Clomid - Use | Dose | Side Effects

Clomid contains clomiphene and is used for the treatment of fertility in men and women. In women it works by stimulating ovulation1, while in men it works by increasing the levels of FSH and thus increase sperm count.2 It is particularly effective in men who are overweight and have hypogonadism.3

Safety precautions

Clomid can cause a slight increase in liver enzymes in the blood, therefore it should not be used in patients who have serious liver impairment.

No major side effects have been reported. The studies mostly reported side effects, such as: excessive hair growth, premature ejaculation and facial acne.

Probably the most significant and most serious side effect that can occur due to the Clomid use is vision loss that occurs due to ischemic optic neuropathy.4 Namely, Clomid may reduce the blood flow through the ciliary artery that supplies the eye with blood, and this leads to vision loss.

If you notice any vision changes/disturbances, tell your doctor immediately.

Clomid has an impact on the thyroid function5, and patients who have problems with thyroid gland must consult a doctor before they start taking Clomid.

Clomid can't be used in patients who have a tumor of the pituitary gland, a tumor of the adrenal gland or a tumor of the thyroid gland.

It should not be applied in women who are already pregnant.

Dosage

Dosage in women

Clomid is taken on the 5th day of menstruation and the duration of treatment is five days. The usual dosage is one tablet per day. The maximum daily dose is 250 mg per day. Ovulation occurs within 5 to 10 days from the treatment initiation and your gynecologist will likely follow the process of ovulation on an ultrasound to determine whether this medicine causes ovulation or not.

If ovulation does not occur after first month, the dose can be increased for another 50 mg in the next month. If ovulation does not occur after three months of treatment, then you should consider another form of therapy.

Dosage in men

The usual dose is 25-50 mg daily for 25 days. After the 25th day, you should have a 5-day break. After that the treatment cycle can be repeated.

Interactions

Clomid does not interact with a large number of drugs. Up to now, only two drugs are known to interact with Clomid, as follows:

  • Bexarotene (anti-cancer drug). Concomitant use of Clomid with this drug increases the risk of pancreatitis.
  • Ospemifene (a drug used to relieve pain during sexual intercourse). Co-administration of these two drugs increases the risk of thrombus formation.

Adverse effects

Clomid is associated with the following side effects:

  • Enlargement of ovary
  • Flushing
  • Pain in the lower abdomen
  • The feeling of discomfort in the stomach
  • Skin reactions
  • Increase in body weight
  • Vision problems
  • Loss of vision
  • Heavy vaginal bleeding

References

  1. NCBI link 1
  2. NCBI link 2
  3. NCBI link 3
  4. NCBI link 4
  5. NCBI link 5