Diprosone - How to apply | Interactions

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Diprosone is a drug that exists in semisolid dosage forms (creams, ointments and lotions) and contains betamethasone as an active substance. It belongs to a group of corticosteroids intended for topical use. When applied to the skin, it exerts immunosuppressive, anti-proliferative and anti-inflammatory effects.


It is used to treat the following skin diseases:

  • Various types of dermatitis (contact dermatitis, diaper dermatitis, atopic dermatitis, seborrheic dermatitis, neurodermatitis and photodermatitis)
  • Psoriasis
  • Eczema
  • Itching in the genital area of unknown cause
  • Excessive growth of scars after skin injury (i.e. keloids)
  • Chronic recurrent dermatoses (such as lichen ruber planus)
  • Localized accumulation of mucopolysaccharides in the front side of the lower leg (i.e. pretibial myxedema). This disease occurs in 5% of patients who have Graves' disease.
  • Vitiligo - an autoimmune skin disease characterized by the destruction of skin pigment cells
  • Intertrigo - a skin disease characterized by redness on the skin areas that rub against each other.

Myers JB et al have shown that this Diprosone cream is effective in the treatment of pre-pubertal labial adhesion.


Diprosone should not be used in patients who are allergic to any of the corticosteroid drug.

It should be avoided in patients who have active viral, fungal or bacterial infections, as its active substance - betamethasone, exerts immunosuppressive activity and weaken your immune system so you can't fight infections easily.

Diprosone is contraindicated in children under the age of 1.

Its use for the treatment of acne is not recommended.

In some situations, the pediatrician may recommend using this preparation to treat rashes in babies younger than 1 year, but the treatment should not last longer than one week.

Its absorption through the skin into the blood stream is significantly increased if used under the diapers or under the bandages. Increased absorption may lead to systemic side effects. Systemic side effects include:

  • Intracranial hypertension
  • Growth retardation
  • Glaucoma and vision loss
  • High blood sugar
  • The presence of glucose in the urine
  • Iatrogenic Cushing's syndrome

The risk of systemic side effects is higher in the following situations:

  • In children (because their skin is more permeable than an adult's and their liver is less able to metabolize the drug quickly and adequately)
  • In patients who apply this medicine to thinner areas of the skin
  • In patients who apply large amounts of this preparation
  • In patients who apply this preparation over large areas of the skin
  • In patients who apply this medicine frequently or for prolonged periods of time
  • In patients who have liver or kidney diseases

Bear in mind that applying this preparation on the facial skin may cause rosacea.

Diprosone, pregnancy and breastfeeding

Use of this drug during pregnancy should be avoided since there is a risk of absorption and manifestation of systemic effects. But, if its use during pregnancy is necessary, then it should be used only over a small area of the skin and the treatment should last as short as possible.

Mothers who use this medication should not breastfeed children.

How to apply

A thin layer of Diprosone cream or ointment should be applied twice a day to the affected areas of the skin and rubbed in gently.

Diprosone cream is recommended for the treatment of acute skin conditions while Diprosone ointment is recommended for the treatment of chronic skin conditions.

The lotion is mainly used for the treatment of scalp psoriasis. Apply a few drops to the affected areas of the skin and gently rub into the skin. Always wash your hands after applying this preparation.


Diprosone is topical preparation, so it does not enter into clinically significant interactions with other drugs.

Side effects

Diprosone may cause the following side effects:

  • Cutaneous atrophy
  • Epidermal atrophy
  • Itching
  • Skin burning sensation
  • Redness of the skin
  • Skin rash
  • Stretch marks
  • Steroid purpura
  • Hypothalamic-pituitary-adrenal axis suppression
  • Iatrogenic Cushing's syndrome
  • Growth retardation in children
  • Hyperglycemia
  • Glycosuria
  • Alopecia
  • Dry skin
  • Acne
  • Lightening of skin color
  • Skin infections
  • Allergic reactions


  1. NCBI link 1
  2. NCBI link 2

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