Arketis

Arketis - use | dosage | effects

Arketis is medicine that contains an active substance called paroxetine. It belongs to group of medicines called selective serotonin reuptake inhibitors. Paroxetine also belongs to the group of antidepressants. It is used in the treatment of obsessive-compulsive disorder, depression, anxiety, post-traumatic stress disorder and social phobia.

Precautions

  • It should be avoided in patients allergic to paroxetine or other similar drugs, such as:
    • fluoxetine,
    • citalopram and others
    • If you are experiencing symptoms of an allergy:
      • itching,
      • redness,
      • swelling,
      • difficulty breathing, contact your doctor immediately.
  • It should be avoided in combination with other drugs used to treat depression (MAO inhibitors), such as:
    • moclobemide,
    • selegiline,
    • phenelzine,
    • tranylcypromine,
    • isocarboxazid, and others. If you are taking MAO inhibitors, you will need to stop using these medicines and after 14 days you can start using Arketis pills. It is very important to avoid concomitant use of these medicines because serotonin syndrome may occur. Serotonin syndrome may have a fatal outcome. Symptoms of serotonin syndrome include:
      • high fever,
      • irregular heartbeat (arrhythmia),
      • seizures,
      • loss of consciousness,
      • confusion,
      • sweating,
      • headache and others. Tell your doctor if you are experiencing any of these symptoms.
    • It should be avoided in patients under the age of 18.
    • Do not stop using Arketis abruptly, because withdrawal syndrome may occur!
    • If you have a feeling described as "inability to sit" (akathisia), your doctor will probably recommend you to change a medicine.

If you are using pimozide, medicine used in the treatment of psychosis, then you should avoid concomitant use with Arketis.

Arketis should be used with extra precautions in the following conditions:

  • Patients with epilepsy.
  • Severely impaired liver or kidney function.
  • In patients with bleeding.
  • Diabetes mellitus.

Patients experiencing suicidal thoughts, must immediately contact their doctor to change the medication.

It is also necessary to train the patient's family, if they notice behavior changes in patient, to immediately report it to the doctor.

Use of Arketis during pregnancy and breastfeeding

It should be avoided during pregnancy, especially in the last three months of pregnancy. If used in the last three months of pregnancy, paroxetine may cause the following symptoms in newborns:

  • difficulty breathing,
  • blue lips,
  • vomiting,
  • muscle cramps, and others. It can be used during pregnancy only if the benefit to the mother outweighs the risk to the child.
  • Arketis passes into breast milk and may harm your baby. Avoid breastfeeding while using this drug.
  • It may change the quality of sperm, about what patients planning pregnancy should be warned.

Arketis use and dosage

  • It tshould be used in the morning with breakfast. Arketis should be swallowed whole with 250 ml of water. Do not chew or crush the tablet, as this may affect its efficacy.
  • Usual dose is Arketis 20 mg to 60 mg per day. Maximum daily dose should not exceed 60 mg per day!
  • Treatment should be started with the lowest dose, which could be gradually increased until desired effect is achieved. The usual initial dose is 20 mg once a day in the morning, during breakfast.
  • It is necessary to use this medicine for a long time to start feeling the improvement (sometimes it takes several months).
  • In elederly, the dose of Arketis should not exceed 40 mg daily.

Use with other medications (Interactions)

It should be avoided in combination with the following drugs:

  • MAO inhibitors, such as:
    • moclobemide,
    • tranylcypromine,
    • isocarboxazid,
    • phenelzine and others. Concomitant use with these drugs can cause severe serotonin syndrome. If you are taking MAO inhibitors, you will need to stop using these medicines and after 14 days you can start using Arketis.
  • Non steroidal anti inflammatory drugs, such as:
    • acetylsalicylic acid (Aspirin),
    • ibuprofen (Brufen),
    • meloxicam (Movalis),
    • celecoxib,
    • etoricoxib,
    • diclofenac (Diklofen) and others.
  • Pimozide, used to treat mental disorders.
  • Medicines used in the treatment of migraine, such as:
    • sumatriptan,
    • rizatriptan,
    • zolmitriptan, and others.
  • Drugs used in the treatment of blood clotting disorders (so-called blood thinners), such as:
    • warfarin (Farin),
    • acenocoumarol (Sinkum 4), and others.
  • Medicines used in the treatment of severe pain (narcotic analgesics), such as:
    • tramadol (Trodon),
    • pethidine,
    • fentanyl and others.
  • Drugs used in the treatment of HIV (AIDS), such as:
    • ritonavir,
    • fosamprenavir and others.

It should be avoided in combination with alcohol. Tell your doctor about all medications and herbal products you are taking.

Arketis side effects

It may cause the following side effects:

  1. suicidal thoughts,
  2. behavior changes,
  3. mood changes,
  4. akathisia,
  5. hallucination,
  6. nausea,
  7. vomiting,
  8. diarrhea,
  9. headache,
  10. dizziness,
  11. loss of appetite,
  12. weight gain,
  13. dry mouth,
  14. blurred vision,
  15. elevated blood cholesterol,
  16. sexual dysfunction,
  17. painful erections,
  18. photosensitivity (increased sensitivity to sunlight),
  19. allergy and others.

Tell your doctor if you are experiencing any side effects.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.