Ciplox

Ciplox - Dosage | How to use

Category Fluoroquinolones

Ciplox contains an active substance called ciprofloxacin and belongs to fluoroquinolones (antibiotics). This medicine kills bacteria that have caused an infection. It is used to treat a number of bacterial infections (caused by bacteria susceptible to this antibiotic). It is used in the treatment of the following infections:

  • Respiratory tract infections (infections of the airways)
  • Urinary tract infection
  • Genital infection (infection of the genital tract in both men and women)
  • Skin and soft tissue infections
  • Eye infections.
  • Bone in joint infections.
  • Gastrointestinal tract infections.
  • Infections due to low leukocyte count (agranulocytosis)

Precautions

Ciplox must not be used in the following conditions:

  • In patients allergic to the active substance ciprofloxacin or other similar medications, such as:
    • ofloxacin (Visiren),
    • norfloxacin,
    • levofloxacin, and others. If you are experiencing symptoms of an allergy, such as:
      • itching of the skin,
      • swelling of the face,
      • swelling of the tongue and difficulty breathing contact your doctor immediately.
  • Patients taking tizanidine, a drug used to relax the muscles (muscle relaxant medication).
  • In patients with myasthenia gravis (autoimmune neuromuscular disease).
  • In patients who have or have ever had tendon damage. This medicine can cause tendon rupture (the tendon connects muscles to the bones), and it is necessary to immediately contact your doctor if you are experiencing pain in the tendons (or muscle) or you have swelling of the muscles. If you are experiencing these symptoms, discontinue use, rest the affected region and call your doctor. Tendon damage may occur several months after you stop using Ciplox.
  • In patients suffering from epilepsy or have had a stroke or other central nervous system disorders, since such patients are at greater risk for side effects when using this drug.
  • In patients with heart disease or in patients who are using drugs for treating heart disease, such as:
    • amiodarone,
    • quinidine,
    • ibutilide,
    • sotalol, and others.
  • In patients who have kidney or liver disease, it is necessary to adjust the dose of Ciplox.

It can cause a suicidal ideation especially in patients who already suffer from any psychiatric disease or patients who are taking this medicine for the first time. Immediately stop using the medicine if you are experiencing these symptoms.

This medicine can, like all other antibiotics cause diarrhea. Tell your doctor if diarrhea is persistent and bloody as this may be a sign that intestinal infection occurred (i.e. colitis).

Ciplox is excreted through the liver, and therefore may cause damage to this organ. If you are experiencing symptoms such as:

  1. jaundice (yellowing of the skin and eyes),
  2. dark urine,
  3. nausea,
  4. vomiting,
  5. loss of appetite,
  6. pain in the right upper abdomen and others, contact your doctor immediately as these symptoms may be sign of liver damage.

Ciplox can decrease the number of white blood cells (so-called agranulocytosis), which weaken your immune system. Due to a weakened immune system, your body will be more susceptible to numerous infections, because it will not be able to defend against microorganisms.

If you are experiencing flu-like symptoms, such as:

  1. fever,
  2. cough,
  3. sore throat,
  4. fatigue

contact your doctor immediately, because it indicates that agranulocytosis have occurred.

It is necessary to avoid increased exposure to sunlight, because this drug can cause increased sensitivity to sunlight (also known as photosensitivity). Make sure you cover as much of the skin when you get out.

Use of Ciplox during pregnancy and breastfeeding

Ciplox should be avoided during pregnancy unless the benefit to the mother outweighs the risk to the child. Consult your doctor about this medicine safety during pregnancy.

Avoid breastfeeding while using this medicine. This medication passes into breast milk and may harm your baby.

How to use

Dosage in adults:

Condition (Indication) Dose
Acute uncomplicated cystitis in women 250 mg or 500 mg twice a day (every 12 hours) for three days.
Complicated cystitis and complicated pyelonephritis 500 mg twice a day (every 12 hours), for one week.
Chronic prostatitis 500 mg twice a day (every 12 hours) for 4 weeks (28 days).
Respiratory tract infections 500 mg (for severe infections dose can be increased to 750 mg) twice a day during 7 to 14 days.
Gonorrhea 500 mg once a day, for just one day.
Antibiotic prophylaxis in surgery 750 mg, an hour before the surgery.
Gastrointestinal tract infections 500 mg twice a day (every 12 hours) for 3-7 days.
Bone and joint infections 500 or 750 mg twice a day (every 12 hours), up to 3 months.

