Analgin

Analgin - dosage | side effects | overdose

Category Pyrazolones

Analgin drug is from the group of pyrazolones. It contains an active compound called metamizole. It works by reducing the pain and fever (antipyretic and analgesic).

This drug is used in the following conditions:

  • Treatment of severe pain, usually after surgery.
  • In the treatment of severe pain in patients with cancer.
  • Treatment of severe stomach pain.

It is used only in the treatment of severe pain. Analgin tablets should be avoided in the treatment of mild to moderate pain.

It can cause serious side effect called agranulocytosis (very low white blood cells count). Your body has defense system against pathogens that make you sick. That defense system is actually leukocytes.

When you have a low white blood cells count you may be immunosuppressed which means that you have increased risk of developing a potentially life threatening infection and sepsis. These infections and sepsis have been very difficult to treat and can be fatal.

Therefore, this medicament should be used only when clearly needed.

Precautions

It should be avoided or may be used only with extra precautions in the following conditions:

  • If you are allergic to Analgin or other similar drugs. Symptoms of an allergy include:
    • skin rash,
    • itching of the skin,
    • redness of the skin,
    • swelling of the throat, face and tongue
    • difficulty breathing.
    • An allergic reaction can cause anaphylactic shock, that can be fatal.
  • Bone marrow disorders or a history of agranulocytosis or other similar disorders (anemia, eosinophilia, and others)
  • Liver disorders.
  • If you are under 15 years of age
  • Asthma
  • Low blood pressure (hypotension)

This medicine, as we have already mentioned can cause dangerous agranulocytosis. It can cause sudden collapse of circulatory system, which may lead to shock. This drug should not be used in combination with alcoholic beverages.

Use during pregnancy and breastfeeding

Analgin should not be used during the first and last trimester of pregnancy. During the second trimester of pregnancy it may be used only if clearly needed.

Avoid breastfeeding while using this medicine. When you stop using this drug, you should be able to breastfeed your baby in 2 days.

Analgin dosage

Analgin dose depends on the severity of pain. The usual dosage is Analgin 500 mg up to 1000 mg several times a day (no more than 5 times a day!). The maximum daily dose is 5 000 mg!

You should not take this drug for more than 5 days.

Swallow the tablets whole. Do not crush it. It should be taken with a glass of water.

Analgin usually begins to act after 30 minutes

Analgin overdose

Symptoms of an analgin overdose include:

  • nausea,
  • vomiting,
  • dizziness,
  • fainting,
  • low blood pressure,
  • heart disorders,
  • abdominal pain,
  • kidney damage,
  • pink colored urine.

Immediately contact your doctor if you take more Analgin than your doctor recommended.

Use with other drugs (Interactions)

Analgin should be avoided or may be used only with extra precautions with the following medications:

  • Medications used in the treatment of blood clotting disorders (thrombosis and other disorders):
    • warfarin (Farin),
    • acenocoumarol (Sintrom, Sinkum 4),
    • heparin,
    • nadroparin (Fraxiparin) and other similar medications. Concomitant use of Analgin with these medications increases the risk of bleeding.
  • Corticosteroids such as:
    • dexamethasone,
    • prednisolone,
    • methylprednisolone,
    • fluticasone and others.
  • Medications used in the treatment of infections (antibiotics):
    • sulfonamides (Bactrim),
    • penicillins,
    • ampicillin (Pentrexyl),
    • amoxicillin (Sinacilin),
    • amoxiclav (Panklav) and other similar medications.
  • Methotrexate used in the treatment of breast cancer.
  • Medications used in the treatment of diabetes:
    • metformin (Gluformin),
    • glibenclamide,
    • glipyride,
    • gliclazide, and other similar medications.

Tell your doctor about all the medications and herbal preparations you are taking.

Analgin side effects

Analgin may cause the following side effects:

  1. nausea,
  2. vomiting,
  3. headache,
  4. dizziness,
  5. kidney damage,
  6. pink colored urine,
  7. abdominal pain,
  8. choking,
  9. dry mouth,
  10. low blood pressure (hypotension),
  11. agranulocytosis and allergic reactions.

The most dangerous side effect of Analgin is certainly agranulocytosis (very low WBC count). Your body has defense system against pathogens that make you sick. That defense system is actually leukocytes.

When you have a low white blood cells count you may be immunosuppressed which means that you have increased risk of developing a potentially life threatening infection and sepsis. These infections and sepsis have been very difficult to treat and can be fatal.

It is therefore necessary to immediately contact a doctor if you notice symptoms of a cold or flu:

  1. sore throat,
  2. fever,
  3. cough,
  4. runny nose and other symptoms. This may be a sign that agranulocytosis occurred.