Information about Monurol, how to use, dosage and side effects

Monurol is a medicine that contains an active substance called fosfomycin. It belongs to a group of broad-spectrum antibiotics (it is active against both gram positive and gram negative bacteria). It works by blocking the action of an enzyme called enolpyruvyl transferase thereby blocking the synthesis of bacteria cell wall. This drug kills the bacteria (bactericidal effect). Due to its specific mechanism of action it can also be used in combination with other antibiotics.

It is used to treat urinary tract infections as well as for surgical prophylaxis.


It should be avoided in patients allergic to the active substance fosfomycin.

This drug should be avoided in patients with kidney damage.

Monurol, like all other antibiotics, can lead to disruption of intestinal flora and cause colitis (inflammation of the inner lining of the colon). Immediately contact your doctor if you are experiencing diarrhea, especially if diarrhea lasts longer or is accompanied by blood.

It should be avoided in patients under the age of 12.

Avoid alcoholic beverages while using this drug.


Use during pregnancy and breastfeeding

Monurol can be used during pregnancy only if the benefit to the mother outweighs the risk to the child. Animal studies have shown no adverse effect on the fetus.

Avoid breastfeeding while using this drug.

How to use

Monurol is available in the form of a powder sachet at a dose of 3 g. The usual dose is one sachet (3 grams) used only once (single-dose treatment).

Monurol powder should be dissolved in a glass of water. Drink this mixture in the evening, just before bedtime. Empty your bladder before you take this medicine. Since food reduces drug availability, you need to take this medicine at least 3 hours after you last ate.

For surgical prophylaxis, it is necessary to apply one dose (3 g) three hours before surgery and another dose of 3 g 24 hours after surgery.

Use with other medications (Interactions)

Monurol should be avoided in combination with the following medicines:

  • Metoclopramide, a drug used to treat nausea. This medicine decrease the level of Monurol in the blood, therefore decreases the effect of this medicine
  • Lithium, a medicine used in the treatment of depression. This drug may decrease the effect of this medicine.
  • Tetracyclines, drugs that are used to treat bacterial infections. Monurol can decrease the effect of these medicines.

Tell your doctor about all medications and herbal products you are taking.

Side effects

Monurol may cause the following side effects:

  1. nausea,
  2. vomiting,
  3. diarrhea (may be accompanied by blood),
  4. colitis (inflammation of the colon),
  5. stomach pain,
  6. stomach upset,
  7. loss of appetite,
  8. fatigue,
  9. headache,
  10. dizziness,
  11. rapid heartbeat (tachycardia),
  12. low blood pressure (hypotension),
  13. sore throat,
  14. vaginal itching,
  15. liver damage (dark urine, loss of appetite, jaundice-yellowing of the skin and eyes),
  16. blood in urine,
  17. difficulty urinating,
  18. back pain,
  19. allergy and others.

Tell your doctor if you are experiencing any side effects.


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