Aluvia - Dosage | Use | Effects
This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.
Aluvia is a drug that contains a combination of two medicines that have antiviral effect (lopinavir and ritonavir).
It belongs to the antiretroviral group of medicines.
It is used to treat HIV (human immunodeficiency virus, commonly known as AIDS). This medicine is often used in combination with other medicines to treat HIV infection. It can be used in children aged over 2.
It should be avoided in patients allergic to any of the active substances (lopinavir or ritonavir) as well as other similar medicines. If you are experiencing symptoms of an allergy such as:
- redness of the skin,
- difficulty breathing, contact your doctor immediately.
It should be used with extra precautions in patients with high blood cholesterol and high triglyceride level, because this medicament markedly increases cholesterol and triglycerides.
This drug increases the risk of bleeding and therefore should not be used in patients suffering from hemophilia (type A or B).
Aluvia should be used with extra precautions in patients who have had a heart attack or have other heart disorders (e.g. arrhythmia - irregular heart beat).
It may cause pancreatitis (inflammation of the pancreas) and therefore should be avoided in patients with pancreas disorders. If you experience symptoms such as:
- abdominal pain,
- nausea and vomiting,
contact your doctor immediately.
Aluvia can change your blood sugar levels and should be used with extra precautions in diabetic patients. If you are experiencing symptoms such as:
- excessive thirst and frequent urination,
immediately contact your doctor, because it could be a sign of high blood sugar levels.
It may also cause condition called "buffalo hump" (accumulation of fat at the upper back and behind the neck). Fat accumulation may also occur at the chest and abdominal area.
Use during pregnancy and breastfeeding
US Food and Drug Administration classify Aluvia in group C (FDA: Group C). This means that animal studies have shown that Aluvia is harmful to the fetus, but there are no studies on humans. Your doctor will assess the benefits and risks of using during pregnancy.
Women with HIV infection, should avoid breastfeeding the child, in order to avoid virus transmission.
How to use
Aluvia can be taken with or without food. However, it is recommended to take this tablets with food in order to avoid upset stomach. The usual dose of Aluiva tablet to treat HIV infection is 400 mg+100 mg (Lopinavir 400 mg and Ritonavir 100 mg) every 12 hours (twice a day).
Aluvia is found in a dose of 200 mg+50 mg, which means that you need to take two such tablets twice a day. It is also found in a dose of 100 mg+25 mg, but it is mainly intended for use in children.
Tablets can be taken at a dose of 800 mg+200 mg once a day, if your doctor recommends it.
Take tablets whole, with a glass of water. Do not crush tablets because it may change the efficacy of Aluvia tablets.
Aluvia tablets should not be used in combination with alcoholic beverages because alcohol can increase the effect of tablets and cause side effects.
In children, the dose of Aluvia tablet should be calculated according to the child's body weight.
Use with other medicines (Interactions)
Aluvia should be avoided in combination with the following medicines:
- Carbamazepine, phenytoin, phenobarbital, lamotrigine, valproic acid and other medicines used to treat epilepsy.
- Antibiotics, such as:
- telithromycin and others.
- Ketoconazole, itraconazole, clotrimazole, fluconazole and other medicines used to treat fungal infections.
- Medicines used in the treatment of thrombosis (blood thinners) such as:
- warfarin (Farin),
- acenocoumarol (Sinkum 4, Sintrom) and others.
- Colchicine, used in the treatment of gout
- Opioid analgesics (narcotic analgesics), used to relieve severe pain such as:
- fentanyl and others.
- Dexamethasone, prednisolone, methyl prednisolone, budesonide, fluticasone and other corticosteroids.
- Simvastatin (Cholipam), rosuvastatin (Crestor, Mertenil, Rosacta), atorvastatin (Atacor, Atolip, Atoris), lovastatin, fluvastatin and other medicines used to treat high cholesterol (so-called statins). Red rice also contains a substance similar to lovastatin and should be avoided in combination with Aluvia tablets.
- Medicines used to treat erectile dysfunction such as:
- sildenafil (Viagra),
- tadalafil (Cialis) and others.
- Tranquilizers such as:
- midazolam (ksalol),
- St. John's wort and various products made from this herb.
- Cisapride, used to treat gastrointestinal disorders
- Ergot alkaloids such as:
- methyl ergometrine and others. These medicines are used to treat migraines. Aluvia tablets could worsen the migraines.
- Medicines used for the treatment of autoimmune diseases such as:
- tacrolimus and others.
Tell your doctor about all medications and herbal medicines you are taking.
Aluvia side effects
Aluvia can cause the following side effects:
- respiratory tract infections (occurs frequently),
- decrease in the number of white blood cells (leukopenia),
- high blood cholesterol,
- high blood triglycerides,
- lymphadenopathy (enlargement of the lymph gland),
- weight loss,
- liver damage accompanied by jaundice-yellowing of the eyes and skin,
- hair loss (alopecia),
- erectile dysfunction,
- menstrual cycle disorders,
- allergy and others.
Tell your doctor if you are experiencing any of abovementioned side effects.
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If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.