Flucil - Precautions | Dosage | Interactions

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Flucil is a drug available in Australia and contains active substance called flucloxacillin. It inhibits one or more enzymes involved in synthesis of peptidoglycan chains - which are one of the main component of bacterial cell wall. Thus, Flucil decreases strength of bacterial cell wall and leads to lysis (destruction) of bacteria. Flucil belongs to derivatives of penicillin (antibiotics).

Therefore, Flucil is used to treat following infections:

  • Cellulitis.
  • Ecthyma - ulcerative skin infection caused by streptococci.
  • Folliculitis - inflammation of hair follicles, caused by bacterial infection.
  • Impetigo - bacterial skin infection that most commonly occurs in children.
  • Panaricium - purulent infection of tissues of fingers.
  • Paronychia - infection that develops around a fingernail.
  • Mastitis - infection of breast tissues, usually associated with breastfeeding.
  • Blain - skin ulcer.
  • Lung abscess - necrosis of the pulmonary tissue caused by bacterial infection.
  • Bacterial pneumonia - inflammation of the pulmonary tissue usually caused by bacteria.
  • Arthritis - joint inflammation sometimes caused by bacteria.
  • Osteomyelitis - infection that develops in bone tissue.
  • Endocarditis - infection of inner lining of the heart.


Flucil is contraindicated for ocular or subconjunctival administration.

It is also absolutely contraindicated in patients with history of hypersensitivity/allergic reactions to beta-lactam antibiotics, such as: penicillin, amoxicillin, ampicillin, cloxacillin, cephalexin, cefazolin, cefadroxil, cefalotin, cefaclor, cefprozil, cefotetan, cefuroxime, cefdinir, cefpodoxime, ceftriaxone, ceftobuten and cefepime.

It should be used with extra precaution in patients who:

  • Have hepatic impairment,
  • Have renal impairment.
  • Are above the age of 50.

It can cause hyperbilirubinaemia in newborns, so it should be used with extra precaution and under strict medical supervision in newborns.

If you have had jaundice (yellowish tinge to the skin and the whites of the eye) that occurred due to the antibiotic use, then you should avoid use of this drug.

Use of Flucil during Pregnancy and Breastfeeding

There are limited data about its use during pregnancy. Results from animal studies have shown no teratogenic effect. However, Flucil may be used during pregnancy only if your doctor estimates that potential benefits justifies the potential risk to the fetus.

Apart from the risk of sensitization, there are no other harmful effects on the infants, so Flucil may be used during breastfeeding if recommended by pediatrician.


Flucil may be found in different dosage forms:

  • Flucil 250 mg/5 ml powder for oral liquid.
  • Flucil 125 mg/5 ml powder for oral liquid.
  • Flucil 500 mg powder for injection.
  • Flucil 1000 mg powder for injection.

Recommended dosage for Flucil 250 mg/5 ml powder for oral liquid is shown in table below:

Age Recommended dosage
> 10 years 250 mg four times a day (5 ml four times a day).
2-10 years 125 mg four times a day (2.5 ml four times a day).
< 2 years 62.5 mg four times a day (1.25 ml four times a day).

Recommended dosage for Flucil 125 mg/5 ml powder for oral liquid is shown in table below:

Age Recommended dosage
> 10 years 250 mg four times a day (10 ml four times a day).
2-10 years 125 mg four times a day (5 ml four times a day).
< 2 years 62.5 mg four times a day (2.5 ml four times a day).

Flucil 125 mg/5 ml is more suitable for children under the age of 10.

Flucil may also be administered intravenously (as a slow vein injection) or intramuscularly. Injection must be given by trained healthcare professionals.

Injection can also be applied directly into pleura - tissue that protect lungs (so-called intrapleural administration). Usual dosage in adults for intrapleural administration is 250 mg once a day.

Flucil may be given as intra-articular injection (directly into a joint) and usual dosage in adults for intra-articular administration is 250-500 mg once a day.

Recommended adult dosage for intramuscular and intravenous administration is 1000-6000 mg daily, divided in 3-6 doses.

The single dose administered as an intramuscular injection in adults should not be greater than 2000 mg.

Maximum daily dose for adults is 12 g (12 000 mg).

Recommended dosage for intramuscular/intravenous administration in children under the age of 12 is 25 - 50 mg/kg of body weight daily (divided in 3-4 doses). The single dose should not be greater than 33 mg/kg.

Your doctor will determine what is the best dose.


Flucil should not be used concomitantly with following drugs:

  • Probenecid - drug used to treat gout. Probenecid decreases renal excretion of Flucil, thus increasing the amount of time that Flucil stay in the body and this increases the risk of side effects.
  • Bacteriostatic antibiotics, such as: chloramphenicol, clindamycin, tetracycline, doxycycline, trimetophrim, sulfadiazine, sulfamethoxazole, erythromycin, telithromycin, clarithromycin, azithromycin, nitrofurantoin, ethambutol, etc. Concomitant use with these drugs may interfere with Flucil effects.
  • Anticoagulant agents, such as: warfarin and acenocoumarol. Flucil can decrease anticoagulant effects of these drugs.
  • Doxorubicin, epirubicin - used to treat cancer. Flucil can decrease blood concentration of these drugs, thus decreasing their efficacy.
  • Methotrexate - drug used to treat leukemia, breast cancer, rheumatoid arthritis, stomach cancer, etc. Flucil can increase blood serum levels of Methotrexate, thus increasing risk of side effects.

Inform your doctor about all medicines you are taking.

Side effects

Flucil may cause following side effects:

  • Low concentration of neutrophils.
  • Low platelet concentration.
  • Abnormal breakdown of erythrocytes - hemolytic anemia.
  • High levels of eosinophils - eosinophilia.
  • Allergic reaction (including severe forms).
  • Diarrhea.
  • Hepatitis.
  • Yellowing of the skin and whites of the eyes (jaundice).
  • Interstitial nephritis.
  • Muscle aches.
  • Joint pain.

Inform your doctor if you are experiencing any side effects.


  1. NCBI link

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