Gynoflor vaginal tablets (suppositories)

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Gynoflor vaginal tablets (suppositories) contain the two active substances:

  • Lactobacillus acidophilus
  • Estriol

Lactobacillus acidophilus is a non-pathogenic bacteria (it does not cause infection), and is a major component of microbiological vaginal flora. It has a positive effect on the vagina because it breaks down glycogen to lactic acid, which lowers the pH in the vagina and the resulting acidic environment prevents the growth of pathogenic bacteria and fungi in the vagina.

Estriol is actually a derivative of estrogen (female hormone) and works by accelerating the maturation of the vaginal epithelium. It also works by accumulating glycogen which is actually a food for Lactobacillus acidophilus bacteria.

When is Gynoflor used?

Gynoflor exerts beneficial effects in the following situations:

  • Atrophic vaginitis - a condition that occurs due to decreased levels of estrogen in women, usually in postmenopausal women. Because of decreased estrogen, postmenopausal women are more susceptible to vaginal infections. Then it is useful to apply Gynoflor vaginal tablets.
  • Sometimes due to the use of antibiotics, a disturbance of the vaginal flora may occur and in that case, Gynoflor vaginal tablets should be used.
  • Mild bacterial or fungal vaginal infections, when there is no need to take antibiotics.

Gynoflor may also be useful in the prevention of vaginal infections.

When Gynoflor must not be used?

Gynoflor must not be used in the following conditions:

  • In women who have endometriosis
  • In women who have estrogen-dependent cancer
  • In women who have vaginal bleeding of unknown cause
  • In patients younger than 16 years

Since the small amount of the pharmacologically active agent (estriol) can be absorbed through the vaginal mucosa into the blood, systemic effects of the hormone may be manifested. Thus, Gynoflor must be very carefully applied in the following conditions:

  • Thrombosis or other circulatory problems
  • Epilepsy
  • Hypercholesterolemia
  • Diabetes
  • Migraine
  • Porphyria
  • Heart disease
  • Kidney disease
  • Liver disease

If you have any of the conditions listed above, you need to consult a doctor before you start the application of Gynoflor.

This medicine is only intended for vaginal application!

Gynoflor use during pregnancy and lactation

Gynoflor can be used during pregnancy and breastfeeding, because it does not have any adverse effects for the baby.

Given that the concentration of estriol in pregnant women is up to a thousand times higher than in women who are not pregnant, Gynoflor cannot have an impact on the pregnancy or the baby's health.

The Gynoflor Patient Information Leaflet states that 159 pregnant women used Gynoflor without any side effects.

Gynoflor - how to use and which dose to apply?

You should apply one or two vaginal tablets daily for 6 to 12 days. The Vaginal tablet should be inserted deep into the vagina. The recommended position for this kind of application is to lie on the bed with your knees bent and tilted towards the chest.

Do not apply this medication during the menstrual cycle.

The recommended daily dose for atrophic vaginitis is one vaginal tablet in the first week, and then two vaginal tablets for another week.


There are no reported cases of an overdose.

Gynoflor and concomitant application with other drugs

Gynoflor cannot be applied together with antibiotics (anti-infective drugs).

Gynoflor side effects

Given that this medication manifests mostly local effects, it does not cause serious side effects, but only mild, such as: burning sensation and itching which usually goes away quickly. In some studies, therapy needed to be discontinued because of unbearable itching.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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