Elonva - Dosage | Side Effects | Use
Elonva is a medicine that belongs to the group of gonadotropin hormones, which play a very important role in fertility. The active substance of the Elonva is called corifollitropin alfa, and it is actually a hormone known as FSH (follicle stimulating hormone). FSH, as its name implies, stimulates the development of follicles in ovaries that can be fertilized, which increases the chance of pregnancy.
Elonva is used in women who are treated for infertility.
When Elonva should not be used?
Elonva is contraindicated in the following cases:
- In women who have ovarian, uterine or breast cancer
- In women who have vaginal bleeding of unknown cause
- In women who have primary ovarian insufficiency
- In women who have or have had ovarian hyperstimulation syndrome
- In women who have fibroids
The use of Elonva injection in women can lead to the occurrence of ovarian hyperstimulation syndrome - a condition in which egg cells growing in the ovaries become larger than normal. Therefore, the following symptoms occur:
- Very severe pain in the lower abdomen
- Severe nausea
Due to the possible occurrence of ovarian hyperstimulation, Elonva should not be used more than once during one menstrual cycle.
Tell your doctor if you have or have had polycystic ovary syndrome.
The use of the Elonva drug can lead to the formation of thrombi (blood clots) in the blood vessels. These clots can detach from the blood vessel and travel to the heart, lungs or brain which leads to blockages of blood vessels and thus lead to serious consequences (heart attack, pulmonary embolism or stroke). Because of that possible side effect, Elonva should not be used or should only be used with great caution in women who have had thrombosis or have a family history of thrombosis. The risk of thrombosis is greater in women who smoke.
Treatment with this drug may cause an occurrence of ectopic pregnancy. Women who become pregnant during treatment with this drug have a higher chance of having twins.
Elonva and its use with food and drugs
Since this is a new drug, there is not enough research on its interactions with other drugs or food. Therefore, it is necessary to inform your doctor about any medicines you are taking.
How should you apply Elonva?
Elonva is used in women who are being treated for infertility, usually within the medically assisted fertilization procedure such as in vitro fertilization (IVF). Elonva is used in combination with drugs that prevent premature ovulation (Ganirelix, Abarelix and Cetrorelix), which is given to women five days after application of Elonva. These drugs must not be administered on the same day as this can lead to excessive stimulation of the ovaries.
Dose depends primarily on your weight. Women who weigh less than 130 lb. (60 kg) should receive 100 micrograms in the first few days of menstrual cycle.
Women who weigh more than 130 lb. (60 kg) should receive 150 micrograms in the first few days of menstrual cycle.
Elonva is applied under the skin (subcutaneously) below the navel. Usually the injections are given by trained medical staff, but your doctor can train you to apply this injection all by yourself. However, if your doctor does not explain how to apply the Elonva injection, you should not try this at home.
A week after the administration of this drug, your doctor can recommend that you continue the treatment with another gonadotropin hormone. This treatment should last for several days until the doctor confirms in the ultrasound examination that you have sufficient number of eggs. Then the doctor interrupts the treatment and gives you the HCG (human chorionic gonadotropin) to stimulate the maturation of egg cells, which are then removed 36 hours later.
Elonva adverse effects
Possible adverse effects of this drug include:
- Pain and discomfort in the pelvis
- Breast problems (breast tenderness)
- Ovarian hyperstimulation syndrome
- Ovarian torsion - ovarian rotation that leads to the pain in the lower abdomen
The most serious side effect of this drug is certainly ovarian hyperstimulation syndrome, which can be a serious medical condition because it can cause blood clots and various complications. The risk of hyperstimulation can be reduced if the doctor regularly monitors the number of egg cells. One of the first symptoms of ovarian hyperstimulation is pain in the lower abdomen.