Deptran - Dosage | Interactions | Effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Deptran is a drug that contains doxepin as the active s ubstance and belongs to the group of tricyclic antidepressants. It exhibits an antianxiety, antidepressant, anti-ulcer and sedative effects. It is used to treat depression, anxiety and insomnia.


Deptran must not be used in the following conditions:

  • Narrow-angle glaucoma
  • Urinary retention
  • Co-administration with a monoamine oxidase inhibitors (MAOI), such as:
    • tranylcypromine
    • phenelzine
    • moclobemide
    • selegiline
    • linezolid


Deptran must be applied very cautiously in patients with a positive anamnesis of suicidal thoughts. This drug increases the risk of suicidal thoughts, especially among young people (less than 24 years).

One part of the drug is excreted by the kidney and the other part by the liver, therefore it must be very carefully applied in patients with impaired renal or liver function.

Deptran, pregnancy and breastfeeding

AU TGA classifies this drug to a group C - studies in animals have shown that it may interfere with the transmission of neuroamines in central nervous system which may cause side effects. There are data that indicate the possible occurrence of malformations in the fetus if the drug is administered during pregnancy in higher doses. For this reason, this drug should not be used during pregnancy unless clearly needed.

Shortness of breath may occur in infants whose mothers took this medicine during lactation, which is why its use is contraindicated during breastfeeding.


The usual initial dose is 75 mg daily, while the maintenance dose is in the range from 75 mg to 150 mg per day. The maximum daily dose is 150 mg. Take your tablet half an hour before bedtime.

Take a pill three hours after your last meal, because food can affect the activity and efficacy of this drug.

Your doctor will determine which dosage of Deptran you need.


Deptran should not be administered concurrently with the following drugs:

  • Sympathomimetics - drugs that act as adrenaline (e.g., ephedrine and phenylephrine, including nasal drops). Concomitant use can cause severe hypertension.
  • Efavirenz. Concomitant use increases the risk of arrhythmia.
  • Moxifloxacin, norfloxacin, ciprofloxacin and ofloxacin. Concomitant use increases the risk of QT prolongation causing serious arrhythmias.
  • Bupropion. Concomitant use increases the risk of seizures.
  • Antiarrhythmics (quinidine, sotalol and amiodarone). Concomitant use with these drugs increases the risk of arrhythmia.
  • Tramadol. Concomitant use increases the risk of seizures.
  • Zonisamide. Concomitant use increases the risk of thermal shock.

Concomitant use with following drugs increases the risk of serotonin syndrome:

  • Tryptophan
  • Muscle relaxants (e.g. cyclobenzaprine)
  • Other tricyclic antidepressants
  • Selective serotonin reuptake inhibitors
  • MAOIs
  • Anxiolytics (e.g. buspirone)
  • Ondansetron

Adverse reactions

Deptran may cause the following adverse reactions:

  • Gastrointestinal adverse reactions (presence of blood in the stool, and consequently black stools, nausea and vomiting)
  • Seizures
  • Sore throat
  • Drooling
  • Numbness of limbs
  • Psychomotor agitation
  • Irritability
  • Suicidal ideation
  • Shivering
  • Hallucinations
  • Difficulty breathing
  • Slurred speech
  • Increased appetite and consequent rapid increase in body weight
  • Loss of hearing
  • The feeling of tightness in the chest
  • Nervousness
  • Insomnia
  • Unintentional muscle movements
  • Snoring
  • Allergy

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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