Atoris | Cholesterol - lowering medicine
Category HMG-COA reductase inhibitors
Atoris is a drug that contains an active substance called atorvastatin.
This medicine belongs to the group called HMG-CoA reductase inhibitors also called statins.
Atoris works by blocking this enzyme, thereby lowering the levels of "bad" cholesterol (LDL) in the blood. It also increases the levels of "good" cholesterol (HDL) in the blood, therefore it is used in the treatment of hypercholesterolemia (high cholesterol levels).
In addition to this medication administration, it is also necessary to change your lifestyle, especially diet.
You need to avoid fatty and heavy meals, and increase the intake of fish meat, fruit and vegetables. High cholesterol often causes no symptoms, but it presents a big risk factor for heart attack and stroke.
- It should be avoided in the following conditions:
- Patients allergic to the active substance atorvastatin or other similar drugs.
- In patients with liver disorders. It may cause liver damage and thus worsen the condition in such patients.
- Patients with muscle disorders. Atoris may cause rhabdomyolysis (serious muscle damage).
- It should not be used during pregnancy and breastfeeding.
- At the beginning of therapy, your doctor may recommend to you to often check your liver function doing some laboratory tests (such as AST or ALT) in order to assess whether the Atoris is harmful to your liver. If there is a great increase in AST and ALT levels in the blood, your doctor may recommend you to stop using this medicine. If you are experiencing symptoms of liver damage, such as:
- loss of appetite,
- abdominal pain,
- jaundice (yellowing of the skin and eyes), contact your doctor immediately.
- It may, although very rare, cause a rhabdomyolysis (severe muscle damage). If you are experiencing symptoms such as:
- muscle pain,
- muscle cramps or muscle weakness that may be accompanied by high fever, contact your doctor immediately, as this may be a sign that rhabdomyolysis has occurred.
- This drug should not be used in combination with alcohol, because alcohol may hamper Atoris effects.
Use during pregnancy and breastfeeding
It should not be used during pregnancy because it may harm your unborn baby and cause malformations. Also avoid breastfeeding while using this mediaction, because Atoris passes into breast milk and may harm your baby.
Use and Dosage
It should be taken once a day in the evening, before going to bed, because Atoris has shown better effect if used in the evening.
Initial dose is usually Atoris 10 mg once a day. Dose can be increased until you reach desired effect. It should be taken for a long time.
As we said before you will also need to change your lifestyle and diet to achieve the best effect and preserve your health.
Use with other medicines (Interactions)
This medicine should be avoided in combination with the following:
- Medications used for the infection treatment (antibiotics), such as:
- telithromycin, and others. These drugs may enhance the effects of Atoris and cause side effects (especially rhabdomyolysis).
- Medications used for the fungal infection treatment, such as:
- fluconazole, and others. Concomitant use of these medications increases the risk of rhabdomyolysis.
- Medications used for the HIV treatment, the so-called inhibitors of HIV protease, such as:
- indinavir, and others. These medications enhance the effect of Atoris and may cause rhabdomyolysis.
- Niacin, a drug that is also used for the treatment of hypercholesterolemia. Concomitant use with this drug increases the risk of rhabdomyolysis and liver damage.
- Immunosuppressive agents, such as cyclosporine. Concomitant use with this drug increases the level of Atoris in the blood and therefore increases the risk of side effects.
- Oral contraceptives. It can increase the level of oral contraceptives in the blood.
- Amlodipine, a drug used for the treatment of hypertension and angina pectoris. Concomitant use of Amlodipine may increase the level of Atoris in the blood and cause adverse effects.
It should be avoided in combination with grapefruit juice, because grapefruit juice may increase the effect.
Atoris side effects
It may cause the following side effects:
- abdominal pain,
- upset somach,
- bloating (flatulence),
- increased blood sugar levels (hyperglycemia),
- liver damage,
- muscle damage (rhabdomyolysis),
- decrease in the platelet count (thrombocytopenia),
- hair loss (alopecia),
- hearing loss,
- mood swings,
- sexual dysfunction,
- memory loss,
- allergy and others.
Tell your doctor if you are experiencing any side effects.