Antroquoril cream

Antroquoril cream - How to use | Interactions

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Antroquoril cream is a topical preparation that contains a strong corticosteroid called betamethasone dipropionate. It is most commonly used for treating various forms of dermatitis (atopic dermatitis, neurodermatitis, eczematoid nummular dermatitis, dyshidrotic dermatitis, seborrheic dermatitis, x-ray dermatitis, photodermatitis, non-allergic dermatitis and diaper dermatitis). Its application has also been approved for the treatment of psoriasis and eczema.

A clinical trial conducted on 180 patients with psoriasis has shown that this cream has a superior effect in the treatment of psoriasis when compared to the control group.


Betamethasone is classified as a potent corticosteroid (Class 2), and duration of its use must be limited.

Prolonged use over large areas of the skin increases the risk of betamethasone absorption in the systemic circulation, which can cause serious systemic adverse effects, such as:

  • Sudden increase in the cortisol levels (so-called, Cushing's syndrome). Symptoms of Cushing's syndrome include:
    • rapid weight gain in the neck and face (which leads to moon-shaped face)
    • swollen hands and feet
    • fat accumulation in the upper neck and back (so-called buffalo hump) and emotionally instability
  • Suppression of the hypothalamic-pituitary-adrenal axis, which leads to occurrence of symptoms, such as:
    • unconsciousness
    • syncope
    • hypoglycemia
    • anorexia
    • weight loss
  • Carbohydrate intolerance, which can induce hyperglycemia. For this reason, the use of this cream in diabetics must be limited to small areas of the skin and should not be used for longer than three days.
  • Elevated intraocular pressure and glaucoma, which is manifested by the following symptoms: blurred vision and visual haloes around lights. Studies have shown that betamethasone is one of the most potent corticosteroids in producing cataracts and glaucoma. Visual impairment resulting from the use of this cream is reversible and quickly disappears if the cream is only used for short periods of time.
  • Avascular necrosis of the femoral head. Betamethasone can cause intravascular coagulation, which may impede blood supply to the bone. Since blood does not reach the femur, this bone does not get the necessary nourishment and this leads to its necrosis and destruction. It is very important that you contact your doctor if you are experiencing bone pain or inflammation.
  • Slowing of growth in children

The application of this cream in children younger than 16 years should be avoided.

Antroquoril cream should not be applied if you have any of the following conditions

  • Acne
  • Rosacea
  • Skin tuberculosis
  • Dermatitis that develops around the mouth or anal-genital region
  • Viral infections of the skin (e.g. herpes)
  • Hemorrhoids
  • Measles

The application of this cream to the area around the eyes should be avoided.

Antroquoril cream decreases the content of collagen in the subcutaneous tissue and can lead to the appearance of stretch marks, especially on parts of the skin that are prone to developing stretch marks (groin, armpits and the skin around the anal area).

Antroquoril cream, pregnancy and breastfeeding

The FDA classifies this cream in the group C, because clinical studies on rabbits have shown that the use of this drug during pregnancy may have a teratogenic effect. For this reason, use of Antroquoril cream during pregnancy should be avoided.

It is not known whether this cream is excreted into breast milk or not, but due to the risk of serious systemic adverse effects that can occur in infants, use of this cream during breastfeeding should be avoided.

How to use

Antroquoril cream is applied twice daily to the affected area. Apply a thin layer and gently rub into skin.

Do not cover the skin with a bandage, plaster or tight clothing, because it increases the absorption of betamethasone into the blood.

After applying, be careful not to touch your eyes. If Antroquoril cream gets into your eyes, flush your eyes with cold water for at least 15 minutes.


Antroquoril cream does not interact with other drugs.

Side effects

Antroquoril cream very rarely causes systemic side effects that are described earlier in the text (see Preacutions). Systemic side effects generally occur when Antroquoril cream is used long-term and over large areas of the skin. These side effects are generally reversible and disappear quickly after treatment discontinuation and rarely leave permanent consequences.

In addition to the systemic adverse effects, Antroquoril cream can also cause local side effects, such as:

  • Ecchymosis
  • Irreversible stretch marks
  • Local hyperpigmentation
  • Increased hair growth at the site of application
  • Itching
  • Rash
  • Depigmentation of the skin
  • Acne
  • Irritation of the skin


  1. NCBI link 1
  2. NCBI link 2
  3. NCBI link 3

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If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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