Clarinase - Dose | Effects | How to use

This article was medically reviewed by M.Pharm, Marko Tanaskovic on Thu, 27 Dec 2018. To read more about an author, click here.

Clarinase is a medicine that contains two active substances loratadine (at a dose of 5 mg) and pseudoephedrine (at a dose of 120 mg). It belongs to a group of medicines called nasal decongestants for systemic use. Loratadine belongs to H1 antihistamines while pseudoephedrine belongs to a group of medicines known as decongestants. It is used to reduce symptoms of allergic rhinitis (hay fever) accompanied by nasal congestion (stuffy nose). Symptoms of allergic rhinitis include: runny nose, itchy nose, sneezing, watery, itchy eyes and nasal congestion.


Clarinase should be avoided in the following conditions:

  • In patients allergic to any of the active substances (pseudoephedrine or loratadine) or other similar drugs.
  • Thyroid disease.
  • In patients with angle-closure glaucoma (increased eye pressure).
  • In patients with heart disease. If you are experiencing high blood pressure (hypertension), rapid heart rate (tachycardia) or feelings of having rapid and pounding heart (palpitations), contact your doctor immediately.
  • Patients who have suffered a stroke.
  • In patients with breathing problems.
  • In patients with bladder disorders.

If you are using medicines to treat depression (known as MAO inhibitors), such as:

  • moclobemide,
  • selegiline (also used to treat Parkinson's disease),
  • isocarboxazid,
  • phenelzine and others, then you should avoid use of this drug. Concomitant use of Clarinase with these drugs may cause serious side effects! You should wait at least two weeks after stopping MAO inhibitors, before you start taking this medicine.

This drug should be avoided in patients above the age of 65, due to an increased risk of side effects.

Clarinase can be used only with extra precautions in the following conditions:

  • In patients with liver or kidney diseases.
  • In patients with gastric or duodenal ulcer.
  • In patients suffering from diabetes mellitus.

Since that Clarinase contains pseudoephedrine (a sympathomimetic agent) there is a risk for drug abuse.

If you are planning to do allergy testing in the near future (within two weeks), you should stop taking this medicine before you get an allergy test, because this medicine contains loratadine (anti- allergy medicine).

Athletes should know that this drug may cause a positive doping test because it contains pseudoephedrine.

Use of Clarinase during pregnancy and breastfeeding

It should be avoided during pregnancy and breastfeeding!

This drug passes into breast milk and may harm your baby.

How to use

Usual dose is one Clarinase tablet twice a day. Take your tablet with a glass of water during the meal.

It should be avoided in patients under the age of 12 and those above the age of 65.

It should usually not be taken for more than 10 consecutive days.

Use with other medicines (Interactions)

Clarinase should be avoided in combination with the following drugs:

  • MAO inhibitors, used to treat depression, such as:
    • moclobemide,
    • selegiline (it can be also used in the treatment of Parkinson's disease),
    • isocarboxazid,
    • linezolid, and others. Concomitant use of these drugs with Clarinase can cause serious side effects.
  • Drugs used to treat migraines, called ergot alkaloids, such as:
    • ergotamine,
    • dihydroergotamine and methylergometrine (used to stop bleeding). Concomitant use with these drugs can cause high blood pressure (hypertension).
  • Drugs known as dopamine agonists, such as:
    • bromocriptine and cabergoline. Concomitant use of these medications with Clarinase increases the risk of hypertension.
  • Other medicines used to treat nasal congestion (stuffy nose), including nose drops. Concomitant use of these medications with Clarinase can cause high blood pressure.
  • Medications used for weight loss.
  • Drugs used to treat high blood pressure or other heart diseases.
  • Pergolide, a drug used in the treatment of Parkinson's disease.
  • Antacids, drugs used to neutralize stomach acid. These drugs may increase the levels of Clarinase in the blood and cause side effects.

Tell your doctor about all medications and herbal products you are taking.

Side effects

Clarinase may cause the following side effects:

  1. high blood pressure (hypertension),
  2. rapid heart rate (tachycardia),
  3. feelings of having rapid and pounding heart (palpitations),
  4. headache,
  5. dizziness,
  6. ringing in the ears,
  7. increased sweating,
  8. mood swings,
  9. depression,
  10. anxiety,
  11. nausea,
  12. vomiting,
  13. constipation,
  14. dry mouth,
  15. fatigue,
  16. shortness of breath,
  17. cough,
  18. hair loss (alopecia),
  19. allergy and others.

Tell your doctor if you are experiencing any side effects.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.