Cyproterone - Use | Dosage | Effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on Thu, 27 Dec 2018. To read more about an author, click here.

Cyproterone belongs to a group of medicines called antiandrogens. It can be used in both men and women.

In men, this medicine is used to reduce the drive in sexual deviations and to treat prostate cancer.

In woman, it is used to treat hirsuitism (increased hair growth in women on the cheeks, chin, breasts) and hormone-related alopecia (hair loss).


It cannot be used in the following conditions:

  • In patients with liver disorders. Tell your doctor if you have or have ever had jaundice.
  • Patients who are allergic to Cyproterone or other similar medications
  • Patients with bilirubin metabolism disorders (ie, Dubin-Johnson syndrome)
  • In patients who have or have ever had liver tumors
  • Cyproterone cannot be used during pregnancy and breast-feeding
  • In patients with sickle cell anemia
  • Patients with depression
  • In patients with diabetes followed with damaged blood vessels
  • If you have had herpes during pregnancy

It can cause liver damage (sometimes have a fatal outcome), so it is very important to contact your doctor if signs of liver damage occur. Signs of liver damage include: dark urine, jaundice (yellowing of the skin and eyes), loss of appetite and others. The increased risk for liver damage is observed at higher dose of tablet.

Cyproterone may cause the brain tumor (meningioma). If a meningioma occurs, you should immediately stop using this drug.

Patients with diabetes should reduce the dose of medicines used to treat diabetes.

It reduces sperm count and may lead to temporary infertility. Few months after you stop taking this medicine, sperm count returns to normal.

Use during pregnancy and brest-feeding

Cyproterone should not be used during pregnancy and breast-feeding because it may harm your baby!

Use and Dose


The usual dose of Cyproterone in men for the reduction of drive in sexual deviations is 50 mg twice daily (every 12 hours). Dose must be determined by your doctor! Dose can be increased gradually, as necessary, until the desired effect is achieved. You will need to take this drug a longer period of time to achieve desired effect.

The usual dose in men for the prostate tumor treatment is 100 mg, 2-3 times a day (every 8 or 12 hours).


In women, Cyproterone should be used on the first day of the menstrual cycle. The usual dose is 50 mg twice daily (every 12 hours) until the 10th day of the cycle. Usually you will need to use Cyproterone concomitant with other estrogen preparations, from the first to the 21-st day of the menstrual cycle in order to normalize the cycle. After 21 days, do not use these medicines for the next 7 days. Bleeding occurs during this pause. After 7 days pause, repeat the use, regardless of whether you still have bleeding or not.

In postmenopausal women this drug need to be used at a dose of 50 mg once a day for 21 days.

It is very important to take Cyproterone each day at the same time and try not to forget to take a tablets!

Cyproterone tablets cannot be used in children.

Use with other medicines (Interactions)

Cyproterone cannot be used in combination with the following medicines:

  • Medicines used for diabetes treatment, such as:
    • metformin (Gluformin),
    • insulin and others. Cyproterone may decrease the efficacy of these medicines.
  • Statins, medicines used to treat high cholesterol, such as:
    • simvastatin (Cholipam),
    • fluvastatin,
    • lovastatin,
    • rosuvastatin,
    • pravastatin,
    • atorvastatin. Cyproterone may increase the effect of these medicines and increase the risk of rhabdomyolysis (severe breakdown of muscle tissue).
  • Red rice. Red rice contains a substance that is similar to lovastatin and for the same reason as with statins, red rice cannot be used in combination with Cyproterone.
  • Medicines used to treat fungal and bacterial infections, such as:
    • erythromycin,
    • clarithromycin,
    • rifampicin,
    • itraconazole,
    • ketoconazole and others.

Tell your doctor about all medications and herbal preparations you are taking.

Side effects

Cyproterone can cause the following side effects:

  1. shortness of breath,
  2. reduction in sperm count,
  3. decreased libido,
  4. mood disorders (depression, anxiety),
  5. liver damage (jaundice, dark urine, loss of appetite),
  6. gynecomastia (breast enlargement in men),
  7. changes in body weight,
  8. osteoporosis (bone damage),
  9. allergy and others.

Tell your doctor if you experience any side effect.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.