Flixotide - How to use | Dosage | Effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Flixotide suspension for inhalation 50 micrograms / dose contains fluticasone propionate and belongs to the group of corticosteroids, which are used for the prevention of asthma attacks. It shows an anti-inflammatory effect on the bronchial tubes, which reduces the incidence of asthma attacks. This drug also reduces swelling in the lungs.

Note: Flixotide is not used to treat asthma attacks. It is used only for the prevention of asthma attacks. Taking this drug when an asthma attack has already occurred will not help you.

Contraindications and precautions

The only contraindication to the use of this drug is a hypersensitivity to the active substance - fluticasone propionate.

Precautions should be exercised in the following situations:

  • If you have had tuberculosis. Use of this drug in such patients increases the risk of recurrence of the tuberculosis.1
  • If your breathing becomes more difficult after application of this drug, immediately discontinue use and consult your doctor.
  • If you switch from tablets to this inhalation drug, you may notice a worsening of symptoms. If you notice your symptoms get worse, contact your physician immediately.
  • If you are pregnant.

Flixotide, pregnancy and breastfeeding

In a study conducted in the UK, major congenital malformations in pregnant women taking fluticasone were followed during the period from 2000 to 2010 and it was not found that fluticasone increases risk of major congenital malformations if applied during the first trimester. However, animal studies have shown teratogenic properties of this drug (decreased body weight of newborns). Consult your doctor before you start taking this drug during pregnancy.

Since it is excreted in breast milk in very low concentrations it is not expected that this drug will have any adverse effects on the baby.

How to use

This drug is administered with the help of inhalers. Before you inhale the prescribed dose, first exhale all the air. Then take a deep breath and inhale the intended dose from an inhaler and hold your breath as long as you can.

Dosage for adult patients

The usual dose is 100 micrograms twice daily for mild forms of asthma and 250-500 micrograms twice daily in severe forms of asthma.

The maximum daily dose is 1000 micrograms twice daily.

Dosage for children aged 4-16 years

Usual dose is 50-100 micrograms twice daily. The maximum daily dose is 200 micrograms twice daily.

In children younger than 4 years, a single dose should not exceed 50 micrograms.

Sometimes it is necessary to use an additional dose due to stressful situations (because stress may have triggered release of adrenaline, which narrows the bronchi and cause asthma attacks).


Drugs that can increase the effects of Flixotide:

  • Clarithromycin (an antibiotic)
  • Amprenavir, Atazanavir (HIV protease inhibitors - drugs for AIDS treatment)
  • Boceprevir - a drug for hepatitis C treatment
  • Inhibitors of antidiuretic hormone (conivaptan)
  • Cobicistat - a drug used to amplify the effect of drugs used in the treatment of AIDS

Concomitant use with these drugs increases the risk of Flixotide side effects.

Side effects

Flixotide may cause the following side effects:

  • Fungal infections in the mouth and throat. The incidence of this adverse effect can be reduced if you practice good hygiene habits (brush your teeth frequently and mouthwash regularly)
  • Inflammation of the throat and mouth
  • Painful or more sensitive mouth
  • Hoarseness
  • Slowed growth of children and adolescents
  • Nasal congestion
  • Runny nose
  • Cough
  • Swelling of the face
  • Swelling of the throat
  • Swelling of the eyes
  • Swelling of the hands and legs
  • Allergic reaction

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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