Dormicum - Benzodiazepine | Use | Dose

This article was medically reviewed by M.Pharm, Marko Tanaskovic on Thu, 27 Dec 2018. To read more about an author, click here.

Dormicum is a medicine that contains an active substance called midazolam. It belongs to a group of medicines called benzodiazepines. It is used to treat insomnia or to prepare patient for surgery.


If you are experiencing breathing problems (shortness of breath, breathing interruption, slowed breathing), contact your doctor. This medicine can cause respiratory arrest and death!

Dormicum should be avoided in the following conditions:

  • In patients who are allergic to the active substance midazolam or other similar medications, such as:
    • alprazolam,
    • diazepam,
    • lorazepam,
    • bromazepam, and others.
  • Patients with myasthenia gravis (autoimmune neuromuscular disorder).
  • In patients with hepatic impairment.
  • In patients with respiratory disorders.
  • In patients with sleep apnea (pauses in breathing during sleep).

This medicine should not be used in combination with alcoholic beverages, due to an increased risk of side effects.

After discontinuation of Dormicum, a "rebound insomnia" may occur (characterized by severe insomnia, even more severe than before you start taking this medicine). This effect is short lived and usually does not last more than a few days. "Rebound insomnia" is usually accompanied by mood changes and agitation. In order to avoid this side effect, it is recommended to gradually reduce the dose before complete abolition of the medicine.

Example: If you are taking 15 mg per day, it is first necessary to reduce the dose to 7.5 mg per day during 5-7 days, and after that you can completely stop taking this medicine.

Consult your doctor before stopping this medicine.

This medicine may cause anterograde amnesia (you cannot remember the events experienced while under the influence of this medicine). Therefore, you should take this medicine immediately before bedtime.

This medicine may cause following side effects:

  • hallucinations,
  • aggressiveness,
  • restlessness,
  • irritability,
  • nightmares and others. If you are experiencing any of these symptoms, contact your doctor immediately. These symptoms are more common in patients above the age of 65.

This medicine should be used with extra precautions in patients who have heart diseases.

This medicine can cause dependence (addiction), especially if taken regularly over a long period of time in large doses.

Dose should be gradually reduced in order to avoid so-called "withdrawal syndrome". Symptoms of "withdrawal syndrome" include:

  1. headache,
  2. restlessness,
  3. irritability,
  4. anxiety,
  5. hypersensitivity to sound,
  6. hallucinations,
  7. convulsions and others. Your doctor will explain you how to decrease the dose gradually.

Use of Dormicum during pregnancy and breastfeeding

Dormicum should not be used during pregnancy because there is not enough data on Dormicum use during pregnancy. It should not be used in the last three months of pregnancy (especially in large doses), because this medicine can cause shortness of breath and low body temperature in newborns.

Dormicum passes into breast milk, therefore breastfeeding should be avoided while using this medicine.

How to use

The usual dose is 7.5 mg once a day, immediately before bedtime. If necessary, the dose may be increased to 15 mg once a day, immediately before bedtime. This medicine should be taken immediately before bedtime, in order to avoid anterograde amnesia.

Swallow the tablet whole with a glass of water.

Dormicum is not recommended for use at doses greater than 7.5 mg per day in patients above the age of 65.

It can be used in patients under the age of 18, only in rare cases. In such cases, the dose should be calculated according to body mass. Usual dose is 0.2 mg / kg of body weight.

Example: If your child weighs 40 kg, then dose should be calculated as follows:

40 kg x 0.2 mg / kg = 8 mg per day.

This is just an example. Your doctor will prescribe dosing schedule that is best for you. Do not take this medicine on your own, without your doctor's advice.

This medicine should not be used for more than a month, because prolonged use increases the risk of addiction.

Use with other medicines (Interactions)

Dormicum should be avoided in combination with the following medicines:

  • Antibiotics, medicines used in the treatment of bacterial infections, such as:
    • erythromycin,
    • clarithromycin,
    • roxithromycin and telithromycin. These medicines can increase the blood levels of Dormicum, increasing the risk of side effects.
  • Medicines used to treat fungal infections, such as:
    • fluconazole and itraconazole. These medicines can increase the blood levels of Dormicum, increasing the risk of side effects.
  • Medicines used to treat heartburn and gastric ulcers, such as: ranitidine.
  • Medicines used in the treatment of anxiety, depression and social phobia, such as:
    • fluvoxamine,
    • fluoxetine,
    • paroxetine and others.
  • Medicines used in the treatment of AIDS (HIV).
  • Opioid analgesics and antitussives, such as:
    • morphine,
    • codeine.
  • Antidepressants, medicines used in the treatment of depression, such as:
    • amitriptyline,
    • nortriptyline,
    • imipramine,
    • desipramine,
    • trazodone, and others.
  • Medicines used in the treatment of heart diseases, such as:
    • verapamil,
    • diltiazem.
  • Medicines used to treat epilepsy, such as:
    • carbamazepine,
    • phenobarbital,
    • phenytoin, and others.
  • St. John's Wort and Kava

Tell your doctor about all medications and herbal products you are taking.

Side effects

Dormicum may cause the following side effects:

  1. nausea,
  2. vomiting,
  3. constipation,
  4. breathing problems (shortness of breath, slowed breathing, breathing interruption),
  5. heart failure,
  6. low blood pressure (hypotension),
  7. headache,
  8. dizziness,
  9. drowsiness,
  10. muscle weakness,
  11. restlessness,
  12. irritability,
  13. hallucinations,
  14. convulsions,
  15. mood changes,
  16. aggression,
  17. nightmares,
  18. dependence,
  19. allergy and others.

If you are experiencing any of abovementioned side effects, contact your doctor immediately.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.