Maxipime - Use | Dosage | Side Effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on Thu, 27 Dec 2018. To read more about an author, click here.

Maxipime contains cefepime as an active substance and belongs to the fourth generation of cephalosporins. Maxipime is a broad spectrum antibiotic and exerts bactericidal effects by inhibiting bacterial cell wall synthesis. It is effective against both, gram positive and gram negative bacteria. Most of the strains of bacteria that are resistant to the second and third generation of cephalosporins are susceptible to Maxipime. It has bactericidal effect on the following gram-negative bacteria:

  • Pseudomonas aeruginosa
  • Escherichia coli
  • Proteus mirabilis
  • Klebsiella pneumoniae

It also has bactericidal effect on following gram-positive bacteria:

  • Staphylococcus aureus
  • MRSA
  • Streptococcus pneumonia
  • Streptococcus pyogenes
  • Staphylococcus agalactiae
  • Staphylococcus saprophyticus
  • Staphylococcus epidermidis

As you can see, the list of bacteria that are sensitive to Maxipime is quite long, and because of that Maxipime can be used to treat a number of infections, including:

  • Uncomplicated skin infections
  • Soft tissue infections
  • Uncomplicated and complicated urinary tract infections
  • Infections of the lower respiratory tract
  • Febrile neutropenia
  • Complicated intra-abdominal infections

Contraindications and precautions

Maxipime is contraindicated in patients who are hypersensitive to this drug or other cephalosporin or penicillin antibiotics.

Precautions must be taken in the following situations:

  • In patients with renal impairment (in patients who have creatinine clearance less than 60 ml / min dose of this drug must be reduced).
  • In patients with liver damage.
  • In patients who have gastrointestinal bleeding.
  • In patients who have a history of colitis.

Although very rarely, Maxipime can cause encephalopathy which may be life threatening. If you notice symptoms, such as: hallucinations, confusion, excessive sleepiness, you should go to your physician immediately.

Maxipime, pregnancy and breastfeeding

Maxipime belongs to the group B because there are no adequate clinical studies of the use of this drug in pregnant women. Results of animal studies have shown no teratogenic properties of this drug. It can be used during pregnancy only if your doctor thinks that the benefits outweigh the risks.

Maxipime is excreted into the breast milk and breastfeeding should be avoided while you're on the treatment with this drug.


Maxipime exists only in the form of injections and IV infusions and may be administered only intramuscularly or intravenously. There are no oral forms of this drug. Therefore, Maxipime is administered only in health facilities by trained healthcare staff.

The usual dosage is 1-2 grams of Maxipime applied two or three times daily. The dosage depends on the severity of the infection.

It can be used in babies older than 2 months.

Typically, the duration of treatment is 7-10 days but it can be longer if the infection becomes more severe.


Maxipime should not be administered concomitantly with other medications that may cause damage to the kidney, such as:

  • Aminoglycoside antibiotics, such as: gentamicin, amikacin and streptomycin.
  • Diuretics, such as: furosemide

Side effects

Maxipime may cause the following side effects:

  • Increase in blood alkaline phosphatase
  • Decrease in blood calcium level
  • Increase in blood creatinine (this indicate renal impairment)
  • Increase in blood phosphorus level
  • Phlebitis
  • Headache
  • Oral moniliasis
  • Vaginitis
  • Inflammation at the site of application
  • Increase in blood ALT levels
  • Eosinophilia
  • Allergy
  • Diarrhea

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.