Finpro - Precautions | Dosage | Interactions
Finpro is a drug containing finasteride as an active substance and belongs to a class of drugs known as 5 alfa-reductase inhibitors. 5 alfa-reductase is an enzyme whose main role is metabolizing testosterone into dihydrotestosterone (DHT). The main function of dihydrotestosterone is the development of the external genitalia, but is also responsible for prostate growth. Too much of DHT in the body lead to the excessive prostate growth causing pressure on the urinary tube (urethra), which consequently causes the following symptoms:
- Frequent urination.
- Urgent urination.
- Slow urine stream.
- Difficulty urinating.
Finpro acts by reducing the production of dihydrotestosterone which reduces prostate growth and improves the symptoms of benign prostate enlargement (BHP).
Finpro can only be used in men.
The primary route of elimination of the drug is via faeces (about 57%) while about 39% is excreted via urine in the form of a metabolites. Most of the drug is metabolized in the liver via CYP3A4 enzymes. The oral bioavailability of the drug is high and is about 80%. The maximum concentration of the drug in the blood is achieved 2 hours after oral administration. Food does not affect its absorption, and it can be taken regardless of the meal. Approximately 93% of the drug is bound to plasma proteins.
The volume of distribution is 76 liters while the plasma clearance of finasteride is 165 ml / min.
The elimination half-life depends on age and in men aged 18-60 years, the elimination half-life is 6 hours, while in men above the age of 70, the elimination half-life is increased to 8 hours, which is of no clinical significance. Studies have shown that in patients with kidney damage, the body increases the faecal excretion compensating for decreased urine excretion. Therefore, it is not necessary to adjust the dose of Finpro in non-dialysed patients with impaired renal function.
Man whose partner is planning pregnancy or is pregnant must not use Finpro tablets. The sperm of men who use this medicine may contain small amounts of this medicine which can disturb normal development of genital organs of the unborn baby.
Always use appropriate methods of contraception while taking this medicine.
This drug is contraindicated in women as well as in children.
Pregnant women should avoid touching broken or crushed tablets of this medicine due to a possible risk of absorption and unwanted effects on the fetus.
Patients who need to have PSA test (prostate-specific antigen test) must inform the physician that they are taking Finpro, as studies have shown that finasteride reduces the PSA levels by 50%.
Since most of the drug is metabolized via liver enzymes, patients with impaired hepatic function must use this medicine with extra precaution.
Side effects, such as: decreased volume of ejaculate, impotence, decreased libido, breast enlargement, pain and increased breast sensitivity may occur. Cases of breast cancer in men who took this medicine have also been reported. Tell your doctor if you notice any changes in the breast.
Pregnancy and Breastfeeding
FDA category: X.
Finpro should not be used in pregnant and breastfeeding women! It is intended only for use in men.
The usual dose is 5 mg once a day, without regard to meals. Make sure you take Finpro tablets each day at the same time.
Your doctor will determine the dose that is best for you.
No clinically significant interactions have been reported, but Finpro should not be used concomitantly with the following medicines because they may increase the concentration of Finpro in the blood, increasing the risk of side effects:
- Diltiazem - a calcium antagonist used to treat cardiovascular diseases.
- Nelfinavir - an HIV protease inhibitor used to treat HIV infection.
- Fluconazole, itraconazole and voriconazole - medicines used to treat fungal infections.
- Fluvoxamine - a medicine used to treat an obsessive-compulsive disorder.
- Saquinavir - an antiretroviral drug used to treat HIV infection.
- Nefazodone - a medicine used to treat depression.
Simultaneous administration with a medicine called tacrolimus (an immunosuppressant drug) may lead to an increase in the concentration of both drugs which increases the risk of their side effects.
Tell your doctor about all medicines and the herbal remedies you are taking.
Finpro can cause the following side effects:
- Impotence (occurs in 8.1% of patients).
- Decreased libido (occurs in 6.4% of patients).
- Ejaculation problems.
- Changes in liver function.
- Breast tenderness.
- Testicle pain.
- Decreased ejaculate volume.
- Breast cancer.
- Allergic reactions.
Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.
If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.