Hysone 4

Hysone 4 - Precautions | Dosage | Interactions

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Hysone 4 is a medicine that contains an active substance called hydrocortisone. It belongs to group of medicines called corticosteroids. It is used in patients who have Addison's disease (rare endocrine disorder in which adrenal gland does not produce sufficient amount of steroid hormones) or adrenocortical insufficiency.

This medicine exerts potent anti-inflammatory effects.

Precautions

Hysone 4 is contraindicated for use in patients who:

  • Have systemic fungal infections. Hysone 4 may exacerbate symptoms in these patients. Concomitant use of amphotericin (drug used to treat fungal infections) with Hysone 4 may lead to congestive cardiac insufficiency, therefore concomitant use must be avoided.
  • Are using live vaccine. Hysone 4 may weaken one's immune system (immunosuppressive effect) and this can cause complications in recently vaccinated persons.
  • Are allergic on hydrocortisone or other corticosteroids.

Lowest effective dose should be used whenever possible. If you are using high doses or you've been taking Hysone 4 for longer periods of time, your doctor will explain how to gradually reduce the dose. Abrupt discontinuation of Hysone 4 may lead to adrenal insufficiency.

Hysone 4 should be used with extra precaution in patients who suffer from hypothyroidism or liver cirrhosis, as effect of Hysone 4 might be increased in these patients.

There are reports of corneal perforation in patients with ocular herpes simplex taking corticosteroids, therefore Hysone 4 should be avoided in these patients.

This medicine should not be used in patients who recently suffered heart attack or have cerebral malaria.

Since it may cause dizziness and impaired vision, you should avoid driving a car (or other motor vehicle) or operating machinery, while on Hysone 4 therapy.

Patients who have pheochromocytoma (adrenal gland carcinoma) should not use this medicine, as it may lead to pheochromocytoma crisis, which can have fatal outcome.

Dosage

Hysone is available in two dosage forms:

  • Hysone 4 mg tablets.
  • Hysone 20 mg tablets.

Dosage should be adjusted as per clinical response of the patient. Doctor will always prescribe you lowest effective dose to reduce the risk of side effects.

Your doctor will tell you how much and how long to use this drug. Never change the dose on your own.

It should be used very cautiously in elderly, as they are more sensitive to the side effects of Hysone 4, such as hypertension, hyperglycemia, infections and osteoporosis.

Use of Hysone 4 During Pregnancy and Breastfeeding

There are no clinical studies on use of this drug during pregnancy. Use of corticosteroids during pregnancy in animals may cause cleft palate or slow the intrauterine growth. Theoretically, corticosteroids may cause hypoadrenalism in newborns whose mothers took them while pregnant. If corticosteroids were used during pregnancy, all newborns should be carefully monitored for signs/symptoms of hypoadrenalism. This medicine should be used during pregnancy only if potential benefits to the mother outweigh risk to the fetus.

Corticosteroids pass into breast milk, therefore breastfeeding should be avoided while taking Hysone 4.

Interactions

Hysone 4 should not be used concomitantly with following drugs:

  • Anticonvulsants (drugs indicated for treatment of epilepsy), such as: phenobarbital, carbamazepine and phenytoin. These drugs speed up the metabolism of Hysone 4 and decrease its effectiveness.
  • Rifampin - drug indicated for treatment of tuberculosis. Concomitant use should be avoided as Rifampin speeds up the metabolism of Hysone 4 and decrease its effectiveness.
  • Antifungal drugs, such as: ketoconazole and fluconazole. Antifungals may slow down the metabolism of Hysone 4 and lead to an increase in blood levels, thus leading to increased risk of side effects.
  • Anticoagulant drugs, such as: warfarin and acenocoumarol. Concomitant use may lead to increased risk of bleeding.
  • Aspirin (acetylsalicylic acid).

Inform your doctor about all medicines you are taking or you have recently taken.

Adverse Effects

Hysone 4 may cause following side effects:

  • Convulsions.
  • Increased intracranial pressure.
  • Esophagitis.
  • Psychiatric disorders.
  • Hyperglycemia.
  • Hypokalemia.
  • Congestive heart failure.
  • Dyspepsia.
  • Cataracts.
  • Increased intraocular pressure.
  • Myocardial rupture in patients who suffered heart attack.
  • Leukocytosis.
  • Weight gain.
  • Hypertension.
  • Osteoporosis.
  • Pancreatitis.
  • Headache.
  • Dizziness.
  • Menstrual disorders.
  • Glaucoma.

You must inform your doctor at once should you notice any side effect.

References

  1. FDA

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If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.