Lyrica

Lyrica - Dosage | Side Effects | Use

Category Antiepileptics

Lyrica (Pregabalin) is a medicine from the group of medicines called antiepileptics or anticonvulsants.

Indications

Neuropathic pain

Lyrica is indicated for the treatment of central and peripheral neuropathic pain in adults.

Epilepsy

Lyrica is indicated as adjunctive therapy in adults with partial seizures, with or without secondary generalization.

Generalized anxiety disorder

Lyrica is indicated for the treatment of generalized anxiety disorder (GAD) in adults.

Dosage and administration

The dose is in the range of 150 to 600 mg daily, divided into two or three doses.

Neuropathic pain

Treatment with Lyrica may commence with a dose of 150 mg daily, divided into two or three doses. Depending on the response and tolerability of the medicine in the individual patient, the dose after a period of 3 to 7 days can be increased to 300 mg daily and, if necessary, after an additional 7 days to a maximum dose of 600 mg per day.

Epilepsy

Treatment with Lyrica may commence with a dose of 150 mg daily, divided into two or three doses. Depending on the response and tolerability of the medicine in the individual patient, the dose may be after one week increased to 300 mg per day. The maximum dose of 600 mg per day may be achieved after an additional week.

Generalized anxiety disorder

The dose is in the range of 150 to 600 mg daily, divided into two or three doses. It should be regularly evaluate the need for treatment. Treatment with Lyrica may commence with a dose of 150 mg per day. Depending on the response and tolerance of the medicine in the individual patient, the dose may be after one week increased to 300 mg per day. After the following week the dosage may be increased to 450 mg per day. The maximum dose of 600 mg per day can be achieved after an additional one week.

Discontinuation treatment with Lyrica

In accordance with current clinical practice, if Lyrica treatment must be discontinued, it is recommended to gradually phased out for at least one week, regardless of the indication.

Special populations (Patients with renal impairment)

Lyrica is removes from the systemic circulation primarily with excretion of unchanged medicine via kidney. Since the clearance of Lyrica is exactly proportional to the clearance of creatinine, in an individual patient with renal impairment the dose must be adjusted in accordance with the a creatinine clearance (CLcr), as indicated in table 1, using the following formula: CLcr(ml/min)=] x 0,85 Lyrica is effectively removed from the plasma by hemodialysis  50 % of the medicine over 4 hours). In the patients undergoing hemodialysis, the daily dose of Lyrica should be adjusted based on renal function. In addition to daily dose should be administered an additional dose of Lyrica immediately after each four-hour procedure hemodialysis treatment (see Table 1).

Clearance creatinine (CLcr) (ml / min) The total daily dose of Lyrica Frequency of dosing
Initial dose The maximum dose
60 150 600 Divided in 2 or 3 doses
>=30 60 75 300 Divided in 2 or 3 doses
>=15 30 25-50 150 Once a day or divided in 2 doses
15 25 75 Once a day
Supplemental doses after hemodialysis (mg)
25 100 One dose

Liver disorder

It is not necessary to adjust the dose in patients with hepatic impairment.

Pediatric population

The safety and efficacy of the medicine Lyrica in children younger than 12 years and adolescents (12-17 years) were no established. No information available.

Use in the elderly (over 65 years)

In older patients it may be necessary to reduce the dose of Lyrica for impaired renal function (see Patients with renal impairment).

Method of application

Lyrica can be taken with or without food. Lyrica is intended for oral administration.

Warning and precautions

Do not use Lyrica If you are allergic to Lyrica or any other medicine.

Patients with diabetes

In accordance with current clinical practice, some patients with diabetes who gain weight during treatment with Lyrica may be necessary to adjust the anti-diabetic therapy.

Hypersensitivity reactions

It have been reported hypersensitivity reactions, including cases of angioedema. Application of Lyrica should be stopped immediately in case of symptoms of angioedema, such as swelling of the face, the area around the mouth or upper respiratory tract.

Dizziness, somnolence, loss of consciousness, confusion and weakening of mental ability

Treatment of Lyrica is associated with the occurrence of somnolence, dizziness, which can increase the number of unintentional injuries (falls) in the elderly population. It have been reported and loss of consciousness, confusion and weakening of mental ability. Therefore, patients should be advised to be careful until they are familiar with the potential effects of the medicine.

Effects associated with vision

In controlled clinical trials, blurred vision was reported in a higher proportion of patients treated with Lyrica than patients receiving the placebo. These side effects in most cases was withdrawn from continued therapy. In clinical trials in which was conducted ophthalmic search, reduction of visual acuity and visual field changes, there was a higher incidence in patients who used Lyrica than in the placebo group; the incidence of changes in the eye fundus was higher in patients who received placebo. Side effects associated with vision have been reported in the aftermath of marketing experience, including loss of vision, blurred vision or other changes in visual acuity, and many of which were transient. Termination of application of Lyrica may result in withdrawal symptoms, or improvements of that symptoms.

Overdose

In overdoses up to 15 g there are not reported unexpected adverse effects. After placing the Lyrica on the market most commonly reported side effects of an overdose of Lyrica include somnolence, confusion, agitation and restlessness. Treatment of Lyrica overdose should include general supportive measures, if necessary, may include hemodialysis. You should never take more tablets than you prescribed by your doctor. If  you have taken too many tablets at once, contact your doctor immediately. Show the doctor the remaining tablets in the package.

If you forget to take the medicine

If you forget to take medication, do not use double dose later. Simply continue to use the medicine according to the usual schedule. If you missed medication applied, please do so as soon as possible, and then proceed with its application to the usual schedule and suitably.