Hypnodorm - Dosage | Overdose | Effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Hypnodorm is a medicine that contains an active substance called flunitrazepam and belongs to the benzodiazepine family of medicines. It is used to treat severe forms of insomnia when the use of other drugs has not yielded results. It is used only as a short-term therapy because long-term use can cause physical and psychological dependence.

In some countries it is used as a premedication prior surgery.

The effects of this medicine starts 15-20 minutes after oral administration oral route and last for 4-6 hours. It has similar characteristics as diazepam, but it has shown a more potent sedative effect than diazepam. It is also characterized by a strong amnesia of events that occur while the patient is under the influence of this drug.

Due to possible abuse, this medicine is only available with a doctor's prescription.


Like all benzodiazepines Hypnodorm may also cause respiratory depression, which is why it is contraindicated in patients with chronic or severe respiratory diseases. The use of this drug in such patients can lead to difficulty breathing.

In addition to potent sedative effects, Hypnodorm also acts as a muscle relaxant, which is why it is contraindicated in patients suffering from myasthenia gravis (an autoimmune disease characterized by muscle weakness). The use of Hypnodorm tablets can worsen the symptoms of myasthenia gravis.

Hypnodorm may adversely affect control of ventilation during sleep, which is why it is contraindicated in patients with sleep apnea syndrome.

It should not be used in patients with severe hepatic impairment.

Hypnodorm should be used only with extra precaution in patients:

  • Who have blood disorders.
  • Who have low blood pressure.
  • Who suffer from schizophrenia.
  • With depression.
  • Who suffer from mental disorders.
  • Who have glaucoma.
  • Who have a history of convulsions/seizures.

You should not drive or operate machinery while taking this medicine.

Hypnodorm, Pregnancy and Breastfeeding

The use of Hypnodorm tablets during pregnancy is contraindicated. Long-term use, especially during the last trimester, may lead to withdrawal symptoms in the newborn. Respiratory depression may develop shortly after birth!

Due to possible toxic effects on infants, doctors should decide whether to discontinue breastfeeding or drug.


The usual dose for adult patients is 1-2 mg, 15-20 minutes before going to bed.

Your doctor will determine the dose that is best for you. Do not exceed the dose prescribed by your doctor.

In patients over 60 years of age, the usual dose is 0.5-1 mg, 15-20 minutes before going to bed.

Hypnodorm is usually not used for more than 4-5 days.

You can take a tablet with a meal because the food does not affect the absorption of this medicine.

You should never stop taking Hypnodorm tablets suddenly. Consult a doctor before stopping the Hypnodorm.


If you take higher doses than recommended by your doctor, you may develop following symptoms:

  • Muscle weakness.
  • Tiredness / malaise.
  • Drowsiness.
  • Confusion.
  • Loss of consciousness.
  • Shallow breathing.

Contact your doctor immediately if you are experiencing any of the above symptoms.


Hypnodorm can interact with the following drugs:

  • Opioid analgesics, such as:
    • fentanyl
    • buprenorphine
    • alfentanil
    • morphine
    • hydromorphone
    • methadone
    • tramadol
  • Muscle relaxants, such as:
    • baclofen
    • chlorzoxazone
    • tizanidine
    • cyclobenzaprine
    • dantrolene
  • Other benzodiazepines, such as:
    • diazepam
    • nitrazepam
    • flurazepam
    • clonazepam
    • lorazepam
    • bromazepam
    • midazolam
    • alprazolam
  • Tricyclic antidepressants, such as:
    • nortriptyline
    • trimipramine
    • desimipramine
    • protryptiline
    • amitriptyline
    • imipramine
  • Selective serotonin reuptake inhibitors, such as:
    • sertraline
    • fluoxetine
    • paroxetine
    • fluvoxamine
    • citalopram
    • escitalopram
  • Phenothiazine antipsychotics, such as:
    • prochlorperazine
    • chlorpromazine
    • fluphenazine
    • thioridazine
  • Butyrophenone antipsychotic, such as: droperidol and haloperidol.
  • Pramipexole (drug used to treat restless legs syndrome).
  • Cisapride (gastroprokinetic agent).
  • H2 antihistamines used in the treatment of allergies, such as:
    • loratadine
    • cetirizine
    • desloratadine
    • diphenhydramine
    • levocetirizine
  • Medicines used to treat epilepsy, such as: lamotrigine, valproic acid and carbamazepine.
  • Drugs used for AIDS treatment, such as:
    • atazanavir
    • indinavir
    • atazanavir / cobicistat
    • saquinavir
    • efavirenz

Side effects

Hypnodorm can cause the following side effects:

  • Hangover.
  • Stomach upset.
  • Slurred speech.
  • Confusion.
  • Dry mouth.
  • Delusions.
  • Night mares.
  • Hallucinations.
  • Amnesia.
  • Aggressive behavior.
  • Allergic reactions.


  1. PIL

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If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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