Jardiance - How to use | Interactions | Effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Jardiance is a medicine containing active ingredient called empagliflozin and belongs to a family of drugs called SGLT2 inhibitors. SGLT2 is a protein that inhibits the excretion of glucose in the urine, and its blockage leads to increased glucose excretion through urine that directly reduces blood glucose levels.

It is used to treat type 2 diabetes mellitus in adult patients (older than 18 years).

It is mostly used in patients in whom diet, physical activity or monotherapy with metformin has not yielded satisfactory results.

It can be used as a monotherapy or in combination with metformin (combination with metformin is known as Jardiamet).


Jardiance is contraindicated in patients:

  • Who have severe kidney damage
  • Who have end-stage of kidney disease (final stage of kidney disease, in which the kidney function is not sufficient to meet the needs of the body)
  • Who are on dialysis.

The efficacy of Jardiance depends on the kidney function, therefore its use in patients with impaired kidney function must be avoided.

Patients with known allergy to the active substance - empagliflozin, should not be prescribed this medication.

Its use in patients above the age of 85 is also contraindicated.

Since this medication has not been studied in patients under the age of 18, its use in this age group must be avoided.


It should be carefully applied in patients over 75 years of age, as these patients often have impaired renal function. Appropriate comprehensive evaluation of kidney function should be done prior initiating therapy.

Caution is required in patients receiving water pills, and in patients who have low blood pressure.

Jardiance and its use during pregnancy and breastfeeding

For now, there are not enough data on the use of this medicine during pregnancy to conclude that Jardiance is safe during pregnancy, and therefore it should not be used in pregnant women.

You should discontinue breastfeeding while using this medicine, because safety of Jardiance in infants has not been established.

How to use

You can take the pill regardless of food at any time of the day. However, it is recommended that you take the pill every day at the same time.

The recommended dose is 10 mg once daily. The dose may be increased to 25 mg daily if your doctor considers it necessary.

Swallow the pill whole with a glass of water. Do not break, crush or chew the film-coated tablets because it can change their efficacy.

Diet and proper lifestyle changes are still necessary, despite taking Jardiance pills, because adequate lifestyle changes may help you achieve better glycemic control.


Jardiance must be carefully administered concomitantly with insulin, as hypoglycemia may occur. It is necessary to adjust the insulin dose if you're taking these two drugs concurrently.

It should not be used concomitantly with gatifloxacin, because concomitant administration increases the risk of low blood sugar.

Side effects

Side effects of Jardiance include:

  • Presence of blood in urine
  • Frequent urination
  • Difficulty urination
  • Infections of the urinary tract
  • Headache
  • Blurred vision
  • Tachycardia
  • Low blood pressure
  • Confusion
  • Seizures
  • Fatigue
  • Loss of appetite
  • Difficulty breathing
  • Dry mouth
  • Weight loss
  • Loss of voice
  • Fungal infections
  • Increased blood levels of LDL cholesterol
  • Hypoglycemia
  • Balanoposthitis
  • Inflammation of the joints


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