Brufen

Brufen - Use | Dose | Side Effects

Brufen is medicine that contains an active substance called ibuprofen. It belongs to a group of non steroidal anti inflammatory drugs (NSAIDs). It has analgesic effect (relieves pain), anti-inflammatory effect (reduces inflammation in the body) and antipyretic effect (reduces fever).

It is used to relieve mild to moderate pain (headache, toothache, menstrual pain). It is also used to treat rheumatic diseases.

It can be used in the treatment of the following conditions:

  • Rheumatoid arthritis
  • Ankylosing spondylitis (inflammation of the joints in the spine)
  • Osteoarthritis, a chronic disease of the joint leading to pain and immobility.
  • Tendinitis (inflammation of a tendon). The tendon is a tissue that connects muscle to bone.
  • Bursitis (inflammation of bursae). Bursa is a small, fluid-filled sac, located inside the joints and acts as a cushion between a bone and other parts of the body. Bursitis occurs most often in the elbow, shoulder, hip, knee and heel. It is characterized by pain that occurs when pressed.
  • Capsulitis (also called "frozen shoulder syndrome"). It is characterized by shoulder pain and limitation of shoulder movement.

Precautions

Brufen should be avoided in the following conditions:

  • In patients allergic to the active substance ibuprofen or other NSAIDs, such as:
    • ketoprofen,
    • flurbiprofen,
    • diclofenac,
    • indomethacin,
    • acetylsalicylic acid (Aspirin)¬†and other. If you are experiencing symptoms of an allergy, such as:
      • itchy skin,
      • skin rash,
      • redness,
      • swelling or difficulty breathing, contact your doctor.
  • Patients with gastric or duodenal ulcer.
  • In patients with severe hepatic or renal impairment
  • During pregnancy, especially in the last three months of pregnancy
  • In patients with heart diseases
  • In patients with asthma, because this medicine can cause bronchospasm (narrowing of bronchi) and lead to an asthma attack

Brufen can inrease risk of heart attack and stroke, especially if you use this medicine long term or take high doses! This medicine should be used for the shortest possible time.

It should not be used in combination with alcoholic beverages, because alcohol increases the risk of gastrointestinal bleeding.

Use of Brufen during pregnancy and breastfeeding

Brufen should be avoided during pregnancy, especially in the last three months of pregnancy because it can cause birth defects!

Avoid breastfeeding while using this medicine.

Use and Dose

Ibuprofen dosage forms include:

  • Brufen 200 mg,
  • Brufen 400 mg,
  • Brufen 600 mg,
  • Brufen 800 mg
  • and Brufen syrup.

The dose depends on the condition. The usual dose is 600-1800 mg per day. in divided doses (e.g. 600 mg, 3 times a day). The maximum daily dose is 2400 mg! It should be taken after a meal, in order to reduce stomach upset.

Dosage:

Age Dose
Children aged 7-10 years 200 mg, three times a day
Children aged 10-12 years 200 mg, 3-4 times a day
Children aged 12-18 years 200-400 mg, 3-4 times a day

Dosage of Brufen syrup in children:

Age Dose
Children aged 1-2 years 2.5 ml, 3-4 times a day
Children aged 3-7 years 5 ml, 3-4 times a day
Children aged 8-12 years 10 ml, 3-4 times a day

In children, Brufen can be dosed according to body weight, wherein the dose is 30-40 mg / kg of body weight per day, divided in 3-4 doses. Example: If your childs body weight is 20 kg, the dose can be calculated as following:

30 mg x 20 kg = 600 mg per day in divided doses (e.g., 200 mg three times a day).

Use with other medicines (Interactions)

Brufen should be avoided in combination with the following medicines:

  • Medicines used in the treatment of heart diseases, such as:
    • metoprolol (Presolol),
    • atenolol,
    • bisoprolol (Concora),
    • carvedilol,
    • propranolol,
    • captopril,
    • enalapril,
    • ramipril (Tritace),
    • lisinopril,
    • cilazapril,
    • quinapril (Hemokvina),
    • hydrochlorothiazide,
    • furosemide (Lasix),
    • spironolactone,
    • torasemide,
    • triamterene,
    • amiloride and others. Brufen may reduce the effect of these medicines!
  • Mifepristone, used to terminate a pregnancy. Brufen may reduce the effect of this medicine.
  • Digoxin (Dilacor), a medicine used to treat heart failure. Brufen may increase the levels of the Digoxin in the blood, increasing the risk of side effects.
  • Lithium, medicine used in the treatment of depression. Brufen may increase the level of Lithium in the blood, increasing the risk of side effects.
  • Methotrexate, medicine used in the treatment of cancer.
  • Cyclosporin, medicine used in the treatment of autoimmune diseases.
  • Zidovudine, medicine used in the treatment of virus infections including HIV (AIDS). Concomitant use of this medicine with Brufen, increases the risk of hematoma and haemarthrosis.
  • Warfarin (Farin), medicine used in the treatment of thrombosis. Concomitant use of the Brufen with this medicine, increases the risk of bleeding.
  • Other non steroidal anti-inflammatory drugs (NSAIDs), such as:
    • ketoprofen,
    • diclofenac,
    • indomethacin,
    • flurbiprofen,
    • nimesulide,
    • acetylsalicylic acid (Aspirin) and others. Concomitant use of Brufen with these medicine, increases the risk of stomach bleeding.
  • Corticosteroids, medicines used in the treatment of numerous inflammatory conditions, such as:
    • prednisolone,
    • dexamethasone and others. Concomitant use of these medicine with Brufen increases the risk of stomach bleeding.
  • Medicines used in the treatment of diabetes, such as:
    • metformin,
    • gliclazide,
    • glimepiride,
    • glibenclamide,
    • repaglinide and others. Concomitant use of Brufen with these medicines, increases the risk of hypoglycemia (low blood sugar).
  • Ginkgo biloba. Concomitant use of this medicine with Brufen, increases the risk of bleeding.
  • Antibiotics, such as:
    • ciprofloxacin,
    • norfloxacin,
    • ofloxacin,
    • levofloxacin and others. Concomitant use of the Brufen with these medicines, increases the risk of convulsions.

Tell your doctor about all medications and herbal products you are taking.

Side effects

Brufen may cause following side effects:

  1. nausea,
  2. vomiting,
  3. diarrhea,
  4. constipation,
  5. abdominal pain,
  6. bleeding in the stomach,
  7. headache,
  8. dizziness,
  9. mood changes,
  10. photosensitivity (increased sensitivity to sunlight),
  11. decrease in the number of white blood cells (leukopenia),
  12. decrease in the number of platelets in the blood (thrombocytopenia),
  13. impaired hepatic function (pain in the upper right abdomen, loss of appetite, jaundice-yellowing of the skin and eyes),
  14. flu-like symptoms (fever, cough, sore throat),
  15. allergy and others.

Tell your doctor if you are experiencing any side effects.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.