Use of Cifran in children is not recommended! If necessary to use this medication in children, then the dose should be calculated based on the child's body weight. The usual dose is 20 mg / kg of body weight.

Take your tablet whole, with a glass of water. Do not crush or chew the tablet as this may affect its activity. Avoid dairy products while using this medicine, because milk and dairy products may decrease the level of Cifran in the blood due to the high calcium content. If you use them, make sure that at least 3 hours passed after the last use of Ciplox. It is best to take this medicine immediately after meals to reduce the risk of stomach problems.

This drug also exists in the form of eye drops and it is used to treat eye infections caused by susceptible bacteria.

Use with other medicines (Interactions)

Ciplox should be avoided in combination with the following drugs:

  • Warfarin, a drug used in the treatment of blood clotting disorders (blood thinner). Concomitant use of Ciplox with this drug increases the risk of bleeding.
  • Sildenafil (Viagra), a drug used for erectile dysfunction. Ciplox increases the level of this drug in the blood, increasing the risk of side effects.
  • Pentoxifylline (Trental, Damaton), a drug used to treat peripheral circulation disorders. Ciplox can increase the level of this drug in the blood, increasing the risk of side effects.
  • Phenytoin, a drug used in the treatment of epilepsy.
  • Methotrexate, a drug used in the treatment of cancer.
  • Cyclosporin, a drug used in the treatment of autoimmune diseases.
  • Probenecid, a drug used in the treatment of gout.
  • Drugs used in the treatment of diabetes.
  • Drugs used in the treatment of cardiac arrhythmias (irregular heart beat), such as:
    • amiodarone,
    • quinidine,
    • disopyramide,
    • ibutilide,
    • sotalol, and others.
  • Drugs used in the treatment of depression and other psychiatric diseases, such as:
    • moclobemide,
    • phenelzine,
    • isocarboxazid,
    • sertraline,
    • paroxetine,
    • fluoxetine,
    • fluvoxamine,
    • duloxetine,
    • citalopram,
    • escitalopram,
    • imipramine,
    • promazine and others.
  • Omeprazole (Omeprol), a drug used in the treatment of gastric and duodenal ulcers and Helicobacter pylori eradication. This medicine reduces the level of Ciplox in the blood, thus reducing the effectiveness of this drug.
  • Preparations of calcium, magnesium or iron (including effervescent tablets). These drugs reduce the effect of Ciplox.
  • Antacids, drugs that neutralize stomach acid. These drugs decrease the levels of Ciplox in the blood, which can lead to the lack of efficacy. If you must take antacid, take it at least two hours before or 4 hours after taking Ciplox.

Tell your doctor about all medications and herbal products you are taking.

Side effects

Ciplox can cause tendon rupture (the tendon connects muscle to the bone)! Immediately contact your doctor if you are experiencing pain in the muscles or swelling of the muscle!

It can cause diarrhea, which may be accompanied by blood in the stool! Immediately contact your doctor if you are experiencing this symptom because it may be a sign that intestinal infection occurred. This infection can be dangerous!

Ciplox can, although very rarely, cause Stevens-Johnson syndrome (a severe skin disease, manifested by blisters on the skin that are rapidly expanding). Tell your doctor immediately if you are experiencing any skin changes.

This medicine sometimes can cause suicidal ideation, especially in patients who are taking this medicine for first time. It should be noted to the patient's family, that they need to immediately inform doctor if they notice behavior changes in the patient.

This drug may rarely cause agranulocytosis (very low number of white blood cells), which reduces your ability to fight against infections. Immediately contact your doctor if you are experiencing flu-like symptoms.

It may also cause the following side effects:

  1. nausea,
  2. vomiting,
  3. abdominal pain,
  4. flatulence,
  5. loss of appetite,
  6. headache,
  7. dizziness,
  8. liver damage (jaundice, loss of appetite, itching, nausea, vomiting, pain in the right upper abdomen and dark urine),
  9. mood swings,
  10. nightmares,
  11. hallucinations,
  12. photosensitivity (increased sensitivity to sunlight),
  13. rapid heartbeat,
  14. muscle pain,
  15. joint pain,
  16. excessive sweating,
  17. allergy and others.

Tell your doctor if you are experiencing any side effects.