Fluomizin - Interactions | Side Effects | Use

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Fluomizin vaginal tablets comprises a quaternary ammonium compound called dequalinium chloride. It has a wide spectrum of antibacterial and antifungal activity. It acts against both Gram positive and Gram negative bacteria. It is therefore used in the treatment of vaginal infections caused by bacteria, fungi and protozoa (Trichomonas vaginalis). Its efficacy has been confirmed in numerous clinical studies while development of resistance to this drug has not been reported (development of resistance is a fundamental problem with the use of antibiotics).

The effectiveness of this drug was compared with other known vaginal preparations for the treatment of vaginal infections (povidone iodine and clotrimazole), and it was found that this drug has the highest activity. It is only ineffective in infections caused by a microorganism called Proteus mirabilis.1 It was also compared with clindamycin (an antibiotic) and it was shown that these drugs are equally effective in the treatment of bacterial vaginosis.2

When Fluomizin should not be used

Contraindications to the use of Fluomizin vaginal tablets are:

  • Sensitization to the active substance (dequalinium chloride)
  • Ulcers in the vaginal area
  • Girls who have not had their first period

Fluomizin and its use during pregnancy and lactation

Flumozin can be used during pregnancy. In four clinical studies, 181 pregnant women had been applying this drug and no adverse effects to the fetus were recorded.

Because the treatment lasts only 6 days and on the basis of known pharmacokinetic data, harmful effects to the infants are not expected.

How to apply Fluomizin

The recommended dose is one vaginal tablet (10 mg) per day, at bedtime for 6 days.

Since Fluomizin contains insoluble auxiliary substances, they may appear on your underwear. However, this has no impact on the effectiveness of this drug. Sometimes, if applied in a dry vagina, Fluomizin vaginal tablets will not fall apart but will fall out unchanged. In this case, you need to wet the Flumozin vaginal tablet and then apply it deep into the vagina. Patients are advised to regularly carry cartridges, to keep good hygiene, to regularly change their underwear and towels and to wash them at 90 degrees.

Therapy should last 6 days even if you feel better. During the menstrual cycle, stop using this medicine and continue as soon as the menstrual cycle ends.


For now, interactions with other drugs have not been recorded.

Fluomizin adverse reactions

This medicine rarely causes adverse reactions. Occasionally, lesions on the surface of the vaginal area and vaginal bleeding may appear, but only in cases when vaginal mucosa is already damaged. Fever may also occur and in this case, the use of this drug should be discontinued.


  1. NCBI link 1
  2. NCBI link 2

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