Pheniramine – Remove symptoms of allergic reactions

Pheniramine is a medicine from the group of H1 antihistamines. It works by blocking the action of histamine on H1 receptors. Histamine is a substance which is released in allergic reactions. By blocking the action of histamine, this medicine removes the symptoms of allergic reactions.

It is used for the symptomatic alleviation of allergic conditions:

  • Allergic rhinitis (hay fever)
  • Mild angioedema
  • Allergic conjunctivitis
  • Allergic dermatitis (urticaria, pruritus)

It also can be used to treat travel sickness (kinetosis).


This drug cannot be used or can be used, only with great caution in the following conditions:

  • Allergic to pheniramine or other similar medicines. Although it is used for the treatment of allergy, it is possible that it cause an allergic reaction. Symptoms of an allergy are:
    1. skin rash,
    2. swelling of the tongue,
    3. swelling of the face,
    4. swelling of the throat,
    5. difficulty breathing. An allergic reaction can cause anaphylactic shock, and it is necessary to contact a doctor if you notice any of these symptoms.
  • Hyperplasia (enlarged prostate).
  • If you are taking medications used for the treatment of depression (called MAO inhibitors) or you have taken them within the past 14 days, such as:
    • phenelzine,
    • moclobemide,
    • selegiline.
  • Glaucoma
  • If you have liver damage
  • Breathing problems (asthma, bronchitis, emphysema)
  • Thyroid gland disease
  • If you suffer from epilepsy
  • Heart problems

It cannot be used in children younger than 2 years.

Pheniramine syrup usually contains a certain amount of sugar, and should be used with caution in diabetics.

Use during pregnancy and breast feeding

It is not recommended use of this drug during pregnancy and breast feeding. It can be harmful to your baby. Pheniramine can be used in pregnancy only if the benefit to the mother outweighs the risk to the child.


It is not known whether pheniramine passes into breast milk. Avoid breastfeeding while using this remedy.

Pheniramine Use and Dose

Pheniramine is available in the form of tablets and syrups. Syrups are intended mainly for children.

This medicament must be used with food or after meal.

Dosage for children:

Age Dose
Children aged 2-3 years 7.5 mg (2.5 ml), 2-3 times a day
Children aged 3-12 years 15 mg (5 ml), 2-3 times a day
Children older than 12 years 15-30 mg (5ml-10ml), times a day

Initial dose for adults: 25 mg 2-3 times a day with a glass of water. The dose can be increased to 50 mg 2-3 times a day.

If you are taking pheniramine for travel sickness, take a tablet or syrup for half an hour before traveling.

Swallow the tablet whole with a glass of water. Do not break the tablet and do not chew.

Use with other medicines (Interactions)

Pheniramine cannot be used or can be used only with great caution with the following medications:

  • MAO inhibitors, used to treat depression, such as:
    • moclobemide,
    • selegiline,
    • phenelzine and others.
  • Anticholinergic medications such as:
    • atropine,
    • scopolamine,
    • tiotropium,
    • ipratropium,
    • chlorpheniramine,
    • dimenhydrinate,
    • diphenhydramine,
    • tropicamide and others.
  • Medications used in the treatment of anxiety and tranquilizers

It should not be used in combination with the aforementioned medications, because it can cause:

  1. severe headaches,
  2. dizziness,
  3. fainting and loss of consciousness.

Pheniramine should not be used in combination with alcoholic beverages because it increases the risk of side effects.

Side effects

Pheniramine may cause the following side effects:

  1. severe headache,
  2. dizziness,
  3. hallucinations,
  4. loss of consciousness,
  5. confusion,
  6. mood changes,
  7. impaired coordination,
  8. nausea,
  9. vomiting,
  10. liver damage manifested as jaundice (yellowing of the skin and eyes),
  11. painful urination,
  12. allergic reactions and others.

Allergy symptoms include:

  • skin rash,
  • swelling of the face,
  • difficulty breathing. An allergic reaction can cause anaphylactic shock which can be fatal. Immediately contact your doctor if you experience these symptoms.


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