Duodart

Duodart - Use | Dose | Side Effects

Duodart is a medicine that contains two active substances: dutasteride (0.5 mg), and tamsulosin (0.4 mg).

It belongs to a group of medicines called alpha-adrenergic antagonists (also called alpha blockers). Dutasteride blocks the action of 5-alpha reductase enzymes. These enzymes convert testosterone into 5-alpha-dihydrotestosterone (DHT), which is responsible for prostate hypertrophy. Blocking this enzyme prevents the prostate from further growing. Tamsulosin blocks alpha receptors in the prostate and bladder, relax smooth muscles of the prostate and bladder, and facilitates urination.

Because of such effects, it is used in the treatment of benign prostate enlargement (Benign Prostatic Hyperplasia-BHP) and for the prevention of urinary retention.

Precautions

Duodart should be avoided in the following conditions:

  • In patients with hepatic impairment.
  • Patients with hypotension (low blood pressure).
  • In women and children.
  • In patients who are allergic to dutasteride or tamsulosin.

This medicine should be used only with extra precautions in patients with renal impairment, because there is not enough data on its safety in such patients.

Keep in mind that benign prostate enlargement and prostate cancer have similar symptoms. Therefore, your doctor will want you to have certain diagnostic tests, before you start treatment in order to rule out a diagnosis of prostate cancer.

It is recommended PSA (prostate specific antigen) testing and digital rectal examination. Doctors need to know that the concentration of PSA in the blood can be lower in patients taking Duodart.

If you are having cataract surgery, tell your doctor that you are taking this medicine.

This medicine may cause orthostatic hypotension - a form of low blood pressure-hypotension that happens when you get up quickly from a lying or sitting position and it accompanied with dizziness or loss of consciousness. If you are experiencing these symptoms, you should lie down and elevate your legs or sit down and put your head between your knees.

This medicine can be absorbed through the skin, therefore avoid contact with powder that spills out from damaged capsules. If you, however, have come in contact with powder from damaged capsules, immediately wash affected area thoroughly with soap and water.

Use of Duodart during pregnancy and breastfeeding

This medicine can be used only in men, and should be avoided in women.

This medicine lower sperm count, decreases sperm motility and sperm volume, thus reduce the chances of pregnancy.

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How to use

Duodart should be taken half an hour after breakfast, at the same time every day. The usual dosage is one Duoadart capsule per day.

Swallow the capsules whole with a glass of water. Do not crush or open the capsule as the powder from capsules may irritate the mucous membranes in the mouth and throat.

Use with other medicines (Interactions)

Duodart should be avoided in combination with the following medicines:

  • Medicines used in the treatment of HIV infection (AIDS), such as:
    • ritonavir,
    • indinavir, and others. Concomitant use of Duodart with these medicine may increase the level of Duodart in the blood, thereby increasing the risk of side effects.
  • Medicines used in the treatment of fungal infections, such as:
    • itraconazole,
    • fluconazole,
    • ketoconazole and others. These medicines may increase level of Duodart in the blood, increasing the risk of side effects.
  • Medicines used in the treatment of depression, such as: nafazodon. Concomitant use of Duodart with this medicine may increase the level of Duodart in the blood, increasing the risk of side effects.
  • Other alpha-blockers, such as:
    • prazosin,
    • teraozosin,
    • doxazosin,
    • alfuzosin, and others. Concomitant use of Duodart with these medicine increase the risk of hypotension.
  • Medicines used to treat high blood pressure or other cardiac diseases (the so-called calcium channel blockers), such as:
    • verapamil,
    • diltiazem. Concomitant use of Duodart with these medicine increase the risk of hypotension.

Tell your doctor about all medications and herbal products you are taking.

Side effects

Duodart may cause the following side effects:

  1. nausea,
  2. vomiting,
  3. diarrhea,
  4. constipation,
  5. decrease in sexual desire (decreased libido),
  6. impotence (the inability to achieve and maintain an erection),
  7. abnormal ejaculation,
  8. enlarged breasts in men (gynecomastia),
  9. orthostatic hypotension (low blood pressure when you get up quickly from a lying position),
  10. fatigue,
  11. dizziness,
  12. severe headache,
  13. runny nose,
  14. allergy and others.

Tell your doctor if you are experiencing any side effects.

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Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.