Mogadon

Mogadon - Dosage instructions | Effects

Mogadon as an active substance contains nitrazepam and belongs to the group of benzodiazepines. It acts as sedative, shortens sleep onset and extends total sleep time. It is used for short-term treatment of insomnia.

In one study which compared this drug with lorazepam (also a benzodiazepine) and placebo, it was found that Mogadon extends sleep time, but it increases incidence of clumsiness and confusion, compared to placebo and lorazepam.

Precautions

Mogadon is contraindicated in the following conditions:

  • If you have myasthenia gravis (an autoimmune disease characterized by the production of antibodies which destroy the muscles and that causes symptoms such as fatigue of skeletal muscles and malaise). Mogadon belongs to the group of benzodiazepines, so it exerts muscle relaxing effect, which further exacerbate the symptoms of myasthenia gravis.
  • If you have severe liver impairment
  • If you have pulmonary diseases. There have been reports of respiratory depression induced by this drug.
  • If you suffer from panic-manic disorders

As Mogadon use may produce dependence, extra precaution is recommended for patients who have a history of substance abuse.

Keep in mind that if you're applying this medicine for long periods of time that its effects may gradually weaken over time, so you'll need to take higher doses to achieve the same effects as at the beginning of therapy. Never increase your dose without consulting your doctor. Do not take this drug more than two weeks. Your doctor will probably recommend you to take the lowest effective dose in order to reduce the risk of dependence.

Mogadon can cause retrograde amnesia which is a characteristic side effect of benzodiazepines. Retrograde amnesia is memory loss while under the influence of this drug.

Mogadon, pregnancy and lactation

Newborns whose mothers took this drug during the last three months of pregnancy may have the following symptoms:

  • Abnormal muscle relaxation
  • Hypothermia - low body temperature
  • Respiratory depression (shortness of breath)
  • Dysphagia (difficulty swallowing)

For this reason, Mogadon should not be used during pregnancy.

Mogadon occurs in breast milk in small concentrations so breastfeeding should be avoided.

Dosage instructions

The usual dose is 5 mg taken forty minutes before bedtime. Therapy should not last longer than two weeks.

Taking this medication longer than two weeks, increases your chances of becoming addicted.

Take the tablet with 1 cup of water regardless of meals.

Withdrawal symptoms (severe headache, restlessness, irritability, muscle pain, hallucinations or convulsions) can occur if you suddenly stop taking Mogadon. It is therefore recommended to reduce the dosage gradually before complete cessation of the drug. So, for example, if you're taking 5 mg daily, your doctor will recommend that you reduce your dose to 2.5 mg daily and to take it for next three or four days, and after that you can stop this drug completely.

It is recommended to use lower dose (2.5 mg per day) in patients older above the age of 67.

Interactions

Mogadon can interact with the following medicines so the concomitant use with these medicines should be avoided:

  • Atypical antipsychotics used for the treatment of bipolar depression, acute mania and schizophrenia, such as:
  • Phenothiazine antipsychotics, such as:
    • chlorpromazine
    • acetophenazine
    • fluphenazine
    • thioridazine
    • trifluoroperazine
  • Butyrophenone antipsychotics, such as:
    • haloperidol
    • droperidol
  • Thioxantene antipsychotics, such as:
    • thioxanthene
    • meprotiksol
    • pimetiksen
    • chlorprothixene
  • General and local anesthetics.
  • Opioid analgesics
  • Drugs used for the treatment of epilepsy, such as:
  • Dimenhydrinate and chloropyramine (antihistamines)
  • Antidepressants
  • Anxiolytics

Never apply this medicine simultaneously with alcoholic beverages because concomitant use increases the risk of coma.

Adverse effects

Mogadon may cause the following adverse effects:

  • Emotional disorders
  • Muscle weakness
  • Headache
  • Dizziness
  • Decreased libido
  • Reduction of attention
  • Retrograde amnesia
  • Anxiety
  • Irritability
  • Drowsiness
  • Hallucinations
  • Delusions
  • Aggressiveness
  • Nightmares
  • Stomach upset