Fosinopril – How to use | Dosage | Side Effects

Fosinopril belongs to a group of medicines called ACE inhibitors (ACE – angiotensin converting enzyme). This medicine works by expanding the blood vessels, thus reduces blood pressure.

It is used for the treatment of high blood pressure (hypertension) and heart failure. This drug can also be used in combination with diuretics (water pills), except with potassium sparing diuretics such as:

  • triamterene,
  • amiloride,
  • eplerenone,
  • spironolactone.


Fosinopril should be avoided in patients with high potassium levels in the blood (hyperkalaemia). It may increase potassium levels in the blood. High levels of potassium in the blood leads to the appearance of the following symptoms:

  1. slow heart rate (bradycardia),
  2. weak pulse,
  3. irregular heartbeat (arrhythmia).

Because of this effect, Fosinopril should be avoided in combination with drugs that may increase the level of potassium in the blood, such as:

  • diclofenac (Diklofen),
  • ibuprofen (Nurofen),
  • ketoprofen,
  • flurbiprofen,
  • potassium supplements,
  • spironolactone,
  • eplerenone,
  • triamterene,
  • amiloride.

Fosinopril should be avoided even in patients who have damaged heart valve or aortic stenosis (abnormal narrowing of the aorta).

It should be avoided in patients who are allergic to Fosinopril or other similar drugs:

This medicine should be also avoided in patients who have or have had cardiogenic shock.


It should be avoided during pregnancy, because it may harm your unborn baby.

Fosinopril needs to be taken with extra precautions in patients with kidney failure, liver disorders, rheumatoid arthritis, systemic lupus erythematosus.

Fosinopril should be avoided in patients with low blood pressure (hypotension).

Use during pregnancy and breastfeeding

It should be avoided during pregnancy, because it may harm your unborn baby. According to the US Food and Drug Administration, Fosinopril belongs to group D (FDA: Group D). This means that studies have shown that this medicine is harmful to the fetus and should not be used during pregnancy.

Fosinopril passes into breast milk and may harm your baby. Avoid breastfeeding while using this drug. Instead of breast milk, you can give your baby formula milk.

How to use

The initial dose of Fosinopril is 10 mg once a day. The dose can be gradually increased until the desired effect is achieved. The dose ranges from 10 mg to 40 mg per day.

It should be used every day at the same time of the day.

Use of Fosinopril is not recommended in children.

In elderly patients, it is necessary to adjust the dose.

Fosinopril should be taken regardless of food. You can take it with food or without it.

Swallow the tablet whole with a one glass of water. Do not crush or chew the tablets because it can reduce their efficacy.

Tablets should be used for as long as recommended by doctor. High blood pressure can be very dangerous and cause heart attack or stroke, therefore it is necessary to maintain blood pressure within normal limits.

High blood pressure usually causes no symptoms, but it is necessary to take your medicine even though you feel good.

At the beginning of the treatment, the doctor will probably ask you to frequently check your blood pressure, in order to determine what dose is right for you.

In addition to taking Fosinopril tablets, it is also necessary to change lifestyle:

  • Exercise at least half an hour a day.
  • Avoid fatty and spicy foods. If you are overweight, you need to reduce your body weight.
  • Eat fish meat at least 3 times a week. Some studies have shown that the fish meat reduce the frequency of heart attacks by 50%.
  • Avoid stress.
  • Quit smoking.

Use with other medicines (Interactions)

Fosinopril should be avoided with the following medications:

  • Potassium supplements.
  • Non-steroidal anti-inflammatory drugs, such as:
    • diclofenac (Diklofen),
    • ibuprofen (Nurofen),
    • ketoprofen,
    • flurbiprofen, and others.
  • Diuretics (water pills) sparing diuretics, such as:
    • eplerenone,
    • triamterene,
    • spironolactone and amiloride.
  • Lithium, used for the treatment of depression. It may increase the effect of lithium.
  • Medications used for the neutralization of the stomach acid, so-called antacids, such as:
    • aluminum carbonate,
    • aluminum hydroxide,
    • magnesium carbonate, and others. Antacids can reduce the effect of Fosinopril.
  • Immunosuppressive agents, used for the treatment of autoimmune diseases, such as:
    • cyclosporin and cyclophosphamide.
  • Drugs used to treat diabetes, such as:
    • insulin,
    • aliskiren. Fosinopril may increase the effect of these medications and lead to hypoglycemia (low blood sugar).
  • Gold preparations used to treat rheumatism, such as: auranofin. Concomitant use of Fosinopril with these medications leads to the appearance of so-called nitroid reaction whose symptoms include:
    • low blood pressure (hypotension),
    • nausea,
    • vomiting.

Tell your doctor about all medications and herbal products you are taking.

Side effects

It can cause dry and persistent cough. This side effect occurs frequently and can be so persistent, that you will need to change the medicine.

Fosinopril may increase potassium levels in the blood, which is manifested by the following symptoms: weak pulse, slow heart rate, irregular heartbeat. If you are experiencing these symptoms, contact your doctor immediately.

It may cause the following side effects:

  1. headache,
  2. dizziness,
  3. low blood pressure (hypotension),
  4. flushing,
  5. nausea,
  6. vomiting,
  7. decreased appetite,
  8. weight loss,
  9. insomnia,
  10. joint pain,
  11. muscle pain,
  12. difficulty urinating,
  13. weakness,
  14. fatigue,
  15. flu-like symptoms (fever, sore throat),
  16. tingling (paraesthesia),
  17. orthostatic hypotension (a condition in which your blood pressure falls when you stand up quickly),
  18. dry mouth,
  19. allergy and others.

Tell your doctor if you are experiencing any side effects.


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