Cefpodoxime - Side Effects | Use

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Cefpodoxime is a drug from the group of cephalosporins. Cefpodoxime is an antibiotic that it is used in the treatment of infections. Cefpodoxime has bactericidal effect and kills bacteria.

Cefpodoxime is used to treat infections of the upper respiratory tract (sinusitis, sore throat, tonsillitis, pneumonia, bacterial bronchitis) as well as in the treatment of skin infections and urinary tract infections.


Cefpodoxime should be avoided in patients who are allergic to Cefpodoxime or other similar medicines: ceftriaxone (Longacef), cefaclor, cefuroxime, cefepime, cefadroxil, ceftazidime, cephalexin, ampicillin, amoxicillin, penicillin, co-amoxiclav (Panklav) and others. If you are experiencing symptoms of an allergy such as: rash, itching, redness, swelling, difficulty breathing, contact physician immediately.

Cefpodoxime should be avoided in both, patients with renal failure and patients who have or have ever had intestinal infection caused by antibiotics (colitis). If you experience diarrhea, contact your doctor, because this may be a sign that intestinal infection has occured.

Cefpodoxime may affect the results of certain lab tests.

Use of Cefpodoxime during pregnancy and breastfeeding

According to the US Agency for Food and Drug Administration, Cefpodoxime belongs to the group B (FDA: Group B). This means that animal studies have shown that Cefpodoxime have no adverse effects on the fetus, but there are no studies on humans. Talk to your doctor about using Cefpodoxime during pregnancy.

Cefpodoxime passes into breast milk and may harm your baby. Avoid breastfeeding while using Cefpodoxime. Instead of breastfeeding your baby, you can give your baby formula milk.

How to use

Cefpodoxime is found in the form of tablets at doses of 100 mg and 200 mg and in the form of syrups, which are intended for use in children.

The dose depends on the type of infection:

Respiratory tract infections (bacterial bronchitis, pneumonia, tonsillitis, laryngitis): The usual dose is 100-200 mg twice a day (every 12 hours). Duration of therapy depends on the severity of the infection, and usually it lasts 7-10 days.

Sinuses infection (sinusitis): 200 mg twice a day.

Throat infections, urinary infections: 100 mg twice a day for 7-10 days.

Skin and soft tissue infections: 400 mg twice a day for one or two weeks.

Cefpodoxime tablets should be taken with a meal because the food improves efficacy of Cefpodoxime.

Cefpodoxime syrup can be taken regardless of food.

If you take more Cefpodoxime tablets than recommended by your doctor, following symptoms may occur: nausea, vomiting, diarrhea.

Use with other medicines (Interactions)

Cefpodoxime should be avoided in combination with the following medicines:

  • Water pills (diuretics), used in the treatment of high blood pressure, such as: furosemide, bumetanide, torasemide and others. Concomitant use of Cefpodoxime with these medications increases the risk of kidney damage.
  • Aminoglycosides, used in the treatment of bacterial infections, such as: gentamycin, amikacin, streptomycin and others. Concomitant use of these medicines with Cefpodoxime increases the risk of hearing loss and kidney damage.
  • Lithium, used to treat depression.
  • Antacids, medicines used for the stomach acid neutralization, to relieve heartburn, such as: magnesium carbonate, calcium carbonate, sodium hydrogen carbonate and others.
  • Medicines used to treat stomach and duodenal ulcers, such as: ranitidine (Ranisan), famotidine and others.
  • Probenecid, used in the treatment of gout.
  • Methotrexate, used to treat cancer and autoimmune diseases.
  • Hormonal preparations
  • Medicines used to treat thrombosis, such as: warfarin (Farin).

Tell your doctor about all medications and herbal medicines you are taking.

Side effects

Cefpodoxime may cause the following side effects: nausea, vomiting, diarrhea, abdominal pain, flatulence (bloating), intestinal infection (colitis), headache, dizziness, fainting, weakness, ringing in the ears, liver damage (jaundice-yellowing of the eyes and skin), kidney damage (difficulty urinating), anemia, decrease in the number of white blood cells (leucopenia), allergy and others.

Tell your doctor if you are experiencing any side effects.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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