Ampril - Use | Dose | Side Effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Ampril is a drug that contains an active substance called ramipril. It belongs to the group of medicines called angiotensin-converting enzyme (also known as ACE inhibitors).

Also it belongs to the one of the most commonly used drugs to treat high blood pressure (hypertension) and heart failure. In addition, it may be used for prevention of complications in patients who have had a heart attack or stroke. It may be used in patients with kidney failure (especially in patients with diabetes), as Ampril has shown a number of beneficial effects in those patients.

This medicine works by blocking the angiotensin converting enzyme and thereby prevents the body from creating a substance called angiotensin. Preventing the creation of this substance, Ampril lowers high blood pressure.


  • It should be avoided in patients who are allergic to the active substance (ramipril) or other similar drugs such as:
    • enalapril,
    • captopril,
    • cilazapril,
    • lisinopril,
    • fosinopril and others. If you are experiencing symptoms of an allergy, such as:
      • skin rash,
      • itching,
      • swelling of the face,
      • swelling of the tongue,
      • difficulty breathing, contact your doctor immediately.
  • This medicine should be avoided during pregnancy because it may harm your unborn baby.
  • Ampril should be avoided in patients who have or have ever had swelling of the skin, swelling of the throat or swelling of gastrointestinal organs, especially if the edema (swelling) was caused by other medicines.
  • It should be avoided in patients with narrowed or blocked kidney blood vessels (so called renal artery stenosis).
  • It should be avoided in patients with low blood pressure.
  • Ampril should be used only with extra precaution in patients with liver cirrhosis and in patients who are dehydrated or are deficient in the body's water supply. In such patients, Ampril may disturb the electrolyte balance and cause hyperkalemia (high levels of the potassium in the blood).
  • Bear in mind that this drug may often cause dry cough. If dry cough is persistent, your doctor may recommend you to take other medicine instead of Ampril.
  • It may cause hyperkalemia (high levels of potassium in the blood). High levels of potassium in the blood can lead to the heart disorders, which is why you need to contact your doctor if you notice any changes in the way your heart work. While using Ampril you should avoid the potassium supplements. Also, you should avoid using potassium rich foods in larger quantities (bananas, prunes).
  • If you are planning surgery, tell your doctor that you are using Ampril.
  • Amprilan can cause swelling, and it is necessary to immediately contact your doctor if you notice swelling anywhere on your body.
  • Amprilan can, although very rarely, cause agranulocytosis (severe reduction in the number of white cells), which can negatively affect your immune system. If you notice flu-like symptoms such as:
    • cough,
    • fever,
    • sore throat, contact your doctor and check your number of white blood cells with certain laboratory tests.

If you are experiencing dizziness while using this drug, avoid driving and using machines.

Use during pregnancy and breastfeeding

Amprilan should be avoided during pregnancy and breastfeeding because it may harm your baby! Discuss with your doctor about the benefits and risks of using this medicine during pregnancy and breastfeeding.

How to use

Amprilan can be taken regardless of food, but you need to swallow (do not chew) as this may affect Ampril effect.

It should be taken every day at the same time. The initial dose should be as low as possible and can be increased until a proper effect is achieved. If you are already using water pills (also known as diuretics), you would need to stop use these medicines and few days after you can start using Ampril.

The usual initial dose of Ampril is 1.25 mg-2.5 mg once a day, every day at the same time. The dose can be increased as necessary to 10 mg once a day.

Amprilan can be used twice a day (at the morning and at the evening) if your doctor tells you so.

Dose need to be reduced in elderly patients as well as in the patients with severe renal failure.

Amprilan should be avoided in children.

Use with other medicines (Interactions)

It should be avoided in combination with the following medicines:

  • Potassium supplements. Concomitant use of these supplements with Ampril, may lead to a dangerous increasing in blood potassium levels and cause heart disorders.
  • Water pills (diuretics) such as:
    • spironolactone,
    • triamterene,
    • amiloride. These drugs also may lead to increased potassium levels in the blood, and therefore should be avoided in combination with Ampril.
  • Corticosteroids, drugs that are used to treat inflammation such as:
    • dexamethasone,
    • prednisolone,
    • methylprednisolone and others. Concomitant use of these medications with Ampril, increases the risk of agranulocytosis (severe reduction in the number of white blood cells), causing a decreasing of immune system.
  • Immunosuppressants and cytostatic drugs, used to treat cancer and autoimmune disorders. Concomitant use of these medicines increases the risk of agranulocytosis (severe reduction in the number of white blood cells), which can negatively affect your immune system.
  • Lithium, a medicine used in the treatment of depression. Ampril can increase lithium levels in the blood and lead to lithium side effects.
  • Other ACE inhibitors and AT blockers such as:
    • enalapril,
    • captoril,
    • cilazapril,
    • fosinopril (Monopril),
    • lisinopril,
    • losartan,
    • valsartan,
    • candesartan and others. Concomitant use of these medicines with Ampril may enhance the action of these medicines and cause side effects.
  • Non-steroidal anti-inflammatory drugs (NSAID) used in the treatment of pain and inflammation such as:
    • diclofenac (Diklofen),
    • ibuprofen (Brufen),
    • ketoprofen,
    • naproxen,
    • sulindac,
    • meloxicam (Movalis),
    • flurbiprofen and others. These drugs reduce the effect of Ampril and may lead to the lack of the efficacy.

Tell your doctor about all medications and herbal medicines you are taking.

Side effects

Amprilan could cause following side effects:

  1. dry cough (occurs very often),
  2. an increase of potassium levels in the blood (occurs frequently),
  3. headache,
  4. dizziness,
  5. flushing,
  6. taste disorder,
  7. abnormal vision,
  8. conjunctivitis,
  9. increased sensitivity to sunlight (photosensitivity),
  10. angioedema (swelling),
  11. nausea,
  12. vomiting,
  13. diarrhea,
  14. Stevens-Johnson syndrome (a life-threatening skin disorder, occurs very rarely),
  15. mood changes (depression, anxiety),
  16. agranulocytosis (severe reduction in number of white blood cells),
  17. anemia and allergy.

Tell your doctor if you notice any of abovementioned side effects.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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