant use of Detrusitol with this medicine may reduce effectiveness of metoclopramide.

Tell your doctor about all medications and herbal products you are taking.

Side effects

Detrusitol may cause the following side effects:

  1. nausea,
  2. vomiting,
  3. diarrhea,
  4. constipation,
  5. dyspepsia,
  6. acid reflux – similar to heartburn (also known as gastroesophageal reflux disease),
  7. painful urination (dysuria),
  8. urinary retention,
  9. rapid heartbeat (tachycardia),
  10. arrhythmia (irregular heartbeat),
  11. dry mouth,
  12. visual disturbances,
  13. headache,
  14. dizziness,
  15. hallucinations,
  16. allergy and others.

Tell your doctor if you are experiencing any side effects.


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