Nexium - Use | Interactions | Side Effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Nexium is a medicine from the group of proton pump inhibitors (PPIs). Nexium acts by blocking the proton pump in gastric cells and thereby reduces the acid secretion in the stomach.

Nexium is used in the treatment of the following conditions:

  • Gastroesophageal reflux disease (GERD)
  • Stomach or duodenal ulcers
  • Heartburn

In addition to the use of Nexium, you should avoid spicy and fatty foods, smoking, stress, alcoholic beverages. You should eat small meals throughout the day and use milk products.


Nexium should not be used if you are allergic to nexium or other similar medicines such as: pantoprazole, omeprazole.

Nexium tablets are contraindicated if:

  • You have liver or kidney disorders
  • You have low magnesium levels in the blood (hypomagnesaemia)
  • You have osteoporosis (bone disease). Prolonged use of Nexium tablets, may lead to bone fracture (broken bone).

Use of Nexium during pregnancy and breastfeeding

Nexium can be used during pregnancy only if the benefit to the mother outweighs the risk to the child.

It is now known whether Nexium passes into breast milk. Avoid breast-eeding while on Nexium treatment.

How to use

Nexium can be used at any time of the day, although it is recommended to use Nexium at the morning, after getting up, with a glass of lukewarm water. Do not eat at least one hour after taking Nexium, before food may change the effect of Nexium.

Do not break the tablet, swallow it whole.

Long-term use of Nexium can lead to bone damage and a lack of vitamin B12 (anemia).

Nexium can be used only for patients older than 12 years.

The usual daily dose of Nexium is 20 mg. The dose may be increased according to the severity of the condition. Nexium is usually used during one month, but it can be used for longer if necessary.

Use with other medicines (Interactions)

Nexium should not be used in combination with the following medicines:

  • Digoxin, used to treat heart failure
  • Warfarin (Farin), acenocoumarol (Sinter, Sinkum 4), used to treat thrombosis.
  • Medicines used for the treatment of AIDS, such as HIV-protease inhibitors.
  • Medicines used for the treatment of fungal infections such as azole anti-fungal agents.
  • Antibiotics
  • Cisapride, used for the treatment of digestive disorders.
  • Phenytoin, used to treat epilepsy.
  • Diazepam (Bensedin), used for the treatment of insomnia.
  • Antidepressants (tricyclic antidepressants and selective serotonin reuptake inhibitors).
  • St. John's Wort.
  • Tacrolimus, used to prevent rejection of transplanted organs.
  • Clopidogrel, used for platelet aggregation inhibition, usually after a heart attack.

Tell your doctor about all medications and herbal medicines you are taking.

Side effects

Nexium may cause the following side effects:

  1. nausea,
  2. vomiting,
  3. bloating,
  4. abdominal pain,
  5. diarrhea (which can be accompanied by blood),
  6. headache,
  7. dizziness,
  8. mood changes (depression),
  9. hallucinations,
  10. alopecia (hair loss),
  11. taste changes,
  12. kidney damage manifested by difficult urinating and blood in the urine (dark urine),
  13. increased liver enzyme levels in the blood,
  14. liver damage,
  15. which is accompanied by jaundice,
  16. gynecomastia (breast enlargement),
  17. low leukocytes count in the blood (agranulocytosis),
  18. allergy and other.

Tell your doctor if you get any of side effects.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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