Ferrovin - Contraindications | Overdose | Effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Ferrovin 100 mg / 5 ml concentrate for solution for injection / infusion is a medicine which is applied only in health facilities (hospitals) and belongs to the group of antianemics. It contains iron (III) hydroxide and is used in the following cases:

  • When it's clinically necessary to quickly fill the iron deposits in the body
  • When patients have anemia and experience unbearable gastrointestinal discomfort, and the iron must be used as an infusion
  • In situations where oral iron preparations are ineffective because of present bowel disease


Ferrovin should not be applied in the following cases:

  • Patients who have a known allergy to Ferrovin or other iron preparations
  • Patients with anemia which are not caused by lack of iron (in which case Ferrovin will not be efficient)
  • Patients who have an iron metabolism disorder
  • Patients who have ever had an allergic reaction to iron
  • During the first three months of pregnancy


Iron preparations, such as Ferrovin, can sometimes cause an anaphylactic reaction, which can be fatal. It is therefore essential to have prepared everything (mostly drugs) that will be needed for anaphylactic shock treatment during application of Ferrovin infusion / injection. An allergic reaction occurs more frequently when applying higher doses of this medication.

Considering that the iron is metabolized in the liver, caution should be exercised when applying Ferrovin injection / infusion in patients who have an impaired liver function.

Ferrovin must not be used in patients who have late skin porphyria (Porphyria cutanea tarda - PCT), which is manifested by liver damage due to iron overload (excess iron in the body).

Patients who have an active infection must not use Ferrovin. Tell your doctor if you have a cold or you have recently had a flu or other infection.

Ferrovin should be administered as a slow infusion / injection, because rapid infusion may lead to hypotension.


Given that Ferrovin can be applied only in hospitals by trained medical personnel, your doctor will determine which dose is suitable for you.

Ferrovin is applied exclusively intravenously as a slow intravenous infusion (drip infusion). It should never be used as an intramuscular injection!

The dose depends on the patient's hemoglobin levels and body weight.

The dose of Ferrovin should be determined on the basis of total iron deficiency, which is calculated as follows:

TID = BW x (DHbl - MlHb) 0:24 x + IR

TID - total iron deficiency

BW - body weight (kg)

DHbl - The desired hemoglobin level (g / L)

MlHb - measured levels of hemoglobin (g / L)

IR - iron reserve (mg)

The desired hemoglobin level in patients weighing less than 35 kg is 130 g / L while iron reserve is 15 mg / kg. In patients over 35 kg desired hemoglobin level is 150 g / L while iron reserve is 500 mg.

When a doctor or clinical pharmacist calculates your iron deficiency, they will determine the dose in milligrams (mg) you need to receive.

Dosage calculations should be done only by trained physicians and clinical pharmacists.

The total Ferrovin single dose should not exceed 200 mg.

Ferrovin can be reconstituted only with 0.9% saline to be given as an infusion.


Application of larger doses than recommended can lead to iron overload and the appearance of a disorder known as hemosiderosis - a disorder that leads to bleeding most often in the lungs and liver.

Ferrovin during pregnancy and breastfeeding

There are some data that suggest that the administration of Ferrovin during pregnancy has no adverse effects on the fetus but there are no clinical studies to confirm this fact.

Ferrovin should be applied only in pregnant women who have severe anemia that may endanger the life of the mother or fetus. In this case, you should first try oral iron supplementation but if that is not effective, then Ferrovin should be applied.

Ferrovin probably does not pass into breast milk and studies in animals have shown no adverse effects if Ferrovin is administered during lactation.

Interactions with food and other drugs

Ferrovin should not be administered concurrently with other oral iron supplementation, because it reduces their effectiveness.

Five days after you stop receiving Ferrovin injection / infusion, your doctor may recommend that you start taking oral iron supplements.

Ferrovin adverse effects

The most common reported side effects of Ferrovin are:

  • Low blood pressure (especially when applied in the form of injections)
  • Redness and pain at the injection site
  • Nausea
  • Taste changes (metallic taste in your mouth)
  • Chills

Uncommon side effects (occurring in 1% - 0.1% of patients):

  • Dizziness
  • Headache
  • Rapid heartbeat
  • Palpitations
  • Narrowing of the bronchi and consequently difficulty in breathing
  • Vomiting
  • Abdominal pains
  • Erythema
  • Exanthema
  • Muscle cramp
  • Muscle pain
  • Chest tightness

Rare side effects (occurring in 0.1% - 0.01% of patients):

  • Anaphylactic reaction
  • Arthritis
  • Edema of peripheral parts of the body
  • Asthenia (chronic exhaustion)
  • Paresthesia
  • A sudden, transient loss of consciousness (do not drive a car for a couple of hours after receiving a Ferrovin injection / infusion)
  • Burning sensation

This list may not include all side effects of the Ferrovin. Contact your doctor if you suspect that Ferrovin caused some other adverse effects.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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