Amlopin

Amlopin - Use | Dose | Side Effects

Amlopin is medication from the group of dihydropyridine calcium channel antagonists that is used to treat hypertension and angina pectoris. Studies have shown that it is effective for long-term treatment of hypertension, even in patients with concomitant diabetes and renal impairment.1

Because of its high bioavailability and 40 h half-life, it is best to take it once a day. When you take the tablet, your blood pressure will decrease gradually in next 6 hours. It can lower your blood pressure approximately for 10 % (e.g. if your systolic blood pressure is 200 mmHg than Amlopin will lower your blood pressure for 20 mmHg).

It is one of the most effective medicine with very good safety profile in nowadays used in the treatment of hypertension

Warnings

As we said before, this medicine have very good safety profile because it rarely causes adverse effects and if causes some, they are usually mild and don't last for long. It is one of the rare medications which dosage regimen doesn't need any adjustments in patients with renal impairment. On contrary, this medicine has proven safety in these patients. However, there are not enough data whether dose adjustment is needed in patients with hepatic impairment.

Since this medicine slow down the heart rate, it must not be used in patients who have slow heartbeat (bradycardia) or cardiogenic shock. It must not be used in patients with low blood pressure.

Studies have shown that it can be safely used in elderly patients.

This medicine is prescription-only medicine and you need to talk to your doctor and inform him about all diseases/conditions you have prior treatment.

We found only one case of an intentional overdose of Amlopin (patient took about 100 mg of this medicine - 10 times more than recommended daily dose) and this patient experienced pulmonary edema.2 Never take more tablets than recommended by your doctor.

Amlopin and its use in pregnant and lactating woman

Although this medicine is often prescribed during pregnancy, there are not enough data to support its use during pregnancy. Your doctor will decide which medication is best for treating hypertension during pregnancy.

Amlopin is transferred into the breast milk which is why its use in lactating woman is not recommended.

How to use

Maximum daily dosage is 10 mg. Never take more than 10 mg per day.

Usual recommended dose is 5 mg taken once a day, usually around the noon.

You can take this medicine with meal in order to prevent gastrointestinal adverse effects.

Simultaneously administration of Amlopin and other drugs

Simultaneously administration of Amlopin with following drugs should be avoided:

  • Simvastatin (inhibitior of HMG CoA reductase). Simvastatin is a medicine that lowers your cholesterol levels. Simultaneously administration of Amlopin and Simvastatin increase bioavailability of Simvastatin which may lead to its adverse effects (myalgia for example)
  • Dolasteron, a 5 HT3 serotonin antagonist, used to treat nausea in patients receiving chemotherapy
  • Anifungal agents, such as: itraconazole and ketoconazole.
  • Sitagliptin (anti-diabetic medicine)
  • Tizanidine (a muscle relaxant)
  • Isoniazid and rifampin (medicines used to treat tuberculosis)

Note: Above we mentioned only medications that may have major interaction with Amlopin. This list is not complete list of all medicines that can interact with Amlopin. You need to tell your doctor if you are taking any other medications, including herbal and other OTC products.

Adverse effects

We will repeat again, that this medicine is well tolerated and has very good safety profile. However, you should know what are the potential adverse effects of Amlopin:

  • Dysgeusia (lost of taste sensation)
  • Feeling of warmth
  • Eye irritation
  • Headache
  • Pancreatitis
  • Pain in your stomach
  • Decreased sensation of appetite
  • Swelling
  • Low blood pressure
  • Erectile dysfunction
  • Joint ache
  • Muscle ache
  • Weight gain or weight loss
  • Nerve damage
  • Spasticity

For more information about Amlopin side effects, you can visit this link