Fendex ER

Fendex ER - Uses | Dosage | Interactions

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Fendex ER is a medicine that contains felodipine. It belongs to the class of calcium channel blockers (also known as calcium antagonists). It works by lowering peripheral vascular resistance which leads to lowering of arterial blood pressure. It exerts high vascular selectivity and has almost no influence on cardiac conduction and contractility.

This medicine also lowers coronary vascular resistance and raises oxygen level in heart and thus leading to anti-anginal and anti-ischemic effects.

Studies have shown that this drug increases exercise tolerance in patients with stable angina and reduces myocardial ischemia in patients with vasospastic angina.

This medicine is usually well tolerated in diabetics and patients with high blood lipid levels as Fendex ER does not have significant effect on lipid and sugar blood levels. Patients suffering from congestive coronary insufficiency or asthma usually tolerate well this medicine. Studies have also shown that it is usually well tolerated in patients who have received kidney transplant.

Fendex ER reduces tubular reabsorption of sodium, because of which it exerts natriuretic (increases sodium excretion) and diuretic (increases water excretion) effects.

It does not affect potassium blood levels.


It is used for:

  • Hypertension treatment.
  • Prophylactic treatment of stable angina pectoris.

Contraindications and precautions

Fendex ER is contraindicated in following situations:

  • Pregnancy. Studies in rats in which this drug was used at high doses have shown that felodipine may increase risk of early postnatal death and due to such risk it must not be used during the pregnancy.
  • Unstable angina pectoris.
  • Severe aortic stenosis - abnormal narrowing of the aortic valve opening.
  • Cardiogenic shock.
  • Heart valve obstruction.
  • Decompensated heart failure.
  • During the heart attack and within a month after a heart attack.

Fendex ER may cause significant drop of blood pressure (hypotension), leading to rapid heartbeat (tachycardia). In these situations, ischemic damages of heart muscle may occur.

It must be used with extra precaution in patients with left ventricular dysfunction.

It is mostly excreted via liver, because of which blood levels of Fendex ER may be increased if used in patients with impaired liver function.

There is no enough data on its efficacy and safety in children. One study conducted in children aged 6/16 years (once daily for three weeks) has not confirmed its efficacy in treating hypertension. There is no data on its effects on children's growth and development.

Fendex ER, Pregnancy and Breastfeeding

Its use is absolutely contraindicated in pregnant women because studies in animals have demonstrated toxic effects on fetus.

It is excreted into breast milk. However, it is assumed that it has no negative effects on infants if breastfeeding mothers use therapeutic doses.


Usual dose is 2.5-5 mg once a day (in the morning). Dose can be increased in cases of severe hypertension or angina.

Do not crush or chew the tablets as it may reduce its effectiveness. Your doctor will determine the best dose for you.

This drug may be combined with beta blockers, ACE inhibitors, AR blockers and diuretics.

Take your tablet in the morning, before breakfast (on an empty stomach). You can also take the tablet with a light meal.

This drug may be combined with beta blockers, ACE inhibitors, AR blockers and diuretics.

Take the tablet in the morning, before breakfast (on an empty stomach). You can also take the tablet with a light meal.


Fendex ER should not be used in combination with following drugs:

  • Dolasetron - a medicine used to treat nausea and vomiting induced by chemotherapy. Concomitant use increases the risk of arrhythmias.
  • Edoxaban - a medicine used to treat blood clots. Concomitant use may lead to increased blood levels of edoxaban which increases the risk of life-threatening bleeding.
  • Rifampin and rifabutin - medicines used to treat tuberculosis. These drugs reduce concentration of Fendex ER in the blood which reduce its efficacy.
  • Itraconazole and ketoconazole - medicines used to treat numerous fungal infections. These drugs reduce blood concentration of Fendex ER in the blood which reduce its efficacy.

If you're using any other medications not listed above, please inform your doctor.

Adverse reactions

Fendex ER may cause following adverse reactions:

  • Fever.
  • Sore throat.
  • Sneezing.
  • Headache.
  • Ear congestion.
  • Rapid weight gain or loss.
  • Blurred vision.
  • Tunnel vision.
  • Productive cough.
  • Nausea.
  • Pale skin.
  • Wheezing.
  • Voice changes or loss of voice.
  • Redness of the face.
  • Feeling warmth.
  • Heartburn.
  • Tiredness.
  • Bleeding gums.
  • Constipation.
  • Stomach hyperacidity.
  • Stomach pain.
  • Insomnia.
  • Allergic reactions.

Call your doctor immediately if you're experiencing any side effects.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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