Amoksiklav - Information about medicine

Amoksiklav belongs to the group of medicines called penicillin antibiotics. It contains amoxicillin and clavulanic acid, which increases the effect of amoxicillin. Clavulanic acid blocks the enzyme known as beta-lactamase (created by bacteria).

Beta-lactamase causes degradation of ampicillin. By reducing the effect of this enzyme, clavulanic acid increases the effect of amoxicillin and therefore represents a very effective antibiotic. This medicine works against both gram positive and gram negative bacteria. It is used in the treatment of the following infections:

  • Respiratory tract infections (sinusitis, laryngitis, pneumonia, bacterial bronchitis, pharyngitis)
  • Middle ear infection (otitis media)
  • Urinary tract infections (cystitis, pyelonephritis)
  • Bone and joint infections
  • Skin and soft tissue infections


Amoksiklav cannot be used in patients allergic to penicillin and amoxicillin or other cephalosporin antibiotics such as:

  • penicillin,
  • ampicillin,
  • amoxicillin,
  • cefaclor,
  • cefazolin,
  • cephalexin (Palitrex),
  • ceftriaxone (Longacef),
  • cefuroxime and others. If you experience symptoms of an allergy such as:
    • skin rash,
    • itching,
    • redness,
    • swelling of the face,
    • swelling of the tongue,
    • trouble breathing, contact your doctor immediately.

It cannot be used in patients with liver disorders, considering that Amoksiklav may additionally damage the liver and exacerbate the condition in such patients. If you experience symptoms of liver damage, such as:

  1. dark urine,
  2. loss of appetite,
  3. jaundice (yellowing of the skin and eyes), contact your doctor immediately.

It should be used only with great caution in patients with renal disorders because this medicine can cause seizures (convulsions) in such patients.

Like all other antibiotics and Amoksiklav may change the gut flora and lead to the colitis (inflammation of the colon). If you experience diarrhea, you will need to stop using this drug and contact your doctor.

It is very important to use this medicament for an appropriate time period, as long as your doctor recommended (usually 7-10 days). In this way you will prevent occurrence of Amoksiklav-resistant bacteria.

Keep in mind that Amoksiklav may affect lab test results.

If you are planning surgery, inform your doctor that you are using Amoksiklav.

Before you start taking this drug, you will need to do an antibiogram to determine the exact causes of infection.

Use during pregnancy and breastfeeding

Amoksiklav can be used during pregnancy only if the benefit to the mother outweighs the risk to the child. Some animal studies have shown that it have no harmful effects in pregnancy.

Avoid breast-feeding while using this drug, because Amoksiklav passes into breast milk. You can give your baby formula milk instead of breast milk, while using Amoksiklav.

How to use

The dose depends on the body weight and severity of the infection.

In adults and children weighing more than 40 kg dose is Amoksiklav 625 mg (500 + 125 mg) three times a day.

In children weighing less than 40 kg, the dose should be reduced. The dose should be calculated based on the child body weight. In children, it is recommended the use of Amoksiklav syrup.

It must be taken with meals to reduce the risk of stomach side effects.

Use with other medicines (Interactions)

It cannot be used concomitant with the following medicines:

  • Blood thinners (so called anticoagulant medicines) such as:
    • warfarin (Farin),
    • acenocoumarol (Sinkum 4),
    • nadroparin (Fraxiparine) and others. The concomitant use of these medicines with Amoksiklav increases the risk of bleeding. It is necessary to reduce the dose of anticoagulant medicines if you have to use Amoksiklav.
  • Methotrexate, used to treat cancer and autoimmune diseases. Amoksiklav reduces methotrexate excretion, and therefore can lead to the accumulation of methotrexate causing side effects.

Tell your doctor about all medications and herbal medicines you are taking.

Side effects

Amoxiclav may cause the following side effects:

  1. nausea,
  2. vomiting,
  3. diarrhea (which may be accompanied by blood),
  4. colitis (inflammation of colon),
  5. headache,
  6. dizziness,
  7. Steven-Johnson syndrome (a life-threatening skin disorders-occurs very rarely),
  8. lowered white blood cells (agranulocytosis),
  9. low blood platelet count (thrombocytopenia),
  10. anemia,
  11. allergy and others.

Tell your doctor if you experience any side effect.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.