Emanera - Precautions | Dose | Side Effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Emenera is a drug produced in Slovenia and as an active substance contains esomeprazole. Esomeprazole is a member of the group of drugs known as proton pump inhibitors. It can be found in two dosage forms - 20 mg and 40 mg capsules.

From a chemical point of view, this drug is a weak base and inhibits acid secretion in the stomach. It is therefore useful in the treatment of heartburn, ulcers and esophageal reflux. It exhibits rapid effects (within one hour).

When you should take precautions

Since this drug may mask the symptoms of cancer in the digestive tract, it can postpone the diagnosis of cancer. It is necessary to exclude cancer as a possible diagnosis prior to starting therapy. Tell your doctor if you feel symptoms, such as:

  • Dysphagia (difficulty swallowing)
  • Hematemesis (vomiting blood)
  • Melena (blood in stool)
  • Unintentional weight loss

If this medication is used for long-term treatment, it is necessary to periodically have a medical check-up (every three months).

Long-term use of this drug and other proton pump inhibitors may lead to a deficiency of vitamin B12, vitamin C, calcium, magnesium and iron. Although these deficiencies are barely visible in healthy adults, they can be much more severe in elderly or malnourished patients.1

You need to base your diet on fruits and vegetables in order to prevent mineral or vitamin deficiencies.

Can Emanera be used during pregnancy and lactation

Animal studies don't indicate direct or indirect harmful effects on pregnancy, childbirth or postnatal development.2

Caution should be taken during pregnancy and this medication should be applied only if recommended by a healthcare professional.

Research on breastfeeding women has not been conducted, which is why there is not enough data to determine whether this drug is excreted into breast milk or not. It should not be used during breastfeeding.

Emanera and its use with other drugs

In the table below are listed drugs that should not be used in combination with this medicine:

Drug Reason why it should not be used together with Emanera
Atazanavir, ritonavir and other protease inhibitors Reduced efficiency of the protease inhibitors
Antidepressants Increasing blood levels of antidepressants - higher risk of side effects
Clarithromycin Increasing blood levels of Emanera
Clopidogrel Decreased effectiveness of Clopidogrel
Methotrexate Higher risk of Methotrexate side effects
Erlotinib Decreased effectiveness of Erlotinib

Emanera dosage

The usual dose for mild forms of heartburn or ulcers is 20 mg once daily (in the morning).

The usual dose for severe forms of heartburn or ulcers is 40 mg (20 mg in the morning and 20 mg in the evening).

Swallow the capsules whole with a glass of water. If you cannot swallow the capsule, you can open it and sprinkle in a glass of water and drink it immediately. Use plain, non-carbonated water.

How long the treatment lasts will depends on how severe the condition is.

It should not be used in children younger than 12 years.

Emanera side effects

Emanera side effects include:

  1. Decreased levels of sodium in the blood
  2. Reduced number of leukocytes in the blood
  3. Reduced number of platelets in the blood
  4. Insomnia
  5. Aggressiveness
  6. Hallucinations
  7. Confusion
  8. Depression
  9. Blurred vision
  10. Stomatitis
  11. Gastrointestinal candidiasis
  12. Photosensitivity
  13. Liver failure
  14. Muscle weakness
  15. Pain in the muscles and joints
  16. Interstitial nephritis

Call your doctor if you notice any side effects not listed here.


  1. NCBI link 1
  2. Emenera Patient Information Leaflet

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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