Lyso-6 - Use | Dose | Side Effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Lyso-6 is a medicine that contains two active substances: lysozyme and pyridoxine (vitamin B6). It belongs to the group of local antiseptics intended for use on the mucous membranes of the throat and pharynx. Lysozyme exerts an anti-inflammatory activity and acts against Gram-positive and Gram-negative bacteria. Pyridoxine exerts a protective effect on the mucous membranes of the throat. In studies, pyridoxine was proved to be an excellent agent for the treatment of aphthae (small ulcers/blisters in the mouth).

Lyso-6 is used to treat aphthae and other non-infectious diseases of the mouth or throat mucosa.


Lyso-6 is contraindicated in the following conditions:

  • In children younger than 7 years
  • In patients who are allergic to lysozyme or pyridoxine

Lyso-6 should not be used in cases where a bacterial infection is presented. If you are experiencing symptoms of a bacterial infection (e.g. sore throat, fever and cough), then you must not use this medication.

Lyso-6 should not be used longer than 5 days because prolonged use leads to an imbalance in the normal bacterial flora in the mouth.

Use of high doses of pyridoxine over long period of time, can cause numbness in hands and feet, tremor and difficulty in coordinating movements. These are signs of sensory neuropathy which usually disappears quickly after discontinuation of treatment.

This drug does not affect consciousness and you can operate vehicles and machines without taking any special precautions.

Lyso-6, pregnancy and breastfeeding

Pyridoxine is actually a vitamin B6, and as such, it is a part of numerous vitamin supplements intended for use during pregnancy. Pyridoxine is safe for application during pregnancy, but for second ingredient of this medicine - lysozyme, there are not enough data from relevant clinical studies to confirm its safety during pregnancy. For this reason, Lyso-6 is not recommended for use during pregnancy.

Avoid the use of this drug during breastfeeding because it is not known what effect will lysosome exert on infants.


The usual dose is 6-8 compressed lozenges (tablets) per day. Take one lozenge, place it under your tongue and let it slowly dissolve. You can take another lozenge after one hour. Do not exceed maximum daily dose (don't take more than 8 lozenges daily).

Food does not affect the effectiveness of Lyso-6.


To date, there are no reported cases of an overdose with this drug and symptoms of an overdose are not expected to be serious. However, use of high doses increases your risk of neuropathy.


The only known interaction of Lyso-6 with other drugs is the one with levodopa (a drug used to treat Parkinson's disease). Lyso-6 contains pyridoxine, which reduces the effectiveness of this drug.

Adverse reactions

The most commonly reported adverse reactions in clinical studies are:

  • Quincke's edema (swelling of the facial skin due to the allergic reactions)
  • Urticaria (hives)
  • Photosensitivity
  • Itchy skin

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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