Imdur 30 mg

Imdur 30 mg - Use | Dose | Effects

Imdur 30 mg is a drug that belongs to a group of organic nitrates and works by expanding the blood vessels and increasing blood flow to the heart. It is used for the prevention of attacks of angina pectoris and for the treatment of congestive heart failure. Angina pectoris occurs because the heart does not receive enough blood and nutrients carried by the blood. Angina pectoris causes a sense of tightness and pain in the chest. Congestive heart failure occurs because the heart is not strong enough to pump the blood throughout the body which causes a breathing problems.

Precautions

Imdur 30 mg is contraindicated in the following conditions:

  • In patients who have anemia
  • In patients with recent heart attack
  • In patients with cerebral hemorrhage
  • In patients with head trauma
  • In patients with hypotension
  • In patients with cardiogenic shock
  • In patients who are taking medicines used for to treat erectile dysfunction (e.g. Viagra)
  • In patients with hypertrophic obstructive cardiomyopathy
  • In patients with high eye pressure
  • In patients who have a deficiency of glucose-6-phosphate dehydrogenase. Studies have shown that this drug can cause hemolysis in these patients.1

Precautions are also necessary in the following conditions:

  • Malnutrition
  • Hypothyroidism
  • Hepatic insufficiency
  • Renal insufficiency
  • Intestinal hypomotility
  • Hypothermia
  • Impaired circulation

Use of Imdur 30 mg during pregnancy and breastfeeding

There is not much data available on the use of this drug during pregnancy. Animal studies have shown that this drug exhibits some toxicity to the fetus. You should not use this medicine during pregnancy if you didn't consult your gynecologist previously. This drug has been proven to be very effective for cervical ripening after termination of pregnancy in the first or second trimester.2,3

Avoid breastfeeding while you are taking Imdur 30 mg tablets.

How to use

The usual dosage is two tablets once a day or one tablet twice a day. It is very important that there is a certain interval between the two doses (i.e. nitrate-free period) because otherwise nitrate tolerance may occur (this means that this drug will be less effective after repeated dosing). Tolerance is not created if this drug is taken once or twice daily.4

Take your pills after a meal (in the morning after breakfast and in the evening after dinner). Studies have shown that food does not affect the bioavailability of this medication.5

The maximum daily dose is 120 mg.

Interactions

Imdur 30 mg may enter into a major interactions with the following medications:

  • Inhibitors of phosphodiesterase 5 (PDE-5), such as:
    • sildenafil (Viagra)
    • tadalafil
    • vardenafil
  • Riociguat - a drug used in the treatment of pulmonary hypertension
  • Tizanidine - muscle relaxant
  • Epinephrine (adrenaline)

Side effects

Imdur 30 mg may cause the following side effects:

  • Headache (occurs very often)
  • Drowsiness
  • Tachycardia
  • Orthostatic hypotension (a sudden drop in blood pressure when getting up from a lying position)
  • Collapse
  • Excessive sweating
  • Exfoliative dermatitis
  • Swelling of the skin

References