Fluco Sandoz - Effects | Dosage | Interactions
Fluco Sandoz is a medicine produced by Swiss company, Novartis (Bangladesh) Ltd and as an active substance contains fluconazole and belongs to a group of antifungal drugs that are classified into triazoles according to chemical structure. It has fungistatic effects and prevents the growth of fungi and is therefore used in the treatment of fungal infections, such as:
- Fungal infections of the brain (meningitis caused by a fungus called cryptococcus)
- Fungal infections of the lungs and bronchi caused by a strain of fungus called Coccidioides immitis
- Fungal infection of the heart, lung, and urinary tract caused by Candida
- Fungal infections of the mucous membranes in the mouth and throat
- Fungal infections of the vagina and penis
- Onychomycosis (fungal infections of the nails)
- Fungal infection of the skin
- Athlete's foot
Fluco Sandoz is also used in the prevention of the following conditions:
- Prevention of recurrence of fungal infections of the brain
- Prevention of recurrence of fungal infections of the vagina and penis
- Prevention of recurrence of fungal infections of the mucous membranes
How Fluco Sandoz works
Inhibition of the cytochrome P450 enzyme which leads to preventing the growth of fungi and preventing the spread of infection. This drug generally specifically binds to cytochrome P450 in the fungus, but sometimes a small percentage of the drug may bind to a liver cytochrome P450 enzymes in humans which may effect the metabolism of other drugs. Therefore, this drug has many major interactions with as many as 150 other drugs, and great caution is necessary if you are using any other medication concomitantly with Fluco Sandoz.
Precautions and interactions with other drugs
Because of the impact on cytochrome P450, Fluco Sandoz may change the metabolism of the following drugs:
- Quinidine (antiarrhythmic)
- Terfenadine and astemizole (antihistamines)
- Pimozide (an antipsychotic)
- Cisapride (used for digestive problems)
- Dolasetron (a drug used for the treatment of emesis induced by chemotherapy)
We have mentioned these drugs because they can affect the heart (prolongation of the QT interval) and an increase in their concentration in the blood can lead to serious heart disorders! Therefore, the simultaneous use of Fluco Sandoz with the above-mentioned drugs is not recommended!
In addition, Fluco Sandoz may increase the concentration and consequently the risk of side effects of the following drugs:
- Hydrocodone and fentanyl (narcotic painkillers)
- Lovastatin, cerivastatin and atorvastatin (medicines for lowering high cholesterol)
- Flibaserin (drug to treat decreased libido in postmenopausal women)
- Tacrolimus (immunosuppressant)
- Brexpiprazole (antipsychotic)
- Ergotamine (anti-migraine drug)
- Cobimetinib (a drug for the treatment of metastatic melanoma)
- Citalopram (antidepressant)
- Colchicine (medicine for gout)
Note that this list is not complete and Fluco Sandoz interacts with many other drugs. You must tell your doctor about all the medicines you are taking.
Moreover, you must pay attention to interactions with other drugs, and increased caution is also necessary in the following situations:
- If you have low or high levels of potassium or magnesium in the blood
- If you have heart disorders
- If you have liver problems
Cases of severe liver damage due to the use of this drug have been reported very rarely.
If you notice changes in your skin, you must immediately call your doctor as this can be a sign of severe disease known as exfoliative dermatitis.
Pregnancy and breastfeeding
Fluco Sandoz should not be used during pregnancy and breastfeeding unless your doctor advised you to.
How to take Fluco Sandoz and recommended dosage
The following table provides a recommended dosage for patients above the age of 18 according to PIL:
|Indication/type of infection||Dosage regimen|
|Cryptococcal meningitis||Take 400 mg on the first day of treatment and then take 200 mg or 400 mg once a day for 6-8 weeks. In severe cases of meningitis, the dose can be increased up to 800 mg daily.|
|Coccidiomycosis||200-400 mg once a day for 11 to 24 months. In severe forms, the dose should be increased up to 800 mg daily.|
|Fungal infections of the mucous membranes in the mouth and throat||200-400 mg on the first day of treatment, and then 100-200 mg daily|
|Fungal infections of the vagina and penis||150 mg taken as a single dose (only one tablet for one day)|
|Onychomycosis||Usual recommended dose is 50 mg once a day. Sometimes 150-300 mg is applied once a week depending on your doctor's advice|
|Athlete's foot||300-400 mg weekly for 4-6 weeks|
|Infections caused by Candida||800 mg on the first day of treatment and then 400 mg once a day. The duration of therapy will be determined by your doctor.|
The drug is taken orally with or without food.
It can be used in children younger than 18 years if recommended by a pediatrician.
Fluco Sandoz may cause the following side effects:
- Sudden difficulty breathing
- Skin rash
- Exfoliative dermatitis
- Liver damage
- Tickling sensation
- Electrocardiographic changes
Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.
If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.