Alodorm

Alodorm - Precautions | Dosage | Interactions

Alodorm is a benzodiazepine used most commonly for muscle relaxation in patients who have muscle cramps or muscle stiffness. In addition, it is also used to treat insomnia and very rarely in the treatment of myoclonic seizures. Active ingredient of this medication is nitrazepam.

Its mechanism of action is based on increasing the concentration of gamma-amino butyric acid (GABA), which is the most important inhibitory neurotransmitter. The increase in GABA levels leads to sedative, anxiolytic, myorelaxant and anticonvulsant effect.

Precautions

Alodorm, should not be administered to patients who have diseases that affect muscles (e.g. myasthenia gravis), since it can worsen symptoms of this disease.

It has a depressive effect on the respiratory system, and is therefore not recommended in patients who have acute or chronic pulmonary insufficiency.

Its use is contraindicated in patients with mental disorders (panic-phobic disorders, mania, schizophrenia, etc.).

It should not be applied in patients who have severe liver damage, since it is metabolized by this organ.

Patients who have reduced plasma levels of albumin (hypoalbuminemia) are more sensitive to the activity of this drug, as Alodorm binds to plasma proteins (albumins) in a high percentage. If you don't have enough of this protein in the blood, then the free concentration of Alodorm in the blood will be significantly higher which increases the risk of its side effects.

Alodorm, pregnancy and breastfeeding

Alodorm, like all other benzodiazepines, should not be used during pregnancy because it can adversely affect the breathing in babies immediately after birth.

Small concentrations are excreted into breast milk and may cause excessive sleepiness and therefore use of this drug during lactation should be avoided.

Dosage

The usual dose is 5 mg, half an hour before bedtime.

In patients older than 60 years, the dose should be reduced to 2.5 mg once a day.

It should not be used in children younger than 12 years.

It should never be used together with alcoholic beverages because it emphasizes certain side effects.

Take your pill without regard to the food.

After you take a pill, you should have 6-8 hours of continuous sleep, in order to avoid the occurrence of anterograde amnesia.

Therapy should not last longer than a month because of the risk of physical and / or psychological dependence.

Interactions

It should not be administered concurrently with the following drugs:

  • Levodopa (drug used for the treatment of Parkinson's disease). Alodorm, reduces the efficacy of this drug.
  • Theophylline (a drug used for the treatment of asthma). This medicine can reduce the effect of Alodorm.
  • Probenecid (drug used for the treatment of gout)
  • Antibiotics
  • Anticonvulsants
  • Antipsychotics
  • Opioid analgesics
  • Anesthetics
  • Sedatives
  • Antidepressants
  • H1 antihistamines
  • Baclofen

Adverse reactions

Following adverse reaction may occur while taking Alodorm:

  • Disorientation
  • Respiratory problems
  • Difficulty swallowing
  • Weakness
  • Headache
  • Ataxia
  • Elevated intraocular pressure
  • Double vision
  • Blurred vision
  • Porphyria
  • Nervousness
  • Dystonia
  • Hypotension
  • Withdrawal symptoms
  • Urinary retention
  • Muscle weakness
  • Jaundice
  • Allergy