Acetec

Acetec tablets - Dosage | Use | Interactions

Acetec tablets contain the active substance enalapril-maleate. It belongs to a family of drugs known as ACE inhibitors (ACE - angiotensin-converting enzyme). It belongs to one of the most widely used drugs due to its relatively good safety profile and efficiency.

Acetec dosage forms include: 2.5 mg, 5 mg, 10 mg and 20 mg tablets. The maximum plasma concentration is reached 3-4 hours after oral administration. After oral administration, enalapril is subject to hydrolysis and is converted into so-called enalaprilat (active metabolite of enalapril), which exhibits a strong inhibitory effect on ACE.

Half-life of this drug in patients with preserved renal function is 11 hours, while in patients with severe kidney damage (eGFR less or equal 30 ml / min) the half-life is prolonged.

Note: eGFR stands for estimated glomerular filtration rate and is used to measure kidney function.

It is used to treat hypertension and symptomatic heart failure.

Warnings

Acetec should not be used in patients with known hypersensitivity to enalapril. Patients who have had an allergic reaction to any of the ACE inhibitor (e.g. captopril, Renitec, Renitec Plus, lisinopril, cilazapril, ramipril and others) should not use this medicine.

If you have ever had swelling of the lips, face, tongue or throat that have caused you difficulty breathing (so called angioedema), of unknown cause, or due to hereditary factors, then you must avoid use of this medication. Cases of angioedema (including angioedema that may lead to death) have been reported in patients taking this medicine.

Acetec exhibits fetal toxicity, and its use in pregnant women is absolutely contraindicated.

Extra precaution is also necessary in the following situations:

  • If you have or have ever had conditions caused by bone marrow depression, such as:
    • neutropenia (low levels of neutrophils in the blood)
    • thrombocytopenia (low blood platelet count)
    • anemia
    Cases of bone marrow depression associated with the use of this medicine, have been very rarely reported. If you notice symptoms and signs of these disorders, such as: flu-like symptoms (signs of neutropenia), bleeding disorders (signs of thrombocytopenia), or fatigue and paresthesia (signs of anemia), you should contact your physician immediately.
  • If you have high potassium levels or you are taking foods / medicines that can significantly increase your blood potassium levels. Acetec, like all other ACE inhibitors, increases blood potassium levels (hyperkalemia) and hyperkalemia can cause cardiac arrhythmias that can endanger your life. Therefore, tell your doctor if you are taking medicines that increase potassium levels (e.g. eplerenone (brand name Espler), spironolactone, triamterene and amiloride), or if you are on a high-potassium diet (e.g. you're eating a lots of bananas). Also, patients with renal impairment have a higher risk of high blood potassium, and in such patients the use should be performed under the strict supervision of a physician.
  • If you have diabetes mellitus type 1 or type 2. Acetec can cause low blood sugar.
  • If you have systemic lupus.
  • If you suffer from hypotension.
  • If you have rheumatoid arthritis.

Acetec, Pregnancy and Breastfeeding

Acetec should not be used during pregnancy or during lactation.

Dosage

The usual starting dose for the hypertension treatment in adult patients is 5-10 mg once a day.

The usual starting dose for the treatment of symptomatic cardiac insufficiency in adult patients is 2.5 mg once daily.

The usual maintenance dose for the hypertension treatment is 20 mg once daily or divided into two doses (10 mg twice a day).

The usual maintenance dose for the treatment of symptomatic cardiac insufficiency is 20 mg once daily or divided into two doses.

The maximum daily dose is 40 mg.

The recommended starting dose for the hypertension treatment in children who weigh more than 50 kg is 5 mg once daily. The dose may be increased to a maximum of 40 mg daily.

The recommended starting dose for the hypertension treatment in children who weigh 20-50 kg is 2.5 mg once a day. The dose may be increased to a maximum of 20 mg daily.

Swallow the tablets whole, without chewing them and with one glass of water. Tablets are taken regardless of food.

Interactions

Acetec should not be used concurrently with the following drugs:

It should not be used concurrently with alcoholic beverages.

Side effects

Possible side effects of Acetec include:

  • Nausea
  • Dry mouth
  • Fatigue
  • Dizziness
  • Headache
  • Blurred vision
  • Hypotension
  • Arrhythmias
  • Hyperkalemia
  • Paresthesia
  • Aplastic or hemolytic anemia
  • Tinnitus
  • Alopecia
  • Dysuria
  • Reduced gastrointestinal motility and constipation
  • High creatinine levels in the blood
  • Angioedema
  • Cough

References

  1. accessdata link
  2. PIL