Flugalin

Flugalin - Interactions | Adverse effects

Flugalin contains flurbiprofen and belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). This drug inhibits the synthesis of prostaglandins and therefore exerts analgesic, antipyretic and anti-inflammatory properties. Studies have shown that this drug inhibits the effect of acetylsalicylic acid (Aspirin) on platelet aggregation which is why it should not be used in patients who take Aspirin for thrombotic disorders.

When is Flugalin applied

Flugalin is mainly used to relieve symptoms in the following conditions:

  • Ankylosing spondylitis - relieves inflammation and pain
  • Periarthritis - relieves inflammation and pain
  • "Frozen shoulder" - relieves inflammation and pain
  • Overstretched muscle - relieves pain
  • Inflammation of the joint lining (bursitis) - relieves inflammation and pain
  • Dysmenorrhea - relieves pain

What you need to know before you start taking Flugalin

Given that this drug inhibits the synthesis of prostaglandins in the stomach mucosa, it can cause irritation and damage to the gastric mucosa, which leads to the occurrence of stomach ulcer and bleeding. One research conducted on 40 subjects found that the risk of ulcers depends on the dose and body weight. Patients taking more than 5.95 mg / kg per day have a higher risk of ulcers and bleeding.1

Flugalin cannot be used in patients with aspirin-induced asthma, or in patients who have already had a bronchospasm when they consumed some of the NSAIDs.

Flugalin is contraindicated in patients who have any of the following diseases:

  • Renal insufficiency
  • Hepatic insufficiency
  • Heart insufficiency

Flugalin, pregnancy and breastfeeding

Inhibition of prostaglandin synthesis may affect embryo development and therefore Flugalin should not be used during pregnancy.

This drug is excreted in breast milk in small concentrations and should not be used during breastfeeding.

Dosage

The usual dose is 50 mg of Flugalin 3-4 times a day, although it is recommended to calculate the dose according to your body weight. It should not be used in a dose greater than 300 mg per day.

Always take this medicine after a meal because that way, you will reduce the risk gastrointestinal side effects.

It should not be applied in children under 12 years.

In elderly patients, the dose should be adjusted because they have weakened kidney function.

Interactions

This drug may reduce the effects of the following drugs:

  • Angiotensin converting enzyme inhibitors, such as: enalapril, lisinopril, ramipril, and others.
  • Diuretics
  • Angiotensin II receptor blockers

Also, Flugalin should not be used with the following drugs:

  • Cardiac glycosides (digitalis preparations). Flugalin can worsen heart failure.
  • Acetylsalicylic acid. Concomitant use is not recommended due to the potential increased risk of adverse reactions.
  • Lithium. Flugalin reduces the excretion of lithium which can potentially increase the risk of adverse reactions.
  • Corticosteroids. Concomitant use increases the risk of gastrointestinal bleeding.
  • Quinolone antibiotics (ciprofloxacin, norfloxacin, ofloxacin and levofloxacin). In animal studies, it was shown that there is an increased risk of seizures if quinolone antibiotics are administered concurrently with this drug.
  • Zidovudine (medicine used to treat AIDS). Flugalin increases the risk of hematological toxicity of zidovudine.

Adverse effects

The only limiting factor in the application of this drug is its harmful effect on the gastric mucosa, and it is necessary to call your doctor immediately if you notice any of the following side effects:

  • Blood in the stool (melena) or tar colored stool
  • Vomiting blood (haematemesis)
  • Severe pain in the stomach
  • Peptic ulcer

Other side effects of this drug include:

  • Flatulence
  • Dyspepsia
  • Stomatitis
  • Nausea and vomiting
  • Diarrhea
  • Constipation
  • Non-specific allergic reaction
  • Dyspnea (shortness of breath)
  • Toxic epidermal necrolysis (severe skin damage)
  • Perturbations of the immune system
  • Psychiatric disorders
  • Aseptic meningitis
  • Visual disturbances
  • Disorientation
  • Hepatitis
  • Photosensitivity

References

  1. NCBI